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Racecadotril in Management of Infant Diarrhea
International Journal of Clinical Chemistry and Laboratory Medicine, 2016 openaire +1 more source
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An overview of clinical studies with racecadotril in adults
International Journal of Antimicrobial Agents, 2000Since preclinical studies had indicated the potential efficacy and tolerability of racecadotril for the treatment of diarrhoea in man, a series of studies was carried out to assess the clinical effects of racecadotril. These studies were also designed to evaluate whether racecadotril possessed the clinical properties that had been previously identified
exaly +3 more sources
Racecadotril: a new approach to the treatment of diarrhoea
International Journal of Antimicrobial Agents, 2000Since enkephalins were discovered in 1975, it has become clear that they play an antisecretory role in the gastrointestinal tract. Hence a rational research programme was directed at the development of a drug that would preserve these neurotransmitter peptides in the gut by preventing their inactivation.
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Racecadotril in the Treatment of Acute Watery Diarrhea in Children
New England Journal of Medicine, 2000Racecadotril (acetorphan), an enkephalinase inhibitor with antisecretory and antidiarrheal actions, is an effective and safe treatment for acute diarrhea in adults and children. Whether treatment with racecadotril and oral rehydration therapy is more effective than treatment with oral rehydration alone in hospitalized children with acute watery ...
E, Salazar-Lindo +3 more
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Drugs, 2000
Racecadotril is an oral enkephalinase inhibitor used in the treatment of acute diarrhoea. It prevents the degradation of endogenous opioids (enkephalins), thereby reducing hypersecretion of water and electrolytes into the intestinal lumen. In a randomised double-blind study in 6 adult volunteers with castor oil-induced diarrhoea, racecadotril ...
A J, Matheson, S, Noble
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Racecadotril is an oral enkephalinase inhibitor used in the treatment of acute diarrhoea. It prevents the degradation of endogenous opioids (enkephalins), thereby reducing hypersecretion of water and electrolytes into the intestinal lumen. In a randomised double-blind study in 6 adult volunteers with castor oil-induced diarrhoea, racecadotril ...
A J, Matheson, S, Noble
+5 more sources
Hypersensitivity to racecadotril: a case report
European Journal of Pediatrics, 2006Hypersensitivity to racecadotril: a case ...
Nucera, Eleonora +5 more
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Racecadotril demonstrates intestinal antisecretory activity in vivo
Alimentary Pharmacology & Therapeutics, 1999Background Racecadotril (acetorphan), a potent enkephalinase inhibitor, protects endogenous enkephalins from degradation. Racecadotril exhibits experimental and clinical antidiarrhoeal activity without any effect on intestinal motility, suggesting selective antisecretory activity.
Primi, M.P. +4 more
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Racecadotril versus loperamide: antidiarrheal research revisited.
Digestive diseases and sciences, 2003Racecadotril is an enkephalinase inhibitor, presented as a purely antisecretory agent with advantages over the opiate-receptor agonist loperamide in the treatment of diarrhea. A critical review of the literature and the models used was performed. Although pretreatment with high doses of racecadotril reduced cholera toxin-induced secretion and although ...
S, Huighebaert +2 more
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Drug and Therapeutics Bulletin, 2013
Worldwide, there are about two billion cases of diarrhoeal disease every year and it is the second leading cause of death in children under 5 years of age, killing 1.5 million children annually.1 The most severe threat posed by diarrhoea is dehydration.
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Worldwide, there are about two billion cases of diarrhoeal disease every year and it is the second leading cause of death in children under 5 years of age, killing 1.5 million children annually.1 The most severe threat posed by diarrhoea is dehydration.
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Comparison of racecadotril and loperamide in adults with acute diarrhoea
Alimentary Pharmacology & Therapeutics, 1999MethodsA multicentre, randomized, double‐blind, double‐placebo, parallel‐group study was carried out to compare the efficacy, tolerability, and safety of racecadotril (100 mg three times daily) and loperamide (2 mg after each diarrhoeic stool) in 157 adults with acute diarrhoea.
J M, Vetel +3 more
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