Results 21 to 30 of about 2,851 (239)

A Cre‐dependent lentiviral vector for neuron subtype‐specific expression of large proteins

FEBS Letters, EarlyView.
We designed a versatile and modular lentivector comprising a Cre‐dependent switch and self‐cleaving 2A peptide and tested it for co‐expression of GFP and a 2.8 kb gene of interest (GOI) in mouse cortical parvalbumin (PV+) interneurons and midbrain dopamine (TH+) neurons.
Weixuan Xue, Sandrine Picaud, Régine Hepp, Stéphanie Pons, Uwe Maskos, Bertrand Lambolez, Ludovic Tricoire   +6 more
wiley   +1 more source

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

PENERAPAN ALGORITMA RSA DAN STREAM CIPHER RABBIT PADA APLIKASI CHATTING [PDF]

, 2015
Layanan instant messaging atau chatting digunakan untuk menunjang komunikasi antar pengguna melalui media internet secara real-time. Salah satu manfaatnya adalah untuk menunjang komunikasi antara pengunjung dengan administrator suatu website sebagai ...
Sarwoko, Eko Adi, Winangsih, Riyan
core  

Substrate specificity of Burkholderia pseudomallei multidrug transporters is influenced by the hydrophilic patch in the substrate‐binding pocket

FEBS Letters, EarlyView.
Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley   +1 more source

The Neuromodulator Adenosine Regulates Oligodendrocyte Migration at Motor Exit Point Transition Zones [PDF]

, 2019
During development, oligodendrocyte progenitor cells (OPCs) migrate extensively throughout the spinal cord. However, their migration is restricted at transition zones (TZs).
Coughenour, Patricia, Fontenas, Laura, Gandhi, Avni V., Kucenas, Sarah, Piller, Melanie, Prober, David A., Welsh, Taylor G.   +6 more
core   +2 more sources

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

Searching a bitstream in linear time for the longest substring of any given density

, 2010
Given an arbitrary bitstream, we consider the problem of finding the longest substring whose ratio of ones to zeroes equals a given value. The central result of this paper is an algorithm that solves this problem in linear time.
Benjamin A. Burton, D.E. Knuth, D.R. Musser, G. Bernardi, G. Marsaglia, K. Chen, L. Duret, M.H. Goldwasser, P. Erdős, P.M. Sharp, R. Arratia, R. Hardison, R.I. Greenberg, S. Boztaş, S. Zoubak, S.M. Fullerton, T.H. Cormen, Y.-H. Hsieh, Y.-L. Lin   +18 more
core   +1 more source

Within the Mainstream. An Ecocritical Framework for Digital Game History [PDF]

, 2017
Ecocriticism of digital games has so far engaged with a rather small corpus of examples, predominantly from a prescriptive perspective and with a quite limited methodological toolkit.
Backe, Hans-Joachim
core   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Contemporary poetic ecologies and a return to form [PDF]

, 2016
Ecology is currently coming under increasing poetic scrutiny in a range of terms (landscape, place, environment). Critical responses to this poetry commonly assume a relationship between form and content, wherein textual ecology – the shape of the poem ...
Adorno, Alexander, Aristotle, Bakhtin, Bate, Bloom, Bloomfield, Brewster, Clark, Collins, Dowson, Eliot, Flint, Gairn, Gander, Garrard, Hadfield, Jamie, Jamie, Kerridge, Macfarlane, Morton, Perloff, Phillips, Pound, Rees-Jones, Sampson, Satterfield, Shapcott, Shapcott, Tarlo, Whatmore, Williams, Williams, Wordsworth   +34 more
core   +2 more sources