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In-vivo inhibition of neutral endopeptidase 1 results in higher absorbed tumor doses of [177Lu]Lu-PP-F11N in humans: the lumed phase 0b study. [PDF]

open access: yesEJNMMI Res
Rottenburger C   +13 more
europepmc   +1 more source
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Racecadotril

Drugs, 2000
Racecadotril is an oral enkephalinase inhibitor used in the treatment of acute diarrhoea. It prevents the degradation of endogenous opioids (enkephalins), thereby reducing hypersecretion of water and electrolytes into the intestinal lumen. In a randomised double-blind study in 6 adult volunteers with castor oil-induced diarrhoea, racecadotril ...
Anna J. Matheson, Stuart Noble
  +8 more sources

Hypersensitivity to racecadotril: a case report

European Journal of Pediatrics, 2006
Hypersensitivity to racecadotril: a case ...
Nucera, Eleonora   +5 more
openaire   +4 more sources

REVIEW: Racecadotril Versus Loperamide: Antidiarrheal Research Revisited

Digestive Diseases and Sciences, 2003
Racecadotril is an enkephalinase inhibitor, presented as a purely antisecretory agent with advantages over the opiate-receptor agonist loperamide in the treatment of diarrhea. A critical review of the literature and the models used was performed. Although pretreatment with high doses of racecadotril reduced cholera toxin-induced secretion and although ...
F. Awouters   +2 more
openaire   +3 more sources

Racecadotril demonstrates intestinal antisecretory activity in vivo

Alimentary Pharmacology & Therapeutics, 1999
Background Racecadotril (acetorphan), a potent enkephalinase inhibitor, protects endogenous enkephalins from degradation. Racecadotril exhibits experimental and clinical antidiarrhoeal activity without any effect on intestinal motility, suggesting selective antisecretory activity.
Primi, M.P.   +4 more
openaire   +4 more sources

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