Structural and functional insights into TBC1D17 highlight the importance of the previously uncharacterized Rab-binding domain. [PDF]
Protein SciAbstract TBC (Tre2/Bub2/Cdc16) domain‐containing proteins constitute the widespread family of GTPase‐activating proteins (GAPs). They interact with the Rab superfamily of small GTPases, stimulate GTP hydrolysis, and regulate vesicle trafficking. TBC1D17, involved in Shiga toxin trafficking, autophagy and glucose metabolism regulation, constitutes an ...
Nielipińska D +6 more
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Patatin-domain-containing (phospho)lipases under control: Mammalian co-regulators and pathogenic activation mechanisms. [PDF]
FEBS Open BioPatatin domain‐containing (phospho)lipases are lipid‐hydrolyzing enzymes central to metabolism, membrane remodeling, and signaling. Their activity relies on precise co‐activation mechanisms involving protein–protein interactions and conformational rearrangements.
Dubey N, Riegler-Berket L, Oberer M.
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Rabaptin5 is recruited to endosomes by Rab4a and Rabex5 to regulate endosome maturation [PDF]
, 2014 Membrane trafficking between organelles is fundamental to the existence of eukaryotic cells. A multitude of proteins is involved in membrane trafficking, acting as building blocks for transport carriers, regulators of transport, and targeting and fusion ...
Kälin, Simone
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Characterization of membrane-bound small GTP-binding proteins from Nicotiana tabacum [PDF]
, 1995 Haizel T, Merkle T, Turck F, Nagy F. Characterization of membrane-bound small GTP-binding proteins from Nicotiana tabacum. Plant Physiology.
Haizel, T +7 more
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Specific Rab GTPase-activating proteins define the Shiga toxin and epidermal growth factor uptake pathways [PDF]
, 2007 Rab family guanosine triphosphatases (GTPases) together with their regulators define specific pathways of membrane traffic within eukaryotic cells. In this study, we have investigated which Rab GTPase-activating proteins (GAPs) can interfere with the ...
Evelyn Fuchs +18 more
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Entanglement of plant immunity and endomembrane trafficking revealed by plant-powdery mildew fungal interactions. [PDF]
New PhytolSummary Plant immunity is complex, and studies of leaf epidermal cells attacked by powdery mildew fungi have been instrumental in revealing how it relies on plant endomembrane trafficking. Immunity against these biotrophic fungi is manifested as cell wall deposits (‘papillae’) and the hypersensitive reaction (HR), both involving plant endomembrane ...
Thordal-Christensen H +3 more
europepmc +2 more sources
Recruitment of AP-1 clathrin adaptors to liposomal membranes [PDF]
, 2004 Protein and membrane traffic between organelles within the endocytic and exocytic pathway is mediated most prominently by coated vesicles. These vesicles are formed by the assembly of cytosolic coat proteins onto the donor membrane, which deform it into ...
Meyer, Daniel Markus
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The role of motor proteins in endosomal sorting [PDF]
, 2011 Microtubule motor proteins play key roles in the spatial organization of intracellular organelles as well as the transfer of material between them.
Hunt, Sylvie +3 more
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Analysis of the role or Rab4 and Rab11 in endosomal carrier formation and transferrin recycling [PDF]
, 2012 : In all eukaryotic cells, membrane transport is essential to distribute proteins from the endoplasmic reticulum to their respective destination, i.e. the Golgi, the endosomal/lysosomal system and the cell exterior. A multitude of proteins is involved in
Hirschmann, David
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Transition to Quorum Sensing in an Agrobacterium Population: A Stochastic Model. [PDF]
, 2005 Understanding of the intracellular molecular machinery that is responsible for the complex collective behavior of multicellular populations is an exigent problem of modern biology.
Zhang, Lian-Hui +23 more
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