Results 41 to 50 of about 6,086 (138)
Poly(ADP-ribose) Polymerase 1 Mediates Rab5 Inactivation after DNA Damage [PDF]
, 2022 Parthanatos is programmed cell death mediated by poly(ADP-ribose) polymerase 1 (PARP1) after DNA damage. PARP1 acts by catalyzing the transfer of poly(ADP-ribose) (PAR) polymers to various nuclear proteins. PAR is subsequently cleaved, generating protein-
Nobeyama, Akari +17 more
core +1 more source
2′Halo-ATP and -GTP analogues: Rational phasing tools for protein crystallography [PDF]
, 1999 The solution of the crystallographic macromolecular phase problem requires incorporation of heavy atoms into protein crystals. Several 2′-halogenated nucleotides have been reported as potential universal phasing tools for nucleotide binding proteins ...
Scheidig, A. +5 more
core +1 more source
Journal of Extracellular Vesicles, Volume 15, Issue 1, January 2026.ABSTRACT Idiopathic pulmonary fibrosis (IPF) is a fatal fibrotic lung disease characterized by aberrant myofibroblast activation and excessive extracellular matrix deposition, with extracellular vesicles (EVs) playing a crucial role in this pathological process. We observed that EVs levels are significantly elevated in IPF and positively correlate with
Xiaofan Lai +14 more
wiley +1 more source
Modulation of host cell pathways by Coxiella burnetii Dot/Icm effectors
mLife, Volume 4, Issue 6, Page 577-596, December 2025.Abstract Coxiella burnetii, the etiological agent of Q fever, is a significant intracellular bacterial pathogen. C. burnetii is a highly infectious pathogen that primarily targets pulmonary alveolar macrophages during natural infection. It can then disseminate to macrophages in other tissues and organs, leading to chronic infections. C.
Jingya Yuan +3 more
wiley +1 more source
Glycoproteomics and Its Role in Understanding Bacterial O‐Linked Glycosylation
PROTEOMICS, Volume 25, Issue 21-22, Page 160-176, November 2025.ABSTRACT Protein glycosylation is now recognized as a ubiquitous process observed in all domains of life. Within bacterial species, carbohydrates can be attached to multiple residues with glycosylation of serine, threonine, or tyrosine residues via their hydroxyl side chains referred to as O‐linked glycosylation.
Kristian I. Karlic +2 more
wiley +1 more source
The FASEB Journal, Volume 39, Issue 20, 31 October 2025.Drug‐induced gingival overgrowth involves dysregulation of intracellular collagen degradation. The mechanisms that are involved in the regulation of lysosomal collagenolytic activity are poorly understood. Here, we focus on how cathepsins, Rabs, and V‐ATPases regulate intracellular collagen degradation and, in particular, the vesicular trafficking and ...
Wing Hei Wong +3 more
wiley +1 more source
The regulation of Rab5 by Phosphatidylinositol 3'-Kinase [PDF]
, 2012 Rab5 (Ras-related in brain) and Rab4 are small monomeric GTPases that mediate the intracellular trafficking of endocytosed growth factor receptors. Active Rab5-GTP has low intrinsic GTP hydrolysis activity that is stimulated by GTPase activating proteins
Detillieux, Dielle
core
Characterization of granule-like structures in non-endocrine cells [PDF]
, 2006 All eukaryotic cells have transport pathways to constitutively secrete proteins. Endocrine, neuroendocrine, and exocrine cells in addition have a regulated secretory pathway that serves the controlled release of hormones, neuropeptides or digestive ...
Stettler, Hansruedi
core +1 more source
MedComm, Volume 6, Issue 10, October 2025.This review comprehensively examines the regulatory mechanisms and physiological roles of guanine nucleotide exchange factors (GEFs) and their small GTPase substrates, highlighting their significance in cellular processes and disease pathogenesis.
Zexing Lin +15 more
wiley +1 more source
The synaptic vesicle cluster as a controller of pre‐ and postsynaptic structure and function
The Journal of Physiology, Volume 603, Issue 20, Page 5935-5964, October 15, 2025.Abstract figure legend The synaptic vesicle cluster acts as a master regulator of synaptic structure and function, through various involvements in processes that range from synaptic initiation to plasticity and synaptic loss. Abstract The synaptic vesicle cluster (SVC) is an essential component of chemical synapses, which provides neurotransmitter ...
Sofiia Reshetniak +35 more
wiley +1 more source