Results 81 to 90 of about 73,139 (321)
Comprehensive knockout analysis of the Rab family GTPases in epithelial cells
Journal of Cell Biology, 2019 Rab small GTPases (∼60 genes in mammals) are the master regulators of intracellular membrane trafficking. Homma et al. establish a comprehensive collection of knockout epithelial cell lines for all the mammalian Rabs, revealing that Rab6 is required for ...
Y. Homma +8 more
semanticscholar +1 more source
Innovations in microsurgery: The role of non‐invasive blood perfusion imaging—A review and framework
Clinical Advances in Periodontics, EarlyView.Abstract Background This review evaluates current literature on non‐invasive blood perfusion imaging in periodontology, with a focus on applications in periodontal microsurgery. Methods A hypothesis‐building review was conducted by two reviewers from January 2022 to April 2025 across multiple databases. Results Laser speckle contrast imaging (LSCI) and
Amanda B. Rodriguez +3 more
wiley +1 more source
Endosomal Rab cycles regulate Parkin-mediated mitophagy
eLife, 2018 Damaged mitochondria are selectively eliminated by mitophagy. Parkin and PINK1, gene products mutated in familial Parkinson’s disease, play essential roles in mitophagy through ubiquitination of mitochondria.
Koji Yamano +11 more
semanticscholar +1 more source
Catheterization and Cardiovascular Interventions, EarlyView.ABSTRACT Introduction Moderate‐to‐severe calcification is present in ~20%–30% of patients undergoing coronary angiography. Coronary lesion modification is often necessary to facilitate optimal stent delivery and expansion, with several dedicated devices now approved for calcium modification before stent implantation. The CYCLOPES study aims to evaluate
Daniel O'Callaghan +14 more
wiley +1 more source
International Journal of Agricultural Sustainability, 2018 Experiences in smallholder contexts indicate frequent mismatches between technologies introduced and needs of farmers who must make complex decisions in reallocating their limited resources under highly risky ecological and market contexts.
Miyuki Iiyama +8 more
doaj +1 more source
Making Two out of One: Kinesin Motors Driving Plant Cell Division
Cytoskeleton, EarlyView.ABSTRACT The Kinesin superfamily of microtubule dependent motors is present in all eukaryotes. Not all of the subfamilies are represented in all kingdoms, and the ones that are do not always show conserved functions. Tight control of the cytoskeleton is essential for proper progression and completion of mitosis and cytokinesis, and key functions are ...
Choy Kriechbaum, Sabine Müller
wiley +1 more source
EMBO Reports, 2019 RAB GTPases are central modulators of membrane trafficking. They are under the dynamic regulation of activating guanine exchange factors (GEFs) and inactivating GTPase‐activating proteins (GAPs). Once activated, RABs recruit a large spectrum of effectors
Tomas Del Olmo +9 more
semanticscholar +1 more source
In Vivo Cytoskeletal AMPA Receptor Transport Imaging in C. elegans
Cytoskeleton, EarlyView.ABSTRACT Long‐distance intracellular transport of ionotropic glutamate receptors (iGluRs) is essential for proper excitatory synaptic function underlying learning and memory. Many neuropsychiatric and neurodegenerative conditions have abnormal iGluR transport and trafficking, leading to an intense interest in the mechanisms and factors regulating these
Michaelis A. K., Hoerndli F. J.
wiley +1 more source
Small GTPases, 2017 Rab molecular switches are key players in defining membrane identity and regulating intracellular trafficking events in eukaryotic cells. In spite of their global structural similarity, Rab-family members acquired particular features that allow them to ...
O. Pylypenko +3 more
semanticscholar +1 more source