Autism spectrum disorder-associated Sema5A p.Arg676Cys drives Arf6/FE65 signaling and aberrant cell morphogenesis [PDF]
Scientific ReportsAutism spectrum disorder (ASD) is a neurodevelopmental condition characterized by impairments in social interaction, challenges with communication, and repetitive behaviors.
Mikito Takahashi +5 more
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Rac1 in gastric cancer: a molecular driver of invasion, EMT, and therapeutic resistance [PDF]
Journal of Translational MedicineGastric cancer (GC) ranks as the fifth most common cancer worldwide and is the third main cause of cancer-related mortality, posing a substantial burden to global public health.
Jianwen Li +5 more
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Rho/ROCK Signaling Pathway in Kidney Diseases: Mechanisms and Therapeutic Perspectives [PDF]
BiomedicinesRho GTPases are a group of guanosine triphosphate (GTP)-binding proteins with a relative molecular weight of about 20–30 kD, and 22 different Rho GTPases have been identified in mammalian cells, among which RhoA, Rac1 and Cdc42 are the most well-studied.
Wei Xiong +4 more
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Research progress in the relationship between PREX1 gene and tumor pathogenesis [PDF]
Xin yixue, 2023 Phosphatidylinositol-3， 4， 5-triphosphate-dependent Rac exchange factor 1 （PREX1） is a coding gene that is abnormally expressed in a variety of tumors. As a guanine nucleotide exchange factor （RacGEF） of small GTP binding protein Rac1， PREX1 gene-encoded
Chen Ting, Zhou Yu
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Frontiers in Chemistry, 2021 Rac1 is a small signaling protein, which belongs to the Rho subfamily of Ras superfamily. It is activated by binding GTP and inactivated by exchanging GDP for GTP.
Chunwen Zheng +10 more
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The Small GTPase CsRAC1 Is Important for Fungal Development and Pepper Anthracnose in [PDF]
The Plant Pathology Journal, 2021 The pepper anthracnose fungus, Colletotrichum scovillei, causes severe losses of pepper fruit production in the tropical and temperate zones. RAC1 is a highly conserved small GTP-binding protein in the Rho GT-Pase family.
Noh-Hyun Lee +5 more
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Frontiers in Immunology, 2021 BackgroundImpaired intestinal barrier integrity plays a crucial role in the development of many diseases such as obesity, inflammatory bowel disease, and type 2 diabetes.
Guangmang Liu +33 more
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Akt Protein Kinase Inhibits Rac1-GTP Binding through Phosphorylation at Serine 71 of Rac1 [PDF]
Journal of Biological Chemistry, 2000 A putative Akt kinase phosphorylation site ((64)ydRIRplSYp(73)) was found in Rac1/CDC42 and Rho family proteins (RhoA, RhoB, RhoC, and RhoG). Phosphorylation of Rac1 by Akt kinase was assayed with recombinant Rac1 protein and the fluorescein-labeled Rac1 peptide.
T, Kwon +4 more
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Expression Analysis of the Small GTP-Binding Protein Rac in Pterygium
Türk Oftalmoloji Dergisi, 2023 Objectives: To determine the roles of small GTP-binding proteins Rac1, Rac2, and Rac3 expression in pterygial tissue and to compare these expressions with normal conjunctival tissue.
Ahmet Saracaloğlu +6 more
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K-Ras mediated murine epidermal tumorigenesis is dependent upon and associated with elevated Rac1 activity. [PDF]
PLoS ONE, 2011 A common goal for potential cancer therapies is the identification of differences in protein expression or activity that would allow for the selective targeting of tumor vs. normal cells. The Ras proto-oncogene family (K-Ras, H-Ras and N-Ras) are amongst
Michael S Samuel +2 more
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