Results 71 to 80 of about 6,254,510 (175)

NCOA4 Accelerates Abdominal Aortic Aneurysm Formation by Regulating Macrophage Activation and Ferroptosis via STAT1–CH25H Axis

Advanced Science, EarlyView.
Under pathological stimulation, NCOA4 in macrophages interacts with STAT1 to promote CH25H transcription. The subsequent increase in 25‐HC production activates macrophages, triggers inflammatory responses and ferroptosis, and accelerates the progression of AAA.
Zhinan Wu, Yuxuan Qian, Wenyi Xu, Fei Liao, Xueliang Liu, Xiao Kuang, Guqing Luo, Xinjie He, Lixian Jiang, Song Ding   +9 more
wiley   +1 more source

scH16S‐Seq Maps Klebsiella pneumoniae‐Associated Myeloid States and Reveals a CD38–NAD Immunometabolic Axis That Impairs Lysosomal Acidification in Sepsis

Advanced Science, EarlyView.
Single‐cell host–bacterial 16S co‐sequencing (scH16S‐seq) integrates cell‐associated bacterial 16S‐derived signals with host transcriptomes to resolve bacterial signal‐enriched myeloid states in Klebsiella pneumoniae sepsis. Complementary pharmacological and genetic analyses define a CD38–NAD immunometabolic axis connecting mitochondrial bioenergetic ...
Yangguang Li, Yilong Yu, Fang Qin, Shenxing Li, Xuanheng Li, Peizhao Liu, Juanhan Liu, Haiqing Liu, Songqi Jing, Jianghao Zou, Sicheng Li, Jiayang Li, Tao Zheng, Yun Zhao, Jianan Ren, Xiuwen Wu   +15 more
wiley   +1 more source

Rabbit Hemorrhagic Disease [PDF]

, 2016
Rabbit hemorrhagic disease is a serious and extremely contagious viral disease of domesticated and wild rabbits. Morbidity and mortality rates are high in unvaccinated animals; on some farms, most or all of the rabbits may die.

core  

Immunological Cross-Protection between Different Rabbit Hemorrhagic Disease Viruses—Implications for Rabbit Biocontrol and Vaccine Development

Vaccines, 2022
The use of rabbit hemorrhagic disease virus (RHDV) as a biocontrol agent to control feral rabbit populations in Australia, in combination with circulating endemic strains, provides a unique environment to observe the interactions between different ...
Tiffany W. O’Connor, Andrew J. Read, Robyn N. Hall, Tanja Strive, Peter D. Kirkland   +4 more
doaj   +1 more source

HECTD1 Directs HIF‐1α to Facilitate Intestinal Inflammation and Carcinogenesis via Promoting Th17 Differentiation and Glycolysis

Advanced Science, EarlyView.
HECTD1 emerges as an upstream amplifier of Th17 metabolic programming by promoting K63‐linked ubiquitination of IGF2BP3 and enhancing HIF‐1α translation. HIF‐1α reciprocally drives HECTD1 transcription, establishing a positive regulatory loop that sustains glycolysis and Th17 differentiation.
Shuiyu Xu, Qiaoqiao Han, Feixiang Wang, Yuerong Zhang, Haoran Feng, Kun Liu, Fang Xiu Luo, Fei Yuan, Xuesong Zhao, Xiaoyan Yu, Haiyan Huang, Qiang Zou, Ren Zhao   +12 more
wiley   +1 more source

Serosurvey on household contacts of Marburg hemorrhagic fever patients. [PDF]

, 2006
The first major outbreak of Marburg hemorrhagic fever (MHF) outside a laboratory environment occurred in the subdistrict of Watsa, Democratic Republic of Congo, from October 1998 to August 2000.
MULANGU, S, TSHOMBA, A, Muyembe-Tamfum, J. J., Robert Swanepoel, Van der Stuyft, Patrick, Jean-Jacques Muyembe-Tamfum, LIBANDE, ML, Muyembe-Tamfum, Jean-Jacques, SWANEPOEL, R, Matthias Borchert, Kulidri, Amayo, Tshomba, Antoine, MUYEMBE-TAMFUM, JJ, Modeste Lifenya Libande, BORCHERT, M, Antoine Tshomba, Borchert, M., Tshomba, A., Van der Stuyft, P., Libande, M. L., Libande, Modeste Lifenya, Kulidri, A., Amayo Kulidri, Mulangu, Sabue, Mulangu, S., Sabue Mulangu, KULIDRI, A, Swanepoel, R., Patrick Van der Stuyft, Borchert, Matthias, Swanepoel, Robert   +30 more
core   +1 more source

Microbial metabolite indole‐3‐propionic acid preserves astrocytic mitochondrial mitofusin 2 to limit neuroinflammation after traumatic brain injury

Interdisciplinary Medicine, EarlyView.
Following traumatic brain injury, indole‐3‐propionic acid (IPA) directly targets the aryl hydrocarbon receptor on astrocytes in the peri‐lesional cortex; this suppresses interferon regulatory factor 1‐driven transcription of the E3 ubiquitin ligase RFFL (ring finger and FYVE‐like domain containing E3 ubiquitin protein ligase).
Ziwen Zhang, Kai Wang, Liangbo Wang, Wencong Li, Hao Guo, Meng Xu, Tinghao Wang, Jiahui Ren, Ting Zhu, Jiahui Wang, Wenxing Cui, Jinpeng Zhou, Yang Tian, Liying Han, Chengxuan Guo, Shuoyao Ma, Qiang Wang, Zhihong Li, Yaning Cai, Jingyu Dong, Xun Wu, Haixiao Liu, Yan Qu   +22 more
wiley   +1 more source

Pulmonary vein aneurysm in a New Zealand White rabbit: a case report

Laboratory Animal Research, 2022
Background Pulmonary venous aneurysm (PVA) is a rare condition characterized by aneurysmal dilatation of the pulmonary vein in humans. The diagnosis is incidental usually as there are no clinical symptoms.
Jong-Min Kim, Chang Gok Woo, Sa Hun Kim, Eui-Suk Jeong, Kil-Soo Kim, Byeong-Cheol Kang   +5 more
doaj   +1 more source

Gut microbiota dysbiosis‐mediated gut NLRP3 inflammasome activation exacerbates corticospinal tract injury after intracerebral hemorrhage

Interdisciplinary Medicine, EarlyView.
Schematic depicting a gut‐brain pathway that exacerbates CST injury after ICH. Gut Microbiota Dysbiosis‐Mediated Gut NLRP3 Inflammasome Activation Exacerbates Corticospinal Tract Injury After Intracerebral Hemorrhage. Abstract Intracerebral hemorrhage (ICH) causes severe neurological deficits largely attributable to corticospinal tract (CST) injury ...
Meiqin Zeng, Meichang Peng, Chen He, Yanmeng Zhao, Zizhang Cheng, Mengchen Yu, Hao Tian, Lu Zhang, Wen Yuan, Qing Zeng, Jiandong Huang, Haitao Sun   +11 more
wiley   +1 more source

Pancreas–Intestine Composite Transplantation for Simultaneous Loss of Pancreatic and Intestinal Function (With Video)

Journal of Hepato-Biliary-Pancreatic Sciences, EarlyView.
ABSTRACT Pancreas–intestine composite transplantation (PITx) is a therapeutic option for patients with irreversible loss of both pancreatic and intestinal function. We report a case of PITx in a 16‐year‐old male who developed fulminant Type 1 diabetes mellitus complicated by non‐occlusive mesenteric ischemia, resulting in extensive intestinal necrosis.
Kei Yamane, Takashi Ito, Takayuki Anazawa, Junji Fujikura, Makoto Okabe, Satoshi Ishida, Koki Kurahashi, Masaaki Hirata, Hiroshi Kawamoto, Hiroto Nishino, Asahi Sato, Tomoaki Yoh, Hidenobu Kojima, Shinya Okumura, Takahiro Nishio, Daisuke Ueda, Hirofumi Hirao, Yuki Masano, Shoichi Kageyama, Katsunori Sakamoto, Satoshi Ogiso, Kazuyuki Nagai, Yoichiro Uchida, Takamichi Ishii, Etsuro Hatano   +24 more
wiley   +1 more source