Results 81 to 90 of about 71,357 (285)

Nanoparticle‐encapsulated neuropeptide Y provides robust seizure protection in SCN1A‐derived epilepsy

Epilepsia, EarlyView.
Abstract Objective Neuropeptides have garnered great interest as potential treatments for epilepsy due to their impact on neuronal excitability through modulation of ion channels and neurotransmitter receptor activity. Neuropeptide Y (NPY) is a 36‐amino acid neuropeptide that is expressed primarily by γ‐aminobutyric acidergic (GABAergic) interneurons ...
Samantha L. Reed, Lauren M. Aiani, Eesha Faiz, Emmanuel Adediran, Morris Benveniste, Kevin S. Murnane, Martin D'Souza, Andrew Escayg, Jennifer C. Wong   +8 more
wiley   +1 more source

Rabies virus glycoprotein variants display different patterns in rabies monosynaptic tracing

Frontiers in Neuroanatomy, 2014
Rabies virus (RV) has been widely used to trace multi-synaptic neuronal circuits. The recent development of glycoprotein-deficient rabies virus (RV-ΔG) expressing various proteins has enabled analyses of both the structure and function of neuronal ...
Takuma eMori, Kinjiro eMorimoto
doaj   +1 more source

In vitro and in vivo evaluation of a single chain antibody fragment generated in planta with potent rabies neutralisation activity. [PDF]

, 2019
Rabies causes more than 60,000 human deaths annually in areas where the virus is endemic. Importantly, rabies is one of the few pathogens for which there is no treatment following the onset of clinical disease with the outcome of infection being death in
Andersen, Anthony R. Fooks, Ashley C. Banyard, Bien-Ly, Boado, Boado, Both, Both, Burrage, Christophe Prehaud, Colin P.D. Birch, David Selden, Donnelly-Roberts, Eigenmann, Fangtao, Fu, Guanghui Wu, Hanlon, Hemachudha, Huang, Johnson, Julian K.-C. Ma, Kaplan, Kim, Kristensen, Kumar, Lafon, Lafon, Lentz, Lentz, Lentz, Lentz, Lewis, Li, Markoutsa, Megret, Meng, Monique Lafon, Morimoto, Muller, Niewoehner, Pardridge, Pardridge, Phoolcharoen, Phoolcharoen, Portioli, Rip, Schnell, Shantavasinkul, Teh, Thoulouze, Tian, Tim H. Szeto, Uwanyiligira, Velasco-Aguirre, Waranyoo Phoolcharoen, Warrell, Weksler, Xiang, Yamauchi, Zhang   +60 more
core   +3 more sources

Aural plaques: Considerations on autohaemotherapy treatment in four Mangalarga Marchador crossbred horses

Equine Veterinary Education, EarlyView.
Summary The occurrence of Aural Plaques (AP) in horses, attributed to infection with Equus caballus Papillomavirus (EcPV), has become increasingly prevalent in equine breeding populations. Major challenges in managing this condition include genetic susceptibility to the virus, significant variability in individual immune responses among horses and the ...
E. Bastianetto, M. I. de Azevedo, I. S. Ferrão, P. Fantini, E. M. M. Lima, M. B. Castro, C. B. de Melo   +6 more
wiley   +1 more source

Protection Against CNS-Targeted Rabies Virus Infection is Dependent upon Type-1 Immune Mechanisms Induced by Live-Attenuated Rabies Vaccines

Tropical Medicine and Infectious Disease, 2017
Rabies remains a major public health issue worldwide, especially in developing countries where access to medical care can represent a real challenge. While there is still no cure for rabies, it is a vaccine-preventable disease with pre- and post-exposure
Aurore Lebrun, Samantha Garcia, Jianwei Li, Rhonda B. Kean, D. Craig Hooper   +4 more
doaj   +1 more source

Borna disease virus infection: Retrospective case series of five horses and two donkeys in Switzerland

Equine Veterinary Education, EarlyView.
Summary Borna disease is an acute to subacute, rarely chronic non‐purulent meningoencephaylomyelitis affecting mainly horses and sheep. This case series describes the clinical signs, diagnosis, treatment, outcome and post‐mortem findings of five horses and two donkeys with this condition. The equids affected were geldings or mares of various breeds and
I. L. Piotrowski, M. Hilbe, H. K. Junge
wiley   +1 more source

Sufficient virus-neutralizing antibody in the central nerve system improves the survival of rabid rats

Journal of Biomedical Science, 2012
Background Rabies is known to be lethal in human. Treatment with passive immunity for the rabies is effective only when the patients have not shown the central nerve system (CNS) signs.
Liao Pi-Hung, Yang Hui-Hua, Chou Ping-Tse, Wang Ming-Hseng, Chu Po-Chun, Liu Hao-Li, Chen Li-Kuang   +6 more
doaj   +1 more source

Sequencing of rabies binding region on nicotinic acteylcholine receptor alpha subunits in four host species [PDF]

, 2013
• Rabies virus is known to bind to nicotinic acetylcholine receptors (nAchR) • The virus is known to bind to alpha 1 subunits nAchR • The virus binding region has been characterized in alpha 1 subunits of these receptors • Little research has been ...
Barnard, Karen
core  

Zoonotic anxieties: The cultural politics of Nepal's quest for pandemic preparedness

Medical Anthropology Quarterly, EarlyView.
Abstract Based on fieldwork conducted in Nepal (2022–2024) and by paying attention to how local and transnational notions of epidemiological risk are deployed, this ethnography introduces the concept of “zoonotic anxieties” to make sense of the multi‐species relational ethos that contemporary global health regimes propose.
Max D. López Toledano, Hari Basnet, Anna Durrance‐Bagale, Natasha Howard   +3 more
wiley   +1 more source

Recent optical approaches for anatomical and functional dissection of neuron–astrocyte circuitry

The Journal of Physiology, EarlyView.
Abstract figure legend This review summarises novel optical approaches to deciphering structural and functional wiring diagrams of neuron–astrocyte circuits in the brain. There are three groups: the anatomical proximity assay, transsynaptic viral tracing and the functional connection assay. The FRET‐based neuron–astrocyte proximity assay allows mapping
Yoshiki Hatashita, Takafumi Inoue
wiley   +1 more source