Results 131 to 140 of about 73,139 (321)

Development of a multiplexed targeted mass spectrometry assay for LRRK2-phosphorylated Rabs and Ser910/Ser935 biomarker sites [PDF]

, 2020
Raja Sekhar Nirujogi, Francesca Tonelli, Matthew Taylor, Paweł Lis, Alexander Zimprich, Esther Sammler, Dario R. Alessi   +6 more
openalex   +1 more source

Proteomic and Lipidomic Profiling of Immune Cell‐Derived Subpopulations of Extracellular Vesicles

PROTEOMICS, EarlyView.
ABSTRACT Extracellular vesicles (EVs) are heterogeneous and play important roles in intercellular communication, contributing to physiological and pathological processes. Since few markers currently exist to differentiate subtypes of EVs, this study aimed to determine proteomic and lipidomic differences among four EV subpopulations. Large and small EVs
Anna Lischnig, Nasibeh Karimi, Per Larsson, Karin Ekström, Rossella Crescitelli, Anna‐Carin Olin, Cecilia Lässer   +6 more
wiley   +1 more source

An RNA interference biopesticide reduces reproduction of the honey bee parasite Varroa destructor by down‐regulating embryo development pathways

Pest Management Science, EarlyView.
Varroa destructor mites exposed to dsRNA specific in sequence to a V. destructor calmodulin gene significantly effected gene expression of adult female mites sampled 5 days after entering a honey bee brood cell to reproduce. Significantly down‐regulated genes included Calmodulin and were associated with calcium ion binding and embryo developmental ...
Zoe E Smeele, Rose A McGruddy, James W Baty, Brian Manley, Kenneth Narva, Emma De Neef, Eric RL Gordon, Upendra K Devisetty, Katie Youngs, Antoine Felden, Philip J Lester   +10 more
wiley   +1 more source

Ablating the Rab‐GTPase activating protein TBC1D1 predisposes rats to high‐fat diet‐induced cardiomyopathy [PDF]

, 2019
Pierre‐Andre Barbeau, Jacy M. Houad, Jason S. Huber, Sabina Paglialunga, Laelie A. Snook, Eric A.F. Herbst, Kaitlyn M.J.H. Dennis, Jeremy A. Simpson, Graham P. Holloway   +8 more
openalex   +1 more source

Uncovering Exotic Topological Quantum States in Pure and Magnetically‐Doped Pyrite OsS2

Advanced Quantum Technologies, EarlyView.
Pyrite‐structured OsS2 is identified as a fragile topological insulator with an unprecedented 602 meV bandgap, featuring helical surface states and van Hove singularities amenable to ARPES verification. Magnetic doping with Pd, Fe, Ni, or Co induces phase transitions to strong topological insulators, semimetals, 3D quantum anomalous Hall insulators ...
Ali Sufyan, Hasan M. Abdullah, Gustav Johansson, Alexander C. Tyner, Hafiz Adil Qayyum, Ghulam Abbas Gilani, Rovi Angelo B. Villaos, Zhi‐Quan Huang, Feng‐Chuan Chuang, J. Andreas Larsson   +9 more
wiley   +1 more source

Stabilized Extracellular Vesicle Formulations for Inhalable Dry Powder Development

Small, EarlyView.
Extracellular vesicles (EVs) hold promise for chronic obstructive pulmonary disease (COPD) treatment but face challenges with storage and delivery. This study demonstrates the stabilization of lung fibroblast‐derived EVs using inulin, enabling freeze‐drying and spray‐drying.
Eva M. Jansen, Luke van der Koog, Robin A.B. Elferink, Karim Rafie, Anika Nagelkerke, Reinoud Gosens, Henderik W. Frijlink, Wouter L.J. Hinrichs   +7 more
wiley   +1 more source

Advances in reactive air wetting and brazing of engineering ceramics

Journal of Advanced Ceramics
The reactive air brazing (RAB) process of ceramics was developed in the early 2000s because high-temperature electrochemical devices, such as solid oxide fuel cells (SOFCs), gas separators, reformers, and ion transport membrane systems, are increasingly ...
Mingfen Zhang, Shunjian Xu, Fabrizio Valenza, Xiangzhao Zhang, Guiwu Liu, Guanjun Qiao   +5 more
doaj   +1 more source

From Membrane Composition to Antimicrobial Strategies: Experimental and Computational Approaches to AMP Design and Selectivity

Small, EarlyView.
Antimicrobial peptides (AMPs) are promising candidates for next‐generation antibiotics, acting through mechanisms such as membrane disruption and intracellular targeting. This review examines how variations in bacterial membrane composition critically influence AMP activity.
Paolo Rossetti, Marius F.W. Trollmann, Christina Wichmann, Thomas Gutsmann, Christian Eggeling, Rainer A. Böckmann   +5 more
wiley   +1 more source

Organelle Sorting and Proteomic Analysis to Identify Proteins Involved in the Uptake and Intracellular Trafficking of Nanoparticles

Small Methods, EarlyView.
A new method to identify proteins involved in the uptake and intracellular trafficking of nanoparticles is presented. After nanoparticle uptake, cells are lysed and the organelles with nanoparticles are purified using fluorescence assisted cell sorting. Next, their composition is determined by proteomic analysis.
Hector Garcia Romeu, Anna Salvati
wiley   +1 more source

rs6971 TSPO polymorphism in Parkinson's disease

Movement Disorders, EarlyView.
Bina Patel, Marta Camacho, Jonathan R. Evans, David P. Breen, Thomas Foltynie, Sarah L. Mason, Gemma Cummins, Ruwani Wijeyekoon, Roger A. Barker, Caroline Helen Williams‐Gray   +9 more
wiley   +1 more source