Results 21 to 30 of about 22,107 (146)

EGF-induced nuclear translocation of SHCBP1 promotes bladder cancer progression through inhibiting RACGAP1-mediated RAC1 inactivation

Cell Death and Disease, 2022
Bladder cancer is a highly heterogeneous and aggressive malignancy with a poor prognosis. EGF/EGFR activation causes the detachment of SHC-binding protein 1 (SHCBP1) from SHC adapter protein 1 (SHC1), which subsequently translocates into the nucleus and ...
Hubin Yin, Chen Zhang, Zongjie Wei, Weiyang He, Ning Xu, Yingjie Xu, Tinghao Li, Ke Ren, Youlin Kuang, Xin Zhu, Fangchao Yuan, Haitao Yu, Xin Gou   +12 more
doaj   +1 more source

Tripartite split-GFP assay to identify selective intracellular nanobody that suppresses GTPase RHOA subfamily downstream signaling

Frontiers in Immunology, 2022
Strategies based on intracellular expression of artificial binding domains present several advantages over manipulating nucleic acid expression or the use of small molecule inhibitors.
Laura Keller, Laura Keller, Claudine Tardy, Laetitia Ligat, Soazig Le Pennec, Nicolas Bery, Faten Koraïchi, Patrick Chinestra, Mélissa David, Rémi Gence, Gilles Favre, Gilles Favre, Stéphanie Cabantous, Aurélien Olichon, Aurélien Olichon   +14 more
doaj   +1 more source

The Small GTP-binding Protein Rac1 Induces Cardiac Myocyte Hypertrophy through the Activation of Apoptosis Signal-regulating Kinase 1 and Nuclear Factor-κB [PDF]

Journal of Biological Chemistry, 2003
The small guanine nucleotide-binding protein Rac1 has emerged as an important molecule involved in cardiac myocyte hypertrophy. Recently, we reported on apoptosis signal-regulating kinase (ASK) 1 and a transcriptional factor, nuclear factor-kappaB (NF-kappaB), as novel signaling intermediates in cardiac myocyte hypertrophy.
Yoshiharu, Higuchi, Kinya, Otsu, Kazuhiko, Nishida, Shinichi, Hirotani, Hiroyuki, Nakayama, Osamu, Yamaguchi, Shungo, Hikoso, Kazunori, Kashiwase, Toshihiro, Takeda, Tetsuya, Watanabe, Toshiaki, Mano, Yasushi, Matsumura, Hikaru, Ueno, Masatsugu, Hori   +13 more
openaire   +2 more sources

MIIP remodels Rac1-mediated cytoskeleton structure in suppression of endometrial cancer metastasis

Journal of Hematology & Oncology, 2016
Background Endometrial carcinoma (EC) is one of the most common malignancies of the female reproductive system. Migration and invasion inhibitory protein (MIIP) gene was recently discovered candidate tumor suppress gene which located at chromosome 1p36 ...
Yingmei Wang, Limei Hu, Ping Ji, Fei Teng, Wenyan Tian, Yuexin Liu, David Cogdell, Jinsong Liu, Anil K. Sood, Russell Broaddus, Fengxia Xue, Wei Zhang   +11 more
doaj   +1 more source

Carboxyl-terminal isoprenylation of ras-related GTP-binding proteins encoded by rac1, rac2, and ralA

Journal of Biological Chemistry, 1991
Membrane localization of p21ras is dependent upon its posttranslational modification by a 15-carbon farnesyl group. The isoprenoid is linked to a cysteine located within a conserved carboxyl-terminal sequence termed the "CAAX" box (where C is cysteine, A is an aliphatic amino acid, and X is any amino acid).
B T, Kinsella, R A, Erdman, W A, Maltese
openaire   +2 more sources

SmgGDS stabilizes nucleotide-bound and -free forms of the Rac1 GTP-binding protein and stimulates GTP/GDP exchange through a substituted enzyme mechanism [PDF]

Biochemical Journal, 1994
The Rac proteins, Rac1 and Rac2, are essential components of the NADPH oxidase system of phagocytes and regulate the actin assembly associated with membrane ruffling. These functions are controlled by the GTP-bound form of Rac. The biochemical interaction between Rac and its only known GDP-dissociation stimulator (termed smgGDS) was characterized ...
T H, Chuang, X, Xu, L A, Quilliam, G M, Bokoch   +3 more
openaire   +2 more sources

RNA-Binding Protein HuR Regulates Rac1 Nucleocytoplasmic Shuttling Through Nucleophosmin in the Intestinal EpitheliumSummary

Cellular and Molecular Gastroenterology and Hepatology, 2019
Background & Aims: The mammalian intestinal epithelium is a rapidly self-renewing tissue in the body, and its homeostasis is tightly regulated via well-controlled mechanisms.
Lan Liu, Lan Xiao, Hee K. Chung, Min S. Kwon, Xiao-Xue Li, Na Wu, Jaladanki N. Rao, Jian-Ying Wang   +7 more
doaj   +1 more source

Phosphorylation and Activation of RhoA by ERK in Response to Epidermal Growth Factor Stimulation. [PDF]

PLoS ONE, 2016
The small GTPase RhoA has been implicated in various cellular activities, including the formation of stress fibers, cell motility, and cytokinesis. In addition to the canonical GTPase cycle, recent findings have suggested that phosphorylation further ...
Junfeng Tong, Laiji Li, Barbara Ballermann, Zhixiang Wang   +3 more
doaj   +1 more source

The small GTP-binding proteins Rac1 and Cdc42regulate the activity of the JNK/SAPK signaling pathway

Cell, 1995
c-Jun amino-terminal kinases (JNKs) and mitogen-activated protein kinases (MAPKs) are closely related; however, they are independently regulated by a variety of environmental stimuli. Although molecules linking growth factor receptors to MAPKs have been recently identified, little is known about pathways controlling JNK activation.
Coso OA, Chiariello M, Yu, JC, Teramoto H, Crespo P, Xu N, Miki T, Gutkind JS   +8 more
openaire   +4 more sources

The GTPase ARF6 Controls ROS Production to Mediate Angiotensin II-Induced Vascular Smooth Muscle Cell Proliferation. [PDF]

PLoS ONE, 2016
High reactive oxygen species (ROS) levels and enhanced vascular smooth muscle cells (VSMC) proliferation are observed in numerous cardiovascular diseases.
Mohamed Bourmoum, Ricardo Charles, Audrey Claing   +2 more
doaj   +1 more source