Direct binding of vinculin and Rab5. [PDF]
, 2014 (A) Endogenous vinculin and Rab5 were immunoprecipitated from Cos-7 lysates with anti-Rab5 or anti-vinculin antibodies. Vinculin and Rab5 were assayed by western blotting using specific antibodies to vinculin and Rab5.
Makoto Hagiwara (513898) +12 more
core +1 more source
Membrane trafficking of synaptic adhesion molecules
The Journal of Physiology, Volume 603, Issue 20, Page 5921-5934, October 15, 2025.Abstract figure legend Synaptic cellular adhesion molecules are surface transmembrane receptors that have been shown to internalize via endocytosis, and possibly also recycle, in a process that has been linked to the function and the turnover of the synaptic contact site.
Cristian A. Bogaciu, Silvio O. Rizzoli
wiley +1 more source
Interactions of rab5 with cytosolic proteins [PDF]
, 1992 Rab proteins, one of the subfamilies of ras-like small GTP-binding proteins, are attached to cellular compartments or transport vesicles and may determine the specificity of fusion between these compartments and vesicles.
Gorvel, Jean-Pierre +7 more
core
A single discrete Rab5-binding site in phosphoinositide 3-kinase β is required for tumor cell invasion [PDF]
, 2019 Phosphoinositide 3-kinase β (PI3Kβ) is regulated by receptor tyrosine kinases (RTKs), G protein–coupled receptors (GPCRs), and small GTPases such as Rac1 and Rab5.
Gong, Grace Q. +14 more
core +2 more sources
Persistence of quantal synaptic vesicle recycling in virtual absence of dynamins
The Journal of Physiology, Volume 603, Issue 20, Page 6161-6184, October 15, 2025.Abstract figure legend Figure depicts the key finding from this study. While loss of all dynamins severely debilitates synaptic vesicle retrieval following repetitive activity, retrieval and recycling of individual synaptic vesicles following spontaneous fusion or sparse stimulation are minimally affected.
Olusoji A. T. Afuwape +4 more
wiley +1 more source
Modulating Adipogenesis: Key Role of Ras-related Protein Rab5 and its Effectors [PDF]
, 2018 The formation of adipocytes is a complicated process in which insulin and IGF-1 signaling pathways and numerous transcription factors control the conversion of precursor cells to mature fat cells.
Huang, Yongjun
core +2 more sources
Sope acts as an Rab5-specific nucleotide exchange factor and recruits non-prenylated Rab5 on Salmonella-containing phagosomes to promote fusion with early endosomes [PDF]
, 2001 Rab-GTPase regulates the fusion between two specific vesicles. It is well documented that, for their biological function, Rab proteins need to be prenylated for attachment to the vesicle membrane.
Konark Mukherjee +7 more
core +1 more source
Rab5 Activation by the Vps9 Domain [PDF]
, 2007 The movement of proteins through the endocytic pathway is a complex and highly regulated process. Not only is this pathway used to internalize cellular nutrients, but it is also used to modulate a cell's response to extracellular stimuli. Internalization
Carney, Darren Scott
core +1 more source
The R-Ras/RIN2/Rab5 complex controls endothelial cell adhesion and morphogenesis via active integrin endocytosis and Rac signaling [PDF]
, 2012 Carbon nanobuds (CNBs) are a novel nanoscale carbon hybrid material consisting of fullerene-like structures covalently bonded to the outer surface of During developmental and tumor angiogenesis, semaphorins regulate blood vessel navigation by signaling ...
Sandri, Chiara +9 more
core +1 more source
LOCALIZATION OF RAB5 TO SYNAPTIC VESICLES IDENTIFIES ENDOSOMAL INTERMEDIATE IN SYNAPTIC VESICLE RECYCLING PATHWAY [PDF]
, 1994 Fischer von Mollard G, STAHL B, WALCHSOLIMENA C, et al. LOCALIZATION OF RAB5 TO SYNAPTIC VESICLES IDENTIFIES ENDOSOMAL INTERMEDIATE IN SYNAPTIC VESICLE RECYCLING PATHWAY. EUROPEAN JOURNAL OF CELL BIOLOGY.
DECAMILLI, P +8 more
core