Results 51 to 60 of about 73,139 (321)

Rab GTPases: master regulators that establish the secretory and endocytic pathways

Molecular Biology of the Cell, 2017
Several of the most important discoveries in the field of membrane traffic have come from studies of Rab GTPases by Marino Zerial and Peter Novick and their colleagues.
S. Pfeffer
semanticscholar   +1 more source

Mechanisms and regulation of the mitotic inheritance of the Golgi complex

Frontiers in Cell and Developmental Biology, 2015
In mammalian cells, the Golgi complex is structured in the form of a continuous membranous system composed of stacks connected by tubular bridges: the Golgi ribbon.
Carmen eValente, Antonino eColanzi
doaj   +1 more source

TRAPP Complexes in Secretion and Autophagy

Frontiers in Cell and Developmental Biology, 2016
TRAPP is a highly conserved modular multi-subunit protein complex. Originally identified as a transport protein particle with a role in endoplasmic reticulum-to-Golgi transport, its multiple subunits and their conservation from yeast to humans were ...
Jane J Kim, Zhanna eLipatova, Nava eSegev   +2 more
doaj   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Actin dynamics controlled by IqgC, a RasGAP at the crossroads between the IQGAP and fungal GAP1 families

FEBS Open Bio, EarlyView.
IqgC is a RasGAP from Dictyostelium discoideum. IqgC binds RasG via its RasGAP domain and deactivates it on macroendocytic cups, thereby suppressing the uptake of fluid and particles. IqgC has a positive effect on cell‐substratum adhesion, and its RGCt domain is required for recruitment to ventral foci.
Vedrana Filić, Darija Putar, Lucija Mijanović, Igor Weber   +3 more
wiley   +1 more source

Yield performance, adaptability and processing qualities of pre-release potato clones under different Rwandan agro-ecologies

CABI Agriculture and Bioscience, 2022
Five new potato clones (CIP393280.64, CIP393371.58, CIP393077.159, CIP396018.241, and CIP398190.615) and two local checks (Kinigi and Kirundo) were evaluated in fourteen sites under the National Performance Trials (NPTs) for two growing seasons using a ...
Rukundo Placide, Ndacyayisenga Theophile, Elke Vandamme, Nshimiyimana Jean Claude, Mendes Thiago   +4 more
doaj   +1 more source

Patatin‐domain‐containing (phospho)lipases under control: Mammalian co‐regulators and pathogenic activation mechanisms

FEBS Open Bio, EarlyView.
Patatin domain‐containing (phospho)lipases are lipid‐hydrolyzing enzymes central to metabolism, membrane remodeling, and signaling. Their activity relies on precise co‐activation mechanisms involving protein–protein interactions and conformational rearrangements.
Noopur Dubey, Lina Riegler‐Berket, Monika Oberer   +2 more
wiley   +1 more source

Basolateral Endocytic Recycling Requires RAB-10 and AMPH-1 Mediated Recruitment of RAB-5 GAP TBC-2 to Endosomes. [PDF]

PLoS Genetics, 2015
The small GTPase RAB-5/Rab5 is a master regulator of the early endosome, required for a myriad of coordinated activities, including the degradation and recycling of internalized cargo.
Ou Liu, Barth D Grant
doaj   +1 more source

MOFs and COFs in Electronics: Bridging the Gap between Intrinsic Properties and Measured Performance

Advanced Functional Materials, EarlyView.
Metal‐organic frameworks (MOFs) and covalent organic frameworks (COFs) hold promise for advanced electronics. However, discrepancies in reported electrical conductivities highlight the importance of measurement methodologies. This review explores intrinsic charge transport mechanisms and extrinsic factors influencing performance, and critically ...
Jonas F. Pöhls, R. Thomas Weitz
wiley   +1 more source

The pathogen-occupied vacuoles of Anaplasma phagocytophilum and Anaplasma marginale interact with the endoplasmic reticulum

Frontiers in Cellular and Infection Microbiology, 2016
The genus Anaplasma consists of tick-transmitted obligate intracellular bacteria that invade white or red blood cells to cause debilitating and potentially fatal infections. A.
Hilary Kay Truchan, Chelsea Leigh Cockburn, Kathryn Shirley Hebert, Forgivemore eMagunda, Susan Marite Noh, Jason A Carlyon   +5 more
doaj   +1 more source