Results 41 to 50 of about 483,737 (252)
Molecular Oncology, EarlyView.The pan‐HDAC inhibitor belinostat increases the expression of the pro‐apoptotic proteins Bim, Puma, and Noxa and induces apoptosis in ovarian cancer cell lines and patient‐derived tumor organoids when used at high concentrations. Moreover, inhibiting the anti‐apoptotic proteins Bcl‐xL or Mcl‐1 sensitizes these preclinical models to the cytotoxic effect
Cécilia Thomine +10 more
wiley +1 more source
Multidimensional linear cryptanalysis [PDF]
, 2010 Linear cryptanalysis is an important tool for studying the security of symmetric ciphers. In 1993 Matsui proposed two algorithms, called Algorithm 1 and Algorithm 2, for recovering information about the secret key of a block cipher.
Hermelin, Miia
core
Authenticated Encryption Methods for Feedback Control Systems [PDF]
, 2021 Tilbakekoplingssystemer krever at signaler sendes mellom sensorer, tilstandsestimatorer, regulatorer og aktuatorer. Disse signalene er sårbare for tyvlytting, som gjør at uautoriserte aktører kan få kjennskap til potensielt konfidensielle system- og ...
Solnør, Petter
core
Molecular Oncology, EarlyView.Non‐thermal plasma treatment of melanoma cells induced epithelial‐mesenchymal transition (EMT) in a dose‐dependent fashion. This report highlights the critical need to further investigate potential adverse effects of non‐thermal plasma for cancer therapy and to optimize treatment parameters for clinical translation. Despite the promising results of non‐
Eline Biscop +10 more
wiley +1 more source
Lewis Carrol and Iris Murdoch: dialigue after a century [PDF]
, 2013 The article dwells upon influences of L.Carroll’s Alice in Wonderland in Iris Murdoch’s early novel The Flight from the Enchanter. The analysis is conducted in the terms of inheritance and contradiction with the traditional classical 19th c ...
Isakova, M.L.
core
Within the Mainstream. An Ecocritical Framework for Digital Game History [PDF]
, 2017 Ecocriticism of digital games has so far engaged with a rather small corpus of examples, predominantly from a prescriptive perspective and with a quite limited methodological toolkit.
Backe, Hans-Joachim
core +1 more source
Molecular Oncology, EarlyView.This study identifies nuclear YB‐1 S102 phosphorylation as a marker associated with KRAS and FBXW7 mutations in colorectal cancer. Mutated KRAS correlates specifically with nuclear, not cytoplasmic, S102 YB‐1. These findings provide the first ex vivo evidence of this link in CRC and suggest future studies should assess the prognostic and therapeutic ...
Konstanze Lettau +9 more
wiley +1 more source
A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner
Molecular Oncology, EarlyView.We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp +13 more
wiley +1 more source
M-health review: joining up healthcare in a wireless world [PDF]
, 2012 In recent years, there has been a huge increase in the use of information and communication technologies (ICT) to deliver health and social care. This trend is bound to continue as providers (whether public or private) strive to deliver better care to ...
Adams, Carl +4 more
core +1 more source
Molecular Oncology, EarlyView.C–C chemokine receptor type 9 (CCR9) is an immune checkpoint in pancreatic ductal adenocarcinoma (PDAC). Novel anti‐CCR9 antibody SRB2 was evaluated in combination with cytotoxic chemotherapy in PDAC cells, patient‐derived organoids, patient‐derived xenografts, and humanized mouse models.
Hannah G. McDonald +18 more
wiley +1 more source