Results 61 to 70 of about 6,158,753 (165)

HECTD1 Directs HIF‐1α to Facilitate Intestinal Inflammation and Carcinogenesis via Promoting Th17 Differentiation and Glycolysis

Advanced Science, EarlyView.
HECTD1 emerges as an upstream amplifier of Th17 metabolic programming by promoting K63‐linked ubiquitination of IGF2BP3 and enhancing HIF‐1α translation. HIF‐1α reciprocally drives HECTD1 transcription, establishing a positive regulatory loop that sustains glycolysis and Th17 differentiation.
Shuiyu Xu, Qiaoqiao Han, Feixiang Wang, Yuerong Zhang, Haoran Feng, Kun Liu, Fang Xiu Luo, Fei Yuan, Xuesong Zhao, Xiaoyan Yu, Haiyan Huang, Qiang Zou, Ren Zhao   +12 more
wiley   +1 more source

Rabbit capture histories

, 2018
Individual capture histories by immunity state. "0" = not captured. "N" = captured with no immunity. "M" = captured with myxoma virus immunity, "R" = captured with rabbit haemorrhagic disease virus immunity, "B" = captured with immunity to both rabbit ...
Louise Barnett (264790), Cooke, Brian, Ron Sinclair (4342210), Kovaliski, John, David Peacock (4342198), Corey Bradshaw (377403), Mutze, Gregory, Peacock, David, Brian Cooke (4342201), Barnett, Louise, Prowse, Thomas, Thomas Prowse (5043713), Sinclair, Ron, Bradshaw, Corey, Gregory Mutze (5318768), John Kovaliski (4342207)   +15 more
core   +1 more source

Microbial metabolite indole‐3‐propionic acid preserves astrocytic mitochondrial mitofusin 2 to limit neuroinflammation after traumatic brain injury

Interdisciplinary Medicine, EarlyView.
Following traumatic brain injury, indole‐3‐propionic acid (IPA) directly targets the aryl hydrocarbon receptor on astrocytes in the peri‐lesional cortex; this suppresses interferon regulatory factor 1‐driven transcription of the E3 ubiquitin ligase RFFL (ring finger and FYVE‐like domain containing E3 ubiquitin protein ligase).
Ziwen Zhang, Kai Wang, Liangbo Wang, Wencong Li, Hao Guo, Meng Xu, Tinghao Wang, Jiahui Ren, Ting Zhu, Jiahui Wang, Wenxing Cui, Jinpeng Zhou, Yang Tian, Liying Han, Chengxuan Guo, Shuoyao Ma, Qiang Wang, Zhihong Li, Yaning Cai, Jingyu Dong, Xun Wu, Haixiao Liu, Yan Qu   +22 more
wiley   +1 more source

Rabbit haemorrhagic disease virus Lagovirus europaeus/GI.1d strain: genome sequencing, in vivo virus replication kinetics, and viral dose effect

BMC Veterinary Research, 2021
Background Rabbit haemorrhagic disease virus Lagovirus europaeus/GI.1d variant (GI.1d/RHDV) was identified in 1990 in France, and until the emergence of the new genotype GI.2, it was the main variant circulating in the country.
Clément Droillard, Evelyne Lemaitre, Michel Amelot, Yannick Blanchard, Alassane Keita, Nicolas Eterradossi, Ghislaine Le Gall-Reculé   +6 more
doaj   +1 more source

Gut microbiota dysbiosis‐mediated gut NLRP3 inflammasome activation exacerbates corticospinal tract injury after intracerebral hemorrhage

Interdisciplinary Medicine, EarlyView.
Schematic depicting a gut‐brain pathway that exacerbates CST injury after ICH. Gut Microbiota Dysbiosis‐Mediated Gut NLRP3 Inflammasome Activation Exacerbates Corticospinal Tract Injury After Intracerebral Hemorrhage. Abstract Intracerebral hemorrhage (ICH) causes severe neurological deficits largely attributable to corticospinal tract (CST) injury ...
Meiqin Zeng, Meichang Peng, Chen He, Yanmeng Zhao, Zizhang Cheng, Mengchen Yu, Hao Tian, Lu Zhang, Wen Yuan, Qing Zeng, Jiandong Huang, Haitao Sun   +11 more
wiley   +1 more source

Long‐term outcomes of haploidentical hematopoietic stem cell transplantation with antithymocyte globulin–based myeloablative conditioning in pediatric refractory or relapsed non‐Hodgkin lymphoma

Pediatric Investigation, EarlyView.
Single‐center retrospective data showed that ATG‐based myeloablative haploidentical hematopoietic stem cell transplantation provides durable remission and favorable long‐term survival in children with refractory/relapsed non‐Hodgkin lymphoma, achieving high engraftment rates, low relapse incidence, and acceptable toxicity.
Chenguang Jia, Jie Zheng, Meng Yuan, Hongbo He, Yibo Fan, Bin Wang, Guanghua Zhu, Jun Yang, Yanhui Luo, Lixiao Cai, Pan Zhang, Yanlong Duan, Maoquan Qin   +12 more
wiley   +1 more source

Distribution and prevalence of the Australian non-pathogenic rabbit calicivirus is correlated with rainfall and temperature. [PDF]

PLoS ONE, 2014
BACKGROUND: Australia relies heavily on rabbit haemorrhagic disease virus (RHDV) for the biological control of introduced European wild rabbits Oryctolagus cuniculus, which are significant economic and environmental pests.
June Liu, Damien A Fordham, Brian D Cooke, Tarnya Cox, Greg Mutze, Tanja Strive   +5 more
doaj   +1 more source

PATHOGENESIS OF LOCAL ISOLATE OF RABBIT HAEMORRHAGIC DISEASE VIRUS (RHDV) IN BALADY RABBITS AND CELL CULTURE [PDF]

Veterinary Medical Journal - Giza, 2002
The Balady rabbif) were I/N experimentally inFected with RHDV to study the pathogenesis of The virus. The virus induced 100% morbidity and mortality. The virus antigen(s) were detected in Liver, spleen, lung, heart and kidney by HA, AGPT AND FAT.
H MADBOULY, M KHODEIR, A MOSTAFA
doaj   +1 more source

Apigenin Protects Hypertensive Intracerebral Hemorrhage by Regulating Trx1 Through Binding to PRDX2

Phytotherapy Research, EarlyView.
ABSTRACT Intracerebral hemorrhage (ICH) remains the most severe stroke subtype with high mortality and disability rates. Although apigenin has shown cerebroprotective potential in preclinical studies, its mechanism of action, particularly in hypertensive ICH, remains poorly understood.
Hao‐chen Xu, Ming Liu, Ying‐ying Sun, Jie‐Dan Ping, Qing‐hua Cui, Jing‐zhou Chen, Hao Li   +6 more
wiley   +1 more source

Biology, ecology, and conservation of the Italian hare Lepus corsicanus: a review

Wildlife Biology, EarlyView.
The Italian hare Lepus corsicanus, an endemic lagomorph of Italy, serves as a critical case study in evolutionary biology and conservation. Once taxonomically debated, modern genetic and morphological analyses confirm its status as a distinct Pleistocene lineage restricted to the central‐southern Italian Peninsula and Sicily.
Pierangelo Freschi, Valter Trocchi
wiley   +1 more source