FEBS Letters, Volume 598, Issue 13, Page 1576-1590, July 2024.This study aimed to elucidate the impact of glutathione depletion on aging and neurodegeneration in Alzheimer's pathology (amyloid and tau pathologies). We demonstrated that glutathione reduction, mediated by glutamate‐cysteine ligase catalytic subunit (GCLC) deficiency, elevated Aβ42/40 levels and facilitated tau polymerization through disulfide‐bond ...
Khairun Nisa Binti Hashim +6 more
wiley +1 more source
Food Frontiers, Volume 5, Issue 2, Page 708-721, March 2024.Defatted rice bran total dietary fiber, insoluble dietary fiber, and soluble dietary fiber have notable improvement effects on obese mice. However, their potential anti‐obesity mechanisms share similarities and differences, which contributes to the advancement of personalized dietary development in the future.
Bing Zheng +8 more
wiley +1 more source
Neprilysin inhibitors and risk of Alzheimer's disease: A future perspective
Journal of Cellular and Molecular Medicine, Volume 28, Issue 2, January 2024.Abstract Alzheimer's disease (AD) is a heterogeneous neurodegenerative disease with multifaceted neuropathological disorders. AD is characterized by intracellular accumulation of phosphorylated tau proteins and extracellular deposition of amyloid beta (Aβ).
Naif H. Ali +8 more
wiley +1 more source
Telmisartan and thiorphan combination treatment attenuates fibrosis and apoptosis in preventing diabetic cardiomyopathy [PDF]
Cardiovascular Research, 2018 LCZ696, a first-generation dual angiotensin receptor-neprilysin inhibitor (ARNi), is effective in treating heart failure patients. However, the role of ARNis in treating diabetic cardiomyopathy is poorly understood. This study evaluates the efficacy of a novel combination of telmisartan [angiotensin receptor blocker (ARB)] and thiorphan [neprilysin ...
Vajir, Malek, Anil Bhanudas, Gaikwad
openaire +2 more sources
Relationship between enkephalinase inhibition of thiorphan in vivo and its analgesic activity.
Journal of Pharmacobio-Dynamics, 1985 The relationship between enkephalinase inhibition by thiorphan in vivo and analgesic activity in nociceptive tests was studied. The analgesic activity of thiorphan in various nociceptive tests was compared with that of a narcotic analgesic, morphine and antipyretic analgesic, antipyrine.
HACHISU, MITSUGU +4 more
openaire +3 more sources
Neprilysin deficiency reduces hepatic gluconeogenesis in high fat-fed mice. [PDF]
Peptides, 2023 Esser N +4 more
europepmc +1 more source
The Effects of One-Point Mutation on the New Delhi Metallo Beta-Lactamase-1 Resistance toward Carbapenem Antibiotics and β-Lactamase Inhibitors: An In Silico Systematic Approach. [PDF]
Int J Mol Sci, 2022 Tran VT +7 more
europepmc +1 more source
Opioid Withdrawal Abruptly Disrupts Amygdala Circuit Function by Reducing Peptide Actions. [PDF]
J Neurosci, 2023 Gregoriou GC +4 more
europepmc +1 more source
Aβ/Amyloid Precursor Protein-Induced Hyperexcitability and Dysregulation of Homeostatic Synaptic Plasticity in Neuron Models of Alzheimer's Disease. [PDF]
Front Aging Neurosci, 2022 Martinsson I +11 more
europepmc +1 more source