Results 81 to 90 of about 24,359 (148)

Torque teno virus as a marker of immune status in immunocompromised patients: A systematic review

European Journal of Clinical Investigation, EarlyView.
Abstract Background Torque teno virus (TTV) is not known to cause disease in humans; however, chronic inflammatory conditions and immunosuppression states can favour TTV replication. This study aimed to verify the effectiveness of TTV as an immune biomarker.
Janaina B. Medina, Fábio França Vieira e Silva, Rafael Antônio Velôso Caixeta, Bruna de Oliveira Rech, Alba Perez‐Jardón, María Elena Padín‐Iruegas, Mario Pérez‐Sayáns, Paulo Henrique Braz‐Silva, Karem L. Ortega   +8 more
wiley   +1 more source

Techniques for subretinal injections in animals

Veterinary Ophthalmology, Volume 28, Issue 2, Page 506-518, March 2025.
Abstract Subretinal injections are not commonly performed during clinical treatment of animals but are frequently used in laboratory animal models to assess therapeutic efficacy and safety of gene and cell therapy products. Veterinary ophthalmologists are often employed to perform the injections in the laboratory animal setting, due to knowledge of ...
Ryan F. Boyd, Simon M. Petersen‐Jones
wiley   +1 more source

Gut‐derived Lactobacillus from exceptional responders mitigates chemoradiotherapy‐induced intestinal injury through methionine‐driven epigenetic modulation

iMeta, Volume 4, Issue 3, June 2025.
Using metagenomic sequencing and bioinformatics analysis of fecal samples from rectal cancer patients and corresponding mouse models, our study identifies a strong association between Lactobacillus abundance and acute chemoradiotherapy‐induced intestinal injury (ACRIII). Elevated Lactobacillus levels before treatment were consistently linked to reduced
Lu Yu, Zhenhui Chen, Shengqi Yin, Qiqing Guo, Yuchuan Chen, Jiaying Li, Yafang Wang, Xiangqiang Liu, Zi Xu, Yaowei Zhang, Yuqin Zhang, Zhihao Zheng, Keli Chen, Yanqing Ding, Hongying Fan, Zhifeng Liu, Yi Ding   +16 more
wiley   +1 more source

Development of CpG-oligodeoxynucleotides for effective activation of rabbit TLR9 mediated immune responses. [PDF]

PLoS ONE, 2014
CpG-oligodeoxynucleotides (CpG-ODN) are potent immune stimuli being developed for use as adjuvants in different species. Toll-like receptor 9 (TLR9) is the cellular receptor for CpG-ODN in mammalian cells. The CpG-ODN with 18-24 deoxynucleotides that are
Tsung-Hsien Chuang, Chao-Yang Lai, Ping-Hui Tseng, Chiun-Jye Yuan, Li-Chung Hsu   +4 more
doaj   +1 more source

CXCL10highTNFαhighKi67+ Microglia Recruit and Activate CD8+ T Cells in the Brainstem During Experimental Cerebral Malaria

CNS Neuroscience &Therapeutics, Volume 31, Issue 6, June 2025.
Microglia exhibit distinct transcriptional and morphological heterogeneity in experimental cerebral malaria (ECM) compared to physiological microglia. A unique subtype of ECM‐associated microglia, characterized by CXCL10highTNFαhighKi67+, mediates the recruitment and sustained activation of CD8+ T cells through ongoing interactions, exacerbating ...
Yi Wang, Jiao Liang, Chao Yang, Jun Wang, Qinghao Zhu, Guodong Tong, Tong Li, Ganze Li, Yuxiao Huang, Yimin Yang, Jie Ren, Yinghui Li, Yan Shen, Ya Zhao   +13 more
wiley   +1 more source

Advancing the Identification of Bioactive Molecules and the Construction of a Synergistic Drug Delivery System in Combating Lung Injury

Advanced Science, Volume 12, Issue 18, May 15, 2025.
Traditional Chinese Medicine (TCM), while holistic and historically esteemed, faces challenges in “miracle cures” due to slow onset, long cycles, and difficulty controlling quality. This study obtains the active ingredients, glabridin (GLA) and puerarin (PUE), from Ge‐Gen Decoction (GGD), developing a safe and effective drug delivery system, GLA‐PUE ...
Jianhong Qi, Yanxia Wang, Huan Chen, Kaitian Wu, Pei Zhou, Yue Dou, Bingqi Xiong, Wei Zhou   +7 more
wiley   +1 more source

Mas Signaling Potentiates Neutrophil Extracellular Traps Formation Induced by Endothelial Cells Derived S1P in Mice with Acute Liver Failure

Advanced Science, Volume 12, Issue 20, May 29, 2025.
In mice challenged with lipopolysaccharide/D‐galactosamine (L/G), Mas signaling increased SHP2 in hepatic Col4a1+ endothelial cells, inhibiting farnesoid X receptor (FXR), potentially due to enterogenic deoxycholic acid. This inhibition activates sphingosine‐1‐phosphate‐induced Raf/MEK/ERK signaling in Cldn1+CD177+ neutrophils, causing neutrophil ...
Bo Yang, Shuai Chen, Xiaoqi Xia, Ziwen Tao, Chun Liu, Shanshan Li, Shuo Zhang, Jiali Huang, Lu Xia, Wenqiang Quan, Changqing Yang, Jing Li   +11 more
wiley   +1 more source

Overcoming species barriers: an outbreak of Lagovirus europaeus GI.2/RHDV2 in an isolated population of mountain hares (Lepus timidus)

BMC Veterinary Research, 2018
Background Prior to 2010, the lagoviruses that cause rabbit hemorrhagic disease (RHD) in European rabbits (Oryctolagus cuniculus) and European brown hare syndrome (EBHS) in hares (Lepus spp.) were generally genus-specific.
Aleksija S. Neimanis, Harri Ahola, Ulrika Larsson Pettersson, Ana M. Lopes, Joana Abrantes, Siamak Zohari, Pedro J. Esteves, Dolores Gavier-Widén   +7 more
doaj   +1 more source

Autologous Nonmyeloablative Hematopoietic Stem Cell Transplantation for Diffuse Cutaneous Systemic Sclerosis: Identifying Disease Risk Factors for Toxicity and Long‐Term Outcomes in a Prospective, Single‐Arm Trial

Arthritis &Rheumatology, Volume 77, Issue 5, Page 571-581, May 2025.
Objective Two randomized trials for patients with diffuse systemic sclerosis (SSc) demonstrated an overall survival (OS) and event‐free survival (EFS) advantage of autologous hematopoietic stem cell transplantation (AHSCT) using CD34+ selected peripheral blood stem cells (PBSCs) compared with monthly cyclophosphamide (CY).
George E. Georges, Dinesh Khanna, Mark H. Wener, Matthew G. Mei, Maureen D. Mayes, Robert W. Simms, Vaishali Sanchorawala, Chitra Hosing, Suzanne Kafaja, Attaphol Pawarode, Leona A. Holmberg, Jason Kolfenbach, Daniel E. Furst, Keith M. Sullivan, Suiyuan Huang, Ted Gooley, Richard A. Nash   +16 more
wiley   +1 more source

Dihydroartemisinin Attenuates Radiation‐Induced Lung Injury by Inhibiting the cGAS/STING/NF‐κB Signaling Pathway

Drug Development Research, Volume 86, Issue 3, May 2025.
ABSTRACT Dihydroartemisinin (DHA) is a derivative of artemisinin, which affects inflammation, oxidative stress, and immune regulation. However, the mechanism underlying its effects remains largely unknown. This study aims to explore the mechanism by which DHA affects radiation‐induced lung injury (RILI), providing new insights for lung radiotherapy. To
Cailan Wang, Xinyi Lin, Shichun Guan, Qiaoyuan Wu, Shixiong Liang   +4 more
wiley   +1 more source