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Clinical Characteristics, Treatment, and Outcomes in Children with Benign Convulsions with Mild Gastroenteritis in the Philippine General Hospital: A Retrospective Cohort Study. [PDF]
Acta Med PhilippSantos KTD +2 more
europepmc +1 more source
Hypersensitivity to racecadotril: a case report
European Journal of Pediatrics, 2006 Hypersensitivity to racecadotril: a case ...
Nucera, Eleonora +5 more
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An overview of clinical studies with racecadotril in adults
International Journal of Antimicrobial Agents, 2000Since preclinical studies had indicated the potential efficacy and tolerability of racecadotril for the treatment of diarrhoea in man, a series of studies was carried out to assess the clinical effects of racecadotril. These studies were also designed to evaluate whether racecadotril possessed the clinical properties that had been previously identified
J M Lecomte, J M Lecomte
exaly +3 more sources
Racecadotril: a new approach to the treatment of diarrhoea
International Journal of Antimicrobial Agents, 2000Since enkephalins were discovered in 1975, it has become clear that they play an antisecretory role in the gastrointestinal tract. Hence a rational research programme was directed at the development of a drug that would preserve these neurotransmitter peptides in the gut by preventing their inactivation.
J C Schwartz, J -C Schwartz
exaly +3 more sources
Drugs, 2000
Racecadotril is an oral enkephalinase inhibitor used in the treatment of acute diarrhoea. It prevents the degradation of endogenous opioids (enkephalins), thereby reducing hypersecretion of water and electrolytes into the intestinal lumen. In a randomised double-blind study in 6 adult volunteers with castor oil-induced diarrhoea, racecadotril ...
A J, Matheson, S, Noble
+5 more sources
Racecadotril is an oral enkephalinase inhibitor used in the treatment of acute diarrhoea. It prevents the degradation of endogenous opioids (enkephalins), thereby reducing hypersecretion of water and electrolytes into the intestinal lumen. In a randomised double-blind study in 6 adult volunteers with castor oil-induced diarrhoea, racecadotril ...
A J, Matheson, S, Noble
+5 more sources
Racecadotril in the Treatment of Acute Diarrhoea in Adults. An Individual Patient Data Based Meta-Analysis () [PDF]
International Journal of Clinical Medicine, 2014 Racecadotril is an antidiarrhoeal drug with a pure intestinal antisecretory mechanism of action. Aim: To assess racecadotril efficacy, whatever its dose, versus placebo in adult acute diarrhoea.
Hamza, Habib +3 more
exaly +2 more sources
Drug and Therapeutics Bulletin, 2013
Worldwide, there are about two billion cases of diarrhoeal disease every year and it is the second leading cause of death in children under 5 years of age, killing 1.5 million children annually.1 The most severe threat posed by diarrhoea is dehydration.
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Worldwide, there are about two billion cases of diarrhoeal disease every year and it is the second leading cause of death in children under 5 years of age, killing 1.5 million children annually.1 The most severe threat posed by diarrhoea is dehydration.
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Efficacy and tolerability of racecadotril in acute diarrhea in children
Gastroenterology, 2001Oral rehydration therapy is the only treatment recommended by the World Health Organization in acute diarrhea in children. Antisecretory drugs available could not be used because of their side effects, except for racecadotril, which is efficient in acute diarrhea in adults.The efficacy and tolerability of racecadotril (1.5 mg/kg administered orally 3 ...
J P, Cézard +16 more
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