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Racecadotril : A Novel Antidiarrheal [PDF]
Medical Journal Armed Forces India, 2008 N, Singh, S, Narayan
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Racecadotril: a new approach to the treatment of diarrhoea
International Journal of Antimicrobial Agents, 2000Since enkephalins were discovered in 1975, it has become clear that they play an antisecretory role in the gastrointestinal tract. Hence a rational research programme was directed at the development of a drug that would preserve these neurotransmitter peptides in the gut by preventing their inactivation.
J C Schwartz
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Hypersensitivity to racecadotril: a case report
European Journal of Pediatrics, 2006Hypersensitivity to racecadotril: a case ...
Nucera, Eleonora +5 more
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Racecadotril in the Treatment of Acute Watery Diarrhea in Children
New England Journal of Medicine, 2000Racecadotril (acetorphan), an enkephalinase inhibitor with antisecretory and antidiarrheal actions, is an effective and safe treatment for acute diarrhea in adults and children. Whether treatment with racecadotril and oral rehydration therapy is more effective than treatment with oral rehydration alone in hospitalized children with acute watery ...
Eduardo Salazar-Lindo
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Efficacy and tolerability of racecadotril in acute diarrhea in children
Gastroenterology, 2001Oral rehydration therapy is the only treatment recommended by the World Health Organization in acute diarrhea in children. Antisecretory drugs available could not be used because of their side effects, except for racecadotril, which is efficient in acute diarrhea in adults.The efficacy and tolerability of racecadotril (1.5 mg/kg administered orally 3 ...
J P, Cézard +16 more
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Comparison of racecadotril and loperamide in adults with acute diarrhoea
Alimentary Pharmacology & Therapeutics, 1999MethodsA multicentre, randomized, double‐blind, double‐placebo, parallel‐group study was carried out to compare the efficacy, tolerability, and safety of racecadotril (100 mg three times daily) and loperamide (2 mg after each diarrhoeic stool) in 157 adults with acute diarrhoea.
J M, Vetel +3 more
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Drug and Therapeutics Bulletin, 2013
Worldwide, there are about two billion cases of diarrhoeal disease every year and it is the second leading cause of death in children under 5 years of age, killing 1.5 million children annually.1 The most severe threat posed by diarrhoea is dehydration.
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Worldwide, there are about two billion cases of diarrhoeal disease every year and it is the second leading cause of death in children under 5 years of age, killing 1.5 million children annually.1 The most severe threat posed by diarrhoea is dehydration.
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Racecadotril demonstrates intestinal antisecretory activity in vivo
Alimentary Pharmacology & Therapeutics, 1999Background Racecadotril (acetorphan), a potent enkephalinase inhibitor, protects endogenous enkephalins from degradation. Racecadotril exhibits experimental and clinical antidiarrhoeal activity without any effect on intestinal motility, suggesting selective antisecretory activity.
Primi, M.P. +4 more
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Systematic review: racecadotril in the treatment of acute diarrhoea in children
Alimentary Pharmacology & Therapeutics, 2007SummaryBackgroundRacecadotril (acetorphan) is an antisecretory drug that exerts its antidiarrhoeal effects by inhibiting intestinal enkephalinase.AimTo summarize studies testing the efficacy and safety of racecadotril for treating children with acute gastroenteritis.MethodsReports were gathered by searching electronic databases MEDLINE, EMBASE, the ...
H, Szajewska +3 more
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