Results 161 to 170 of about 54,351 (195)
RME-1-associated recycling endosomes participate in vitellogenin secretion in <i>Caenorhabditis elegans</i>. [PDF]
Life MetabZhai C, Dong MQ.
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2000
Abstract A hallmark of eukaryotic cells is their possession of a set of membrane-enclosed organelles. The traffic of proteins between different organelles of the secretory and endocytic pathways is mediated by membrane-bound containers, termed vesicles. Figure 1 illustrates the basic stages of transport. Vesicles form by budding off from
Ruth N Collins, Patrick Brennwald
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Abstract A hallmark of eukaryotic cells is their possession of a set of membrane-enclosed organelles. The traffic of proteins between different organelles of the secretory and endocytic pathways is mediated by membrane-bound containers, termed vesicles. Figure 1 illustrates the basic stages of transport. Vesicles form by budding off from
Ruth N Collins, Patrick Brennwald
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Biochemical Society Transactions, 2018
Leucine-rich repeat kinase 2 (LRRK2) is mutated in familial Parkinson's disease, and pathogenic mutations activate the kinase activity. A tour de force screen by Mann and Alessi and co-workers identified a subset of Rab GTPases as bona fide LRRK2 substrates.
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Leucine-rich repeat kinase 2 (LRRK2) is mutated in familial Parkinson's disease, and pathogenic mutations activate the kinase activity. A tour de force screen by Mann and Alessi and co-workers identified a subset of Rab GTPases as bona fide LRRK2 substrates.
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Functional Properties of the Rab‐Binding Domain of Rab Coupling Protein
2005Rab-Coupling Protein (RCP) is an approximately 80-kDa, hydrophilic protein that belongs to a recently identified family of proteins that is characterized by its ability to interact with Rab11 via a highly homologous Rab-binding domain positioned at its carboxy-termini.
Lindsay, Andrew +2 more
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2014
Effector proteins interact with GTPases in their active/GTP-bound state. To achieve this specificity, all effector proteins interact with Rab proteins via a similar Rab surface area which shows the largest conformational changes upon nucleotide exchange. This surface is also involved in the interaction with other Rab interacting proteins.
Oesterlin, Lena Katharina +2 more
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Effector proteins interact with GTPases in their active/GTP-bound state. To achieve this specificity, all effector proteins interact with Rab proteins via a similar Rab surface area which shows the largest conformational changes upon nucleotide exchange. This surface is also involved in the interaction with other Rab interacting proteins.
Oesterlin, Lena Katharina +2 more
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1995
Abstract A full-length mouse GDI2 cDNA was isolated by screening a mouse skeletal muscle cDNA library with the full-length rat brain GDI1 cDNA (Shisheva et al. 1994). A cDNA clone found to be the mouse homolog of the previously reported bovine brain smg p25A-GDI (Matsui et al. 1990) and rat brain GDI1 (Shisheva etal.
Assia Shisheva, Michael P Czech
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Abstract A full-length mouse GDI2 cDNA was isolated by screening a mouse skeletal muscle cDNA library with the full-length rat brain GDI1 cDNA (Shisheva et al. 1994). A cDNA clone found to be the mouse homolog of the previously reported bovine brain smg p25A-GDI (Matsui et al. 1990) and rat brain GDI1 (Shisheva etal.
Assia Shisheva, Michael P Czech
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Cycling of Rab Proteins: Role of Rab GDI in the Reversible Membrane Association of Rab GTP-Ases
1995Small GTPases of the Rab family are specific regulators of intracellular vesicular traffic. Mutational analysis of Rab proteins suggests that it is the membrane-bound and GTP-bound form of the molecule that is active in vesicle docking or fusion. Since Rab proteins are also present in a cytosolic pool in the cell, it has been postulated that they ...
Oliver Ullrich, Marino Zerial
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