Results 11 to 20 of about 244,605 (365)
Rab GTPases: Central Coordinators of Membrane Trafficking in Cancer
Frontiers in Cell and Developmental Biology, 2021 Tumor progression involves invasion, migration, metabolism, autophagy, exosome secretion, and drug resistance. Cargos transported by membrane vesicle trafficking underlie all of these processes.
Hongyuan Jin +13 more
doaj +2 more sources
Rab GTPases in Immunity and Inflammation [PDF]
Frontiers in Cellular and Infection Microbiology, 2017 Strict spatiotemporal control of trafficking events between organelles is critical for maintaining homeostasis and directing cellular responses. This regulation is particularly important in immune cells for mounting specialized immune defenses. By controlling the formation, transport and fusion of intracellular organelles, Rab GTPases serve as master ...
Akriti Prashar +3 more
openaire +5 more sources
PPM1H phosphatase counteracts LRRK2 signaling by selectively dephosphorylating Rab proteins
eLife, 2019 Mutations that activate LRRK2 protein kinase cause Parkinson’s disease. LRRK2 phosphorylates a subset of Rab GTPases within their Switch-II motif controlling interaction with effectors.
Kerryn Berndsen +11 more
doaj +2 more sources
Rab GTPases and their interacting protein partners: Structural insights into Rab functional diversity [PDF]
Small GTPases, 2017 Rab molecular switches are key players in defining membrane identity and regulating intracellular trafficking events in eukaryotic cells. In spite of their global structural similarity, Rab-family members acquired particular features that allow them to perform specific cellular functions. The overall fold and local sequence conservations enable them to
Pylypenko, Olena +3 more
openaire +4 more sources
Modification of the Adjustment Disorder New Module20 (ADNM-20) for Use in Military Environments (ADNM-20-MIL): A Delphi and Pilot Study. [PDF]
Int J Methods Psychiatr ResABSTRACT Objectives Despite its high prevalence and strong linkages with dangerous health outcomes, research on Adjustment Disorder (AjD) is hindered by lack of diagnostic clarity. AjD is categorized as a stress‐related disorder, highlighting the important role of the stressor(s) on AjD symptom onset and severity. The military community shows increased
Bajjani-Gebara J +4 more
europepmc +2 more sources
LRRK2 phosphorylation of Rab GTPases in Parkinson's disease
FEBS Letters, 2022 Rab GTPases comprise a large family of conserved GTPases that are critical regulators of the secretory and endocytic pathways. The human genome encodes ~ 65 Rabs that localize to discrete membrane compartments and, when in their GTP‐bound state, bind to ...
S. Pfeffer
semanticscholar +1 more source
Journal of Cell Biology, 2021 Borchers et al. review regulatory principles in the activation of endocytic Rab GTPases and how they apply to other Rab and Arf GTPases.
Ann-Christin Borchers +2 more
semanticscholar +1 more source
The Small GTPase Rab-35 Facilitates the Initiation of Phagosome Maturation and Acts as a Robustness Factor for Apoptotic Cell Clearance [PDF]
, 2021 We recently identified the novel function of the small GTPase RAB-35 in apoptotic cell clearance in Caenorhabditis elegans, a process in which dying cells are engulfed and degraded inside phagosomes.
Haley, Ryan, Zhou, Zheng
core +2 more sources
Current Opinion in Cell Biology, 2010 Rabs are GTP-binding proteins with conserved functions in membrane trafficking. They are regulated by a diverse group of structurally unrelated GDP-GTP exchange factors (GEFs), and a family of GTP-hydrolysis activating proteins (GAPs) containing the conserved TBC domain.
Barr, F, Lambright, D
openaire +3 more sources
Rab family of small GTPases: an updated view on their regulation and functions
The FEBS Journal, 2020 The Rab family of small GTPases regulates intracellular membrane trafficking by orchestrating the biogenesis, transport, tethering, and fusion of membrane‐bound organelles and vesicles.
Y. Homma, Shu Hiragi, M. Fukuda
semanticscholar +1 more source