Results 21 to 30 of about 6,086 (138)

Computational model explains high activity and rapid cycling of Rho GTPases within protein complexes [PDF]

, 2006
Peer ...
Pokhilko, Alexandra V, Goryachev, Andrew B, Alexandra V Pokhilko, Goryachev Andrew B, Andrew B Goryachev, Pokhilko Alexandra V   +5 more
core   +1 more source

Identification of the Binding Sites on Rab5 and p110beta Phosphatidylinositol 3-kinase [PDF]

, 2017
Rab5 is a small monomeric GTPase that mediates protein trafficking during endocytosis. Inactivation of Rab5 by GTP hydrolysis causes a conformational change that masks binding sites on its “switch regions” from downstream effectors.
Dielle E. Whitecross, Deborah H. Anderson   +1 more
core   +1 more source

Effects of S. aureus on vinculin-Rab5 binding and Rab5-GTP. [PDF]

, 2014
(A) S. aureus was added to the medium of HA-Rab5 (WT)-transfected Cos-7 cells and incubated with S. aureus for the indicated time at 37°C. The cells were lysed and subjected to immunoprecipitation with anti-HA antibody.
Makoto Hagiwara (513898), Kazuyuki Ishihara (513907), Yoshiko Kato (513905), Misako Nakashima (293062), Eitoyo Kokubu (513899), Shinsuke Sugiura (513900), Toshinori Komatsu (513901), Kenji Matsushita (513908), Kaoru Kobayashi (226862), Naoyuki Ishida (513906), Hiroyuki Tada (513902), Naomi Tanigawa (513904), Ryutaro Isoda (513903)   +12 more
core   +1 more source

A cytosolic factor mediating membrane recruitment of AP-1 clathrin adaptors [PDF]

, 2008
Transport of cargo within the endocytic and secretory pathway is generally mediated by coated vesicles. These vesicles are formed through the recruitment of cytosolic coat proteins to the donor membrane that act as a scaffold to form coated buds and ...
Suri, Gregor
core   +1 more source

ANALYSIS OF A NICOTIANA-PLUMBAGINIFOLIA CDNA-ENCODING A NOVEL SMALL GTP-BINDING PROTEIN. [PDF]

, 1992
Small GTP-binding proteins belonging to the Ras superfamily have been found in evolutionarily divergent organisms. Here, we report the isolation and analysis of a cDNA encoding a putative small GTP-binding protein, designated Rhn1, from the plant ...
M. Van Montagu, N. Terryn, D. Inzé, Terryn, Nancy, Anuntalabhochai, S., Terryn, N., Van Montagu, M., Inzé, D., Inzé, Dirk, S. Anuntalabhochai, ANUNTALABHOCHAI, S, Van Montagu, Marc   +11 more
core   +1 more source

Real-time imaging of Leishmania mexicana-infected early phagosomes: a study using primary macrophages generated from green fluorescent protein-Rab5 transgenic mice [PDF]

, 2009
The small GTPase Rab5 is a key regulator of endosome/phagosome maturation and in intravesicular infections marks a phagosome stage at which decisions over pathogen replication or destruction are integrated.
Paape, Daniel, Blackburn, Clare, Lippuner, C., Smith, Andrew, Smith, A. J., Paterou, A., Brand, J., Richardson, Melville, Richardson, M., Blackburn, C., Andrew J. Smith, Volker Brinkmann, Brinkmann, Volker, Janko Brand, Smith, A., Brinkmann, V., Daniel Paape, Toni Aebischer, Brand, Janko, Hoffmann, Kirstin, Hoffmann, K., Athina Paterou, Kirstin Hoffmann, Aebischer, Toni, Paterou, Athina, Paape, D., Clare Blackburn, Smith, Andrew J., Melville Richardson, Aebischer, T., Christoph Lippuner, Lippuner, Christoph   +31 more
core   +1 more source

Pericentrosomal Redistribution of the Endoplasmic Reticulum Ensures Organelle Symmetric Inheritance and Mitotic Progression

Advanced Science, EarlyView.
Upon mitotic entry, RTN4 relocalizes to the pericentrosomal region, forming a more tubular ER network around centrosomes. CDK1‐mediated phosphorylation of RTN4 increases its interaction with Rab11 GTPase, facilitating dynein‐dependent transport of RTN4 to the pericentrosomal region.
Xiangyu Xu, Yalin Liu, Rongyi Wang, Wenwen Xu, Hao Shi, Ning Huang, Junlin Teng, Jin Meng, Pengli Zheng, Jianguo Chen   +9 more
wiley   +1 more source

Cellular localization, accumulation and trafficking of double-walled carbon nanotubes in human prostate cancer cells [PDF]

, 2012
Carbon nanotubes (CNTs) are at present being considered as potential nanovectors with the ability to deliver therapeutic cargoes into living cells. Previous studies established the ability of CNTs to enter cells and their therapeutic utility, but an ...
Silva, S. Ravi P., Coley, Helen M., Neves, V, Flahaut, E, Gerondopoulos, Andreas, Heister, Elena, Neves, Vera, Tîlmaciu, Carmen, Coley, HM, Flahaut, Emmanuel, Gerondopoulos, A, Heister, E, McFadden, J, McFadden, Johnjoe, Soula, Brigitte, Soula, B, Tîlmaciu, C, Silva, SRP   +17 more
core   +1 more source

A Quarter Century of EHD Protein Research: From Endosomal Recycling to Ciliopathies

Traffic, Volume 27, Issue 3, September 2026.
Human EHD protein subcellular localization. ABSTRACT Eps15 homology domain‐containing proteins comprise a conserved family of membrane‐remodeling ATPases that regulate endocytic trafficking, membrane fission, receptor recycling, primary ciliogenesis and membrane dynamics across eukaryotes. Since the initial identification of EHD1 and its Caenorhabditis
Devin Frisby, Gunjan Misri, Naava Naslavsky, Steve Caplan   +3 more
wiley   +1 more source

Study of the role of RAB5-interacting proteins in endocytosis in endothelial cells: study of the role of the interaction between Rab5 and ACAT2 in endocytosis [PDF]

, 2020
Endocytosis is a complex process via which segments of the plasma membrane and extracellular nutrients are internalized via vesicular carriers towards the endolysosomal system. This trafficking pathway is subject to regulation by Rab GTPases.
Γαλανοπούλου, Αικατερίνη, Galanopoulou, Aikaterini   +1 more
core   +1 more source