A phorbol ester-binding protein is required downstream of Rab5 in endosome fusion [PDF]
, 1998 Previous observations indicate that a zinc and phorbol ester binding factor is necessary for endosome fusion. To further characterize the role of this factor in the process, we used an in vitro endosome fusion assay supplemented with recombinant Rab5 ...
Mayorga, Luis S +11 more
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Interaction between p85 and Rab5 in the presences and absence of phosphorylated PDGFR peptide [PDF]
, 2012 The adaptor subunit of phosphatidylinositol 3'-kinases (PI3K), p85, is involved in many different biological processes. Recent studies have shown that one of these functions is to serve as a GTPase activating protein (GAP) towards Rab5, a small ...
Bergman, Cody
core
The ubiquitous dermokine delta activates Rab5 function in the early endocytic pathway. [PDF]
, 2011 The expression of the recently identified dermokine (Dmkn) gene leads to four families of proteins with as yet unknown functions. The secreted α, β and γ isoforms share an epidermis-restricted expression pattern, whereas the δ isoform is intracellular ...
Nathalie Jonca +10 more
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Biogenesis of the inner membrane complex is dependent on vesicular transport by the alveolate specific GTPase Rab11B [PDF]
, 2010 Apicomplexan parasites belong to a recently recognised group of protozoa referred to as Alveolata. These protists contain membranous sacs (alveoli) beneath the plasma membrane, termed the Inner Membrane Complex (IMC) in the case of Apicomplexa.
Langsley, G +20 more
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GEF activity of RINL for Rab5 subfamily proteins. [PDF]
, 2012 (A–D) HEK293T cells expressing myc-Rab5b (A), Rab21 (B), Rab22 (C), or Rab31 (D) and FLAG-mock, RINL, RIN3, or Rabex-5 were metabolically radiolabeled with 32Pi for 4 hours.
Shinichi Fukushima (186845) +3 more
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Faster and More Convenient Far-western Blotting for Identifying Rab5-binding Proteins [PDF]
低分子量Gタンパク質Rab5は細胞膜から初期エンドソームへの小胞輸送や初期エンドソーム同士の融合に関与する因子であることが知られている。過去の報告では,GTPγSなどの加水分解耐性GTPアナログを使用しFar-western blottingを行うことによってRab5結合因子が検出されている。しかしながら,この方法ではNEおよびNS反応の際に多量の加水分解耐性GTPアナログが必要であり,実験時間やコストが非常にかかる。本論文ではFar-western ...
HAGIWARA, Makoto +19 more
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GTP CLEAVAGE BY THE SMALL GTP-BINDING PROTEIN RAB3A IS ASSOCIATED WITH EXOCYTOSIS OF SYNAPTIC VESICLES INDUCED BY ALPHA-LATROTOXIN [PDF]
, 1994 STAHL B, Fischer von Mollard G, WALCHSOLIMENA C, JAHN R. GTP CLEAVAGE BY THE SMALL GTP-BINDING PROTEIN RAB3A IS ASSOCIATED WITH EXOCYTOSIS OF SYNAPTIC VESICLES INDUCED BY ALPHA-LATROTOXIN. JOURNAL OF BIOLOGICAL CHEMISTRY.
JAHN, R +3 more
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Characterisation of the involvement of rab5 in early endosome fusion [PDF]
, 1994 The rab5 protein is a member of the rab family of ras-related GTPases, which are known to be involved in the regulation of membrane transport in eukaryotic cells.
Steele-Mortimer, Olivia Ann
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The Arabidopsis Rab5 homologs Rha1 and Ara7 localize to the prevacuolar compartment [PDF]
, 2019 Rha1, an Arabidopsis Rab5 homolog, plays a critical role in vacuolar trafficking in plant cells. In this study, we investigated the localization of Rha1 and Ara7, two Arabidopsis proteins that have highly similar amino acid sequence homology to Rab5 in ...
Sohn, EJ, Lee, GJ, Hwang, I, Lee, MH
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APPL proteins link Rab5 to nuclear signal transduction via an endosomal compartment [PDF]
, 2004 Signals generated in response to extracellular stimuli at the plasma membrane are transmitted through cytoplasmic transduction cascades to the nucleus. We report the identification of a pathway directly linking the small GTPase Rab5, a key regulator of ...
Giner, A. +18 more
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