Results 141 to 150 of about 244,605 (365)
Exosomes, autophagy, and cancer: A complex triad
International Journal of Cancer, EarlyView.Abstract Cancer remains one of the leading causes of death worldwide. Despite remarkable progress in prevention, diagnosis, and therapy, the incidence of certain types of cancer persists, urging the identification of clinically relevant biomarkers and the development of novel therapeutic strategies to improve clinical outcomes and overcome treatment ...
María Guerra‐Andrés +2 more
wiley +1 more source
Biochemical Journal, 2017 Mutations that activate the LRRK2 (leucine-rich repeat protein kinase 2) protein kinase predispose to Parkinson's disease, suggesting that LRRK2 inhibitors might have therapeutic benefit.
P. Lis +14 more
semanticscholar +1 more source
iMetaOmics, EarlyView.This study has elucidated the role of three swine acute diarrhea syndrome coronavirus (SADS‐CoV) accessory proteins in influencing viral pathogenicity and preliminarily explored the host molecular targets and pathways affected by the NS3a, NS7a, and NS7b proteins of SADS‐CoV.
Xiaoling Yan +7 more
wiley +1 more source
Climate change and commercial fishing practices codetermine survival of a long‐lived seabird
Global Change Biology, Volume 29, Issue 2, Page 324-340, January 2023., 2023 Commercial fishing intensity (a) was directly (via entanglement risk associated with long‐line fishing) and indirectly (via reductions in Atlantic menhaden production associated with commercial trawling) link to increased risk of Royal tern mortality. Although (b) sub‐adult (ages 3–4) and adult (age >5) survival has increased over time partially as a ...
Daniel Gibson +7 more
wiley +1 more source
Rab GTPases as Physiological Substrates of LRRK2 Kinase
Experimental Neurobiology, 2019 LRRK2 (Leucine-Rich Repeat Kinase 2) is a gene whose specific mutations cause Parkinson's disease (PD), the most common neurodegenerative movement disorder. LRRK2 harbors GTPase and kinase activities, two enzyme activities that play critical roles in the
W. Seol, Daleum Nam, I. Son
semanticscholar +1 more source
RAB21 Activity Assay Using GST-fused APPL1
Bio-Protocol, 2016 The Rab family of small GTPases are essential regulators of membrane trafficking events. As with other small GTPase families, Rab GTPases cycle between an inactive GDP- bound state and an active GTP-bound state. Guanine nucleotide exchange factors (GEFs)
Steve Jean, Amy Kiger
doaj +1 more source
Organoid‐tissue extracellular vesicles
Interdisciplinary Medicine, EarlyView.Abstract Extracellular vesicles (EVs) are lipid bilayer structures secreted by cells that act as intercellular messengers. Tissue‐derived EVs (TEVs), harvested from the tissue interstitium, directly reflect the actual physiological or pathological state of the tissue microenvironment.
Han Liu +6 more
wiley +1 more source
Electromagnetic source localization with finite set of frequency measurements [PDF]
, 2014 A phase conjugation algorithm for localizing an extended radiating electromagnetic source from boundary measurements of the electric field is presented. Measurements are taken over a finite number of frequencies.
Anjum, Saman +3 more
core
Treatment Selection and Prioritization for the EJS ACT‐PD MAMS Trial Platform
Movement Disorders, EarlyView.Abstract Background There are currently no disease‐modifying therapies (DMTs) registered for Parkinson's disease (PD). The Edmond J. Safra Accelerating Clinical Trials in Parkinson Disease (EJS ACT‐PD) initiative will expedite clinical assessment of putative DMTs through a multi‐arm multistage (MAMS) trial, testing several treatments against a common ...
Cristina Gonzalez‐Robles +29 more
wiley +1 more source
Cell Reports, 2020 Summary: To explore the mechanism of Rab5/RAB-5 activation during endocytic recycling, we perform a genome-wide RNAi screen and identify a recycling regulator, LET-502/ROCK.
Wenjuan Zhang +14 more
doaj