Results 31 to 40 of about 73,139 (321)
Defects in the COG complex and COG-related trafficking regulators affect neuronal Golgi function.
Frontiers in Neuroscience, 2015 The Conserved Oligomeric Golgi (COG) complex is an evolutionarily conserved hetero-octameric protein complex that has been proposed to organize vesicle tethering at the Golgi apparatus.
Leslie K Climer +2 more
doaj +1 more source
eLife, 2017 We previously reported that Parkinson’s disease (PD) kinase LRRK2 phosphorylates a subset of Rab GTPases on a conserved residue in their switch-II domains (Steger et al., 2016) (PMID: 26824392). Here, we systematically analyzed the Rab protein family and
Martin Steger +11 more
semanticscholar +1 more source
MOLECULAR MACHINES DETERMINING THE FATE OF ENDOCYTOSED SYNAPTIC VESICLES IN NERVE TERMINALS
Frontiers in Synaptic Neuroscience, 2016 The cycle of a synaptic vesicle (SV) within the nerve terminal is a step-by-step journey with the final goal of ensuring the proper synaptic strength under changing environmental conditions.The SV cycle is a precisely regulated membrane traffic event in ...
Anna eFassio +4 more
doaj +1 more source
Ay, There’s the Rab: Organelle Maturation by Rab Conversion [PDF]
Developmental Cell, 2005 Is endocytosed cargo transported by vesicular intermediates between early and late endosomes, or does an endosome mature while its cargo remains in place? Current work suggests that the latter takes place within the endosomal system via a process termed Rab conversion.
openaire +2 more sources
A conserved and regulated mechanism drives endosomal Rab transition
eLife, 2020 Endosomes and lysosomes harbor Rab5 and Rab7 on their surface as key proteins involved in their identity, biogenesis, and fusion. Rab activation requires a guanine nucleotide exchange factor (GEF), which is Mon1-Ccz1 for Rab7. During endosome maturation,
Lars Langemeyer +8 more
semanticscholar +1 more source
International Journal of Molecular Sciences, 2021 Small guanosine triphosphatases (GTPases) of the Rab and Arf families are key regulators of vesicle formation and membrane trafficking. Membrane transport plays an important role in the central nervous system.
Alazne Arrazola Sastre +4 more
semanticscholar +1 more source
Cancers, 2020 The Rab GTPase family of proteins are mediators of membrane trafficking, conferring identity to the cell membranes. Recently, Rab and Rab-associated factors have been recognized as major regulators of the intracellular positioning and activity of ...
P. D. Gopal Krishnan +4 more
semanticscholar +1 more source
Nove spoznaje o korskim sjedalima u crkvi Uznesenja Blažene Djevice Marije u Rabu
Ars Adriatica, 2019 Istraživanja kasnogotičkih korskih sjedala koja je Hrvatski restauratorski zavod proveo 2018. godine u župnoj crkvi, negdašnjoj katedrali Uznesenja Blažene Djevice Marije u Rabu upućuju na postupan tijek gradnje klupa koji se odvijao u fazama, a dovršen ...
Ksenija Škarić, Vanesa Gjini
doaj +1 more source
Rab GTPase localization and Rab cascades in Golgi transport [PDF]
Biochemical Society Transactions, 2012 Rab GTPases are master regulators of membrane traffic. By binding to distinct sets of effector proteins, Rabs catalyse the formation of function-specifying membrane microdomains. They are delivered to membranes by a protein named GDI (guanine-nucleotide-dissociation inhibitor) and are stabilized there after nucleotide exchange by effector binding.
openaire +2 more sources
Proceedings of the National Academy of Sciences of the United States of America, 2018 Significance LRRK2, a protein kinase related to Parkinson’s disease, is implicated in the maintenance of lysosomes, and a subset of Rab GTPases has been identified as bona fide substrates of LRRK2. Here, we reveal a key stress-responsive pathway composed
T. Eguchi +10 more
semanticscholar +1 more source