Targeting Cancer With Bifunctional Peptides: Mechanism of Cell Entry and Inciting Cell Death
Cancer Science, EarlyView.()‐D‐Tox peptide binding to the ligands triggers their internalization via clathrin‐mediated endocytosis. Intracellular presence of ()‐D‐Tox peptide induces a transient loss of mitochondrial membrane integrity and oligomerization of MLKL. Translocation of the oligomers to the plasma membrane causes a leakage of the cytosolic content and ultimately ...
Maria F. Setiawan +2 more
wiley +1 more source
Role of the RAB27/SYTL Axis in Tumor Microenvironment Construction
Cancer Science, EarlyView.This review focuses on the role of the RAB27/SYTL axis in various cancer types associated with tumor microenvironment modifications. The importance of this pathway and the potential therapeutic strategies targeting vesicle production for the treatment of cancer are also discussed.
Miwa Tanaka, Takuro Nakamura
wiley +1 more source
Distinct Rab-binding domains mediate the interaction of Rabaptin-5 with GTP-bound rab4 and rab5 [PDF]
, 1998 Gaetano Vitale +6 more
openalex +1 more source
Res Medica, 2014 It is not unreasonable to see why medical textbooks come and go. The eternal truths found in anatomy can well be translated from edition to edition, hence the popularity and survival of Cunningham's and Jamieson's textbooks. It is not unexpected that the great textbooks of past such as Thomson and Myles Operative Surgery or Bennett’s Textbook of ...
openaire +2 more sources
Rab Conversion as a Mechanism of Progression from Early to Late Endosomes
Cell, 2005 J. Rink +3 more
semanticscholar +1 more source
Isoprenoid modification of rab proteins terminating in CC or CXC motifs.
, 1991 Roya Khosravi‐Far +8 more
openalex +1 more source
Identification of a GDI displacement factor that releases endosomal Rab GTPases from Rab-GDI [PDF]
, 1997 A. Barbara Dirac-Svejstrup
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Contact Dermatitis, EarlyView.ABSTRACT Neomycin, an aminoglycoside antibiotic frequently employed in topical formulations, is a recognised allergen that is part of many baseline series and can cause contact allergy (CA) in both adults and children. It is an allergen of interest as it has a widespread use in over‐the‐counter and prescription products globally, but geographical ...
Mikkel Bak Jensen +5 more
wiley +1 more source
Ras (CXXX) and Rab (CC/CXC) prenylation signal sequences are unique and functionally distinct.
, 1992 Roya Khosravi‐Far +7 more
openalex +1 more source
The Phosphatidylinositol 3-Phosphate Binding Protein Vac1p Interacts with a Rab GTPase and a Sec1p Homologue to Facilitate Vesicle-mediated Vacuolar Protein Sorting [PDF]
, 1999 Gregory G. Tall +3 more
openalex +1 more source