Results 31 to 40 of about 22,107 (146)

Identification of the ral and rac1 Gene Products, Low Molecular Mass GTP-binding Proteins from Human Platelets

Journal of Biological Chemistry, 1989
Identification of the GTP-binding proteins from human platelet particulate fractions was attained by their purification via successive column chromatography steps followed by amino acid sequencing. To enhance the likelihood of identifying the GTP-binding proteins, two assays were employed to monitor GTP-binding activities: (i) guanosine 5'-(3-O-[35S ...
P G, Polakis, R F, Weber, B, Nevins, J R, Didsbury, T, Evans, R, Snyderman   +5 more
openaire   +2 more sources

Vav Proteins in Development of the Brain: A Potential Relationship to the Pathogenesis of Congenital Zika Syndrome?

Viruses, 2022
Zika virus (ZIKV) infection during pregnancy can result in a significant impact on the brain and eye of the developing fetus, termed congenital zika syndrome (CZS).
Aidan J. Norbury, Lachlan A. Jolly, Luke P. Kris, Jillian M. Carr   +3 more
doaj   +1 more source

Actin re-organization induced by Chlamydia trachomatis serovar D--evidence for a critical role of the effector protein CT166 targeting Rac. [PDF]

PLoS ONE, 2010
The intracellular bacterium Chlamydia trachomatis causes infections of urogenital tract, eyes or lungs. Alignment reveals homology of CT166, a putative effector protein of urogenital C. trachomatis serovars, with the N-terminal glucosyltransferase domain
Jessica Thalmann, Katrin Janik, Martin May, Kirsten Sommer, Jenny Ebeling, Fred Hofmann, Harald Genth, Andreas Klos   +7 more
doaj   +1 more source

Rac1 signaling in the establishment of the fucoid algal body plan

Frontiers in Plant Science, 2014
Fucoid zygotes use environmental vectors, including sunlight, to initiate a growth axis a few hours after fertilization. The first division is then transversely oriented by the growth axis, producing daughter cells of distinct fates.
Whitney E Hable
doaj   +1 more source

Posttranslational modification of the RHO of plants protein RACB by phosphorylation and cross-kingdom conserved ubiquitination.

PLoS ONE, 2022
Small RHO-type G-proteins act as signaling hubs and master regulators of polarity in eukaryotic cells. Their activity is tightly controlled, as defective RHO signaling leads to aberrant growth and developmental defects.
Lukas Weiß, Lana Gaelings, Tina Reiner, Julia Mergner, Bernhard Kuster, Attila Fehér, Götz Hensel, Manfred Gahrtz, Jochen Kumlehn, Stefan Engelhardt, Ralph Hückelhoven   +10 more
doaj   +1 more source

RCC2 over-expression in tumor cells alters apoptosis and drug sensitivity by regulating Rac1 activation

BMC Cancer, 2018
Background Small GTP binding protein Rac1 is a component of NADPH oxidases and is essential for superoxide-induced cell death. Rac1 is activated by guanine nucleotide exchange factors (GEFs), and this activation can be blocked by regulator of chromosome ...
Nan Wu, Dong Ren, Su Li, Wenli Ma, Shaoyan Hu, Yan Jin, Sheng Xiao   +6 more
doaj   +1 more source

Estrogen Decreases Cytoskeletal Organization by Forming an ERα/SHP2/c-Src Complex in Osteoclasts to Protect against Ovariectomy-Induced Bone Loss in Mice

Antioxidants, 2021
Loss of ovarian function is closely related to estrogen (E2) deficiency, which is responsible for increased osteoclast (OC) differentiation and activity.
Hyun-Jung Park, Malihatosadat Gholam-Zadeh, Sun-Young Yoon, Jae-Hee Suh, Hye-Seon Choi   +4 more
doaj   +1 more source

Mechanism of low molecular weight GTP binding protein RAC1 in injury of neural function of rats with cerebral ischemia reperfusion

Asian Pacific Journal of Tropical Medicine, 2016
To discuss the mechanism of low molecular weight GTP binding protein RAC1 in the injury of neural function based on building the rat model of cerebral ischemia reperfusion.Middle cerebral artery of rats was ligated and the ligature was released to restore the perfusion after 2 h, the rat model of cerebral ischemia reperfusion injury was built, while ...
Li, Ya-Hong, Qiao, Lu-Jun, Lin, Xiao-Ying   +2 more
openaire   +2 more sources

Cloning and Expression Pattern of rnd1 and Its Involvement in Disease Resistance in Japanese Flounder (Paralichthys olivaceus)

Progress in Fishery Sciences, 2023
Edwardsiella tarda is a major causative pathogen of bacterial ascites in Japanese flounder, leading to massive economic losses, and the discovery of molecular markers linked to disease resistance is an effective strategy in resistance breeding programs ...
Ziwei ZHANG, Lei WANG, Kaimin LI, Sheng LU, Weiwei ZHENG, Songlin CHEN   +5 more
doaj   +1 more source

Deletion of Rac1GTPase in the Myeloid Lineage Protects against Inflammation-Mediated Kidney Injury in Mice.

PLoS ONE, 2016
Macrophage-mediated inflammation has been implicated in various kidney diseases. We previously reported that Rac1, a Rho family small GTP-binding protein, was overactivated in several chronic kidney disease models, and that Rac1 inhibitors ameliorated ...
Miki Nagase, Hidetake Kurihara, Atsu Aiba, Morag J Young, Tatsuo Sakai   +4 more
doaj   +1 more source