Results 1 to 10 of about 6,086 (138)

The neuropathy-linked protein TECPR2 is a Rab5 effector that regulates cargo recycling from early endosomes [PDF]

Nature Communications
Small GTP-binding proteins of the Rab, Arf, and Arf-like family mediate the recruitment of their effectors to subcellular membrane-bound compartments, which in turn mediate vesicle budding, motility, and tethering.
Sankalita Paul, Rajat Pant, Poonam Sharma, Kshitiz Walia, Suhasi Gupta, Adhil Aseem, Kamlesh Kumari Bajwa, Ruben George, Yudish Varma, Tripta Bhatia, Rajesh Ramachandran, Amit Tuli, Mahak Sharma   +12 more
doaj   +2 more sources

Development of mRNA–lipid nanoparticle intrabodies against rickettsial infection [PDF]

Journal of Biomedical Science
Background Rickettsiosis is among the deadliest vector-borne infectious diseases worldwide, in part because rickettsiae replicate within human cells, where antibodies and most drugs cannot effectively reach this obligatory intracellular pathogen ...
Qi Yan, Nan Duan, Mingqun Lin, Wenqing Zhang, Stephen Denton, Yichen Zhong, Yizhou Dong, Yasuko Rikihisa   +7 more
doaj   +2 more sources

Developmentally regulated GTP-binding protein 2 coordinates Rab5 activity and transferrin recycling

Molecular Biology of the Cell, 2016
The small GTPase Rab5 regulates the early endocytic pathway of transferrin (Tfn), and Rab5 deactivation is required for Tfn recycling. Rab5 deactivation is achieved by RabGAP5, a GTPase-activating protein, on the endosomes. Here we report that recruitment of RabGAP5 is insufficient to deactivate Rab5 and that developmentally regulated GTP-binding ...
Mani, Muralidharan, Lee, Unn Hwa, Yoon, Nal Ae, Kim, Hyo Jeong, Ko, Myoung Seok, Seol, Wongi, Joe, Yeonsoo, Chung, Hun Taeg, Lee, Byung Ju, Moon, Chang Hoon, Cho, Wha Ja, Park, Jeong Woo   +11 more
openaire   +4 more sources

VPS21 encodes a rab5‐like GTP binding protein that is required for the sorting of yeast vacuolar proteins. [PDF]

The EMBO Journal, 1994
Many of the vacuolar protein sorting (vps) mutants of Saccharomyces cerevisiae exhibit severe defects in the sorting of vacuolar proteins but still retain near-normal vacuole morphology. The gene affected in one such mutant, vps21, has been cloned and found to encode a member of the ras-like GTP binding protein family.
B F, Horazdovsky, G R, Busch, S D, Emr
openaire   +2 more sources

DEEPN as an Approach for Batch Processing of Yeast 2-Hybrid Interactions

Cell Reports, 2016
We adapted the yeast 2-hybrid assay to simultaneously uncover multiple transient protein interactions within a single screen by using a strategy termed DEEPN (dynamic enrichment for evaluation of protein networks).
Natasha Pashkova, Tabitha A. Peterson, Venkatramanan Krishnamani, Patrick Breheny, Mark Stamnes, Robert C. Piper   +5 more
doaj   +1 more source

VipD of Legionella pneumophila targets activated Rab5 and Rab22 to interfere with endosomal trafficking in macrophages.

PLoS Pathogens, 2012
Upon phagocytosis, Legionella pneumophila translocates numerous effector proteins into host cells to perturb cellular metabolism and immunity, ultimately establishing intracellular survival and growth. VipD of L.
Bonsu Ku, Kwang-Hoon Lee, Wei Sun Park, Chul-Su Yang, Jianning Ge, Seong-Gyu Lee, Sun-Shin Cha, Feng Shao, Won Do Heo, Jae U Jung, Byung-Ha Oh   +10 more
doaj   +1 more source

Rab GTPases and phosphoinositides fine-tune SNAREs dependent targeting specificity of intracellular vesicle traffic

Nature Communications
In the secretory pathway the destination of trafficking vesicles is determined by specific proteins that, with the notable exception of SNAREs, are recruited from soluble pools. Previously we have shown that microinjected proteoliposomes containing early
Seiichi Koike, Reinhard Jahn
doaj   +1 more source

Non-canonical and constitutive activation of small GTPases: more than an exception to the rule? [PDF]

Biochem J
Kiers J, Hordijk PL.
europepmc   +1 more source

Endosomal maturation is controlled by the trimeric Bulli-Mon1-Ccz1 Rab7 GEF complex and the Rab5 GTPase-activating protein GAPsec. [PDF]

J Cell Sci
Janz M, Drechsler M, Meyer H, Sriram V, Simes KM, Frommhold E, Füllbrunn N, Langemeyer L, Ungermann C, Kümmel D, Paululat A.   +10 more
europepmc   +1 more source

Rab5 nucleotide binding promotes oxidative metabolism to fuel hepatocellular carcinoma cell proliferation. [PDF]

J Biol Chem
Otakhor KO, Zaidi MAA, Oberley-Deegan RE, Ponnusamy MP, Fisher KW, Schott MB.   +5 more
europepmc   +1 more source