Results 1 to 10 of about 1,034 (134)

Alpha Ketoglutarate Downregulates the Neutral Endopeptidase and Enhances the Growth Inhibitory Activity of Thiorphan in Highly Aggressive Osteosarcoma Cells [PDF]

Molecules, 2022
Since natural substances are widely explored as epigenetic modulators of gene expression and epigenetic abnormalities are important causes of cancerogenesis, factors with pro-tumor activities subjected to epigenetic control, e.g., neutral endopeptidase ...
Magdalena Mizerska-Kowalska, Adrianna Sławińska-Brych, Emilia Niedziela, Viktor Brodovskiy, Barbara Zdzisińska   +4 more
doaj   +2 more sources

Integrating metabolomics, bionics, and culturomics to study probiotics-driven drug metabolism [PDF]

Frontiers in Pharmacology, 2023
Many drugs have been shown to be metabolized by the human gut microbiome, but probiotic-driven drug-metabolizing capacity is rarely explored. Here, we developed an integrated metabolomics, culturomics, and bionics framework for systematically studying ...
Bohai Li, Bohai Li, Bohai Li, Lai-Yu Kwok, Lai-Yu Kwok, Lai-Yu Kwok, Dandan Wang, Dandan Wang, Dandan Wang, Lu Li, Lu Li, Lu Li, Shuai Guo, Shuai Guo, Shuai Guo, Yongfu Chen, Yongfu Chen, Yongfu Chen   +17 more
doaj   +2 more sources

CRISPR/Cas9-engineering of Kell null erythrocytes to unveil host targeted irresistible antimalarial [PDF]

Communications Biology
Malaria elimination faces challenges from drug resistance, stemming from mutations within the parasite’s genetic makeup. Genetic adaptations in key erythrocyte proteins offer malaria protection in endemic regions.
Geeta Kumari, Pragya Gupta, Sangam G. Goswami, Ravi Jain, Sakshi Anand, Shreeja Biswas, Swati Garg, Priya Thakur, Vinodh Saravanakumar, V. R. Arvinden, Bidhan Goswami, Ipsita Pal Bhowmick, Narla Mohandas, Jeremy Burrows, Sivaprakash Ramalingam, Shailja Singh   +15 more
doaj   +2 more sources

Exploiting the angiotensin-converting enzyme pathway to augment endogenous opioid signaling [PDF]

Communications Biology
Angiotensin Converting Enzyme (ACE) impacts hemodynamics by regulating the conversion of angiotensin I to the vasoconstricting angiotensin II. We recently identified a non-canonical central role of ACE in the degradation of enkephalin heptapeptide, Met ...
Prakashkumar Dobariya, Jessica Williams, Filip Hanak, Patrick E. Rothwell, Swati S. More   +4 more
doaj   +2 more sources

Synthesis and Biological Evaluation of Hydroxylated Monocarbonyl Curcumin Derivatives as Potential Inducers of Neprilysin Activity [PDF]

Biomedicines, 2021
Background: Alzheimer’s disease (AD) involves impairment of Aβ clearance. Neprilysin (NEP) is the most efficient Aβ peptidase. Enhancement of the activity or expression of NEP may provide a prominent therapeutic strategy against AD.
Dimitris Matiadis, See-Ting Ng, Eric H.-L. Chen, Georgia Nigianni, Veroniki P. Vidali, Aleksander Canko, Rita P.-Y. Chen, Marina Sagnou   +7 more
doaj   +2 more sources

Structures of soluble rabbit neprilysin complexed with phosphoramidon or thiorphan [PDF]

Acta Crystallographica Section F, Structural Biology Communications, 2019
Neutral endopeptidase (neprilysin; NEP) is a proteinase that cleaves a wide variety of peptides and has been implicated in Alzheimer's disease, cardiovascular conditions, arthritis and other inflammatory diseases. The structure of the soluble extracellular domain (residues 55–750) of rabbit neprilysin was solved both in its native form at 2.1 Å ...
Jürgen Sygusch, Pawel Grochulski, Grochulski P   +2 more
exaly   +3 more sources

Integrated network pharmacology and bioinformatics analysis reveals MME as key target of Notoginsenoside R1 in diabetic nephropathy [PDF]

BMC Complementary Medicine and Therapies
Background Diabetic nephropathy (DN) is a major diabetes complication and a primary cause of end-stage renal failure. Notoginsenoside R1 (NGR1) is known to reduce proteinuria, exert hypoglycemic effects, and enhance renal function in DN patients. However,
Xinyu Gan, Mingzhu Liang, Halinuer Shadekejiang, Huan Hong, Jinyu Lu, Xu Li, Xueqin Zhang, Chen Lu   +7 more
doaj   +2 more sources

Significance of CD10 for Mucosal Immunomodulation by β-Casomorphin-7 in Exacerbation of Ulcerative Colitis [PDF]

Current Issues in Molecular Biology
β-Casomorphin-7 (BCM), a breakdown product of milk β-casein, exhibits opioid activity. Opioids are known to affect the immune system, but the effects of BCM on ulcerative colitis (UC) are not clear.
Yoshihiro Miyagawa, Rina Fujiwara-Tani, Ayaka Ikemoto, Rika Sasaki, Ruiko Ogata, Yukiko Nishiguchi, Kei Goto, Isao Kawahara, Takamitsu Sasaki, Hiroki Kuniyasu   +9 more
doaj   +2 more sources

Thiorphan reprograms neurons to promote functional recovery after spinal cord injury. [PDF]

Nature
Abstract We previously identified an embryonic shift in the corticospinal motor neuronal transcriptome after spinal cord injury associated with successful axonal regeneration 1 .
van Niekerk EA, de Freria CM, Mancarci BO, Groeniger K, Kulinich D, Riley T, Kawaguchi R, Okawa S, Vokes T, Rosenzweig ES, Sinopoulou E, Castle MJ, Huie R, Ferguson AR, Kfoury-Beaumont N, Khalessi A, Pavlidis P, Tuszynski MH.   +17 more
europepmc   +3 more sources

Design, synthesis, and evaluation of novel racecadotril-tetrazole-amino acid derivatives as new potent analgesic agents

Research in Pharmaceutical Sciences, 2021
Background and purpose: Although pain is one of the most common symptoms of diseases, it is often mismanaged due to limited access to painkillers and ineffectiveness, unacceptable side effects, or the possibility of abuse.
Mehdi Asadi, Maryam Mohammadi-Khanaposhtani, Faezeh Sadat Hosseini, Mahdi Gholami, Ahmad Reza Dehpour, Massoud Amanlou   +5 more
doaj   +1 more source