Results 11 to 20 of about 73,139 (321)

LRRK2 phosphorylation of Rab GTPases in Parkinson's disease

FEBS Letters, 2022
Rab GTPases comprise a large family of conserved GTPases that are critical regulators of the secretory and endocytic pathways. The human genome encodes ~ 65 Rabs that localize to discrete membrane compartments and, when in their GTP‐bound state, bind to ...
S. Pfeffer
semanticscholar   +1 more source

Koja je formula kvalitetnoga odgoja?

Diacovensia, 2022
Što je dobar odgoj s obzirom na kvalitete koje iz njega trebaju proizići? Kako znamo da smo dobro odgojili dijete? I koje mu kvalitete trebamo usaditi?
Petra Domaćinović, Aleksandra Golubović   +1 more
doaj   +1 more source

Rab GTPases: Central Coordinators of Membrane Trafficking in Cancer

Frontiers in Cell and Developmental Biology, 2021
Tumor progression involves invasion, migration, metabolism, autophagy, exosome secretion, and drug resistance. Cargos transported by membrane vesicle trafficking underlie all of these processes.
Hongyuan Jin, Y. Tang, Liang Yang, Xueqiang Peng, Bowen Li, Qin Fan, Shibo Wei, Shuo Yang, Xinyu Li, Bo Wu, Mingyao Huang, Shilei Tang, Jingang Liu, Hangyu Li   +13 more
semanticscholar   +1 more source

Rab family of small GTPases: an updated view on their regulation and functions

The FEBS Journal, 2020
The Rab family of small GTPases regulates intracellular membrane trafficking by orchestrating the biogenesis, transport, tethering, and fusion of membrane‐bound organelles and vesicles.
Y. Homma, Shu Hiragi, M. Fukuda
semanticscholar   +1 more source

Therapeutic Targeting of Rab GTPases: Relevance for Alzheimer’s Disease

Biomedicines, 2022
Rab GTPases (Rabs) are small proteins that play crucial roles in vesicle transport and membrane trafficking. Owing to their widespread functions in several steps of vesicle trafficking, Rabs have been implicated in the pathogenesis of several disorders ...
Kate L Jordan, D. Koss, T. Outeiro, F. Giorgini   +3 more
semanticscholar   +1 more source

Who is important and who is not? On the reasons for including two distinguished renaissance Rab canons from the Stančić family into the integral alphabetical list of entries of the Croatian Biographical Dictionary

Studia Lexicographica, 2021
Using source materials, this paper attempts to explore the lives and work of two identically named protagonists of the social and cultural life of Rab in the second half of the 15th century.
Meri Kunčić
doaj   +1 more source

The Role of RAB GTPases and Its Potential in Predicting Immunotherapy Response and Prognosis in Colorectal Cancer

Frontiers in Genetics, 2022
Background: Colorectal cancer (CRC) is the third most common cancer worldwide, in which aberrant activation of the RAS signaling pathway appears frequently.
Xuefei Jiang, Lanlan Yang, Q. Gao, Yiting Liu, Xingzhi Feng, Shubiao Ye, Zihuan Yang   +6 more
semanticscholar   +1 more source

Warburg Micro syndrome is caused by RAB18 deficiency or dysregulation [PDF]

Open Biology, 2015
RAB18, RAB3GAP1, RAB3GAP2 and TBC1D20 are each mutated in Warburg Micro syndrome, a rare autosomal recessive multisystem disorder. RAB3GAP1 and RAB3GAP2 form a binary ‘RAB3GAP’ complex that functions as a guanine-nucleotide exchange factor (GEF) for ...
Mark T. Handley, Sarah M. Carpanini, Girish R. Mali, Duska J. Sidjanin, Irene A. Aligianis, Ian J. Jackson, David R. FitzPatrick   +6 more
doaj   +1 more source

Rabs on the fly: Functions of Rab GTPases during development [PDF]

Small GTPases, 2017
The organization of intracellular transport processes is adapted specifically to different cell types, developmental stages, and physiologic requirements. Some protein traffic routes are universal to all cells and constitutively active, while other routes are cell-type specific, transient, and induced under particular conditions only.
Sara Caviglia, David Flores-Benitez, Johanna Lattner, Stefan Luschnig, Marko Brankatschk   +4 more
openaire   +6 more sources

Rab proteins

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 1998
Rab proteins form the largest branch of the Ras superfamily of GTPases. They are localized to the cytoplasmic face of organelles and vesicles involved in the biosynthetic/secretory and endocytic pathways in eukaryotic cells. It is now well established that Rab proteins play an essential role in the processes that underlie the targeting and fusion of ...
Martinez, Olivier, Goud, Bruno
openaire   +2 more sources