Results 41 to 50 of about 1,836 (178)

Amyloid-Beta Protein Clearance and Degradation (ABCD) Pathways and their Role in Alzheimer’s Disease [PDF]

, 2015
Amyloid-β proteins (Aβ) of 42 (Aβ42) and 40 aa (Aβ40) accumulate as senile plaques (SP) and cerebrovascular amyloid protein deposits that are defining diagnostic features of Alzheimer's disease (AD). A number of rare mutations linked to familial AD (FAD)
Baranello, Robert J., Bharani, Krishna L., Chopra, Nipun, Greig, Nigel H., Lahiri, Debomoy K., Padmaraju, Vasudevaraju, Pappolla, Miguel A., Sambamurti, Kumar   +7 more
core   +1 more source

Regulatory feedback cycle of the insulin‐degrading enzyme and the amyloid precursor protein intracellular domain: Implications for Alzheimer’s disease

Aging Cell, Volume 19, Issue 11, November 2020., 2020
AICD‐mediated regulatory feedback cycle of IDE and APP processing. Abstract One of the major pathological hallmarks of Alzheimer´s disease (AD) is an accumulation of amyloid‐β (Aβ) in brain tissue leading to formation of toxic oligomers and senile plaques.
Anna A. Lauer, Janine Mett, Daniel Janitschke, Andrea Thiel, Christoph P. Stahlmann, Cornel M. Bachmann, Felix Ritzmann, Bianca Schrul, Ulrike C. Müller, Reuven Stein, Matthias Riemenschneider, Heike S. Grimm, Tobias Hartmann, Marcus O. W. Grimm   +13 more
wiley   +1 more source

Extracellular vesicles: where the amyloid precursor protein carboxyl‐terminal fragments accumulate and amyloid‐β oligomerizes

The FASEB Journal, Volume 34, Issue 9, Page 12922-12931, September 2020., 2020
Abstract Pleiotropic roles are proposed for brain extracellular vesicles (EVs) in the development of Alzheimer's disease (AD). Our previous studies have suggested a beneficial role for EVs in AD, where the endosomal system in vulnerable neurons is compromised, contributing to the removal of accumulated material from neurons. However, the involvement of
Rocío Pérez‐González, Yohan Kim, Chelsea Miller, Javier Pacheco‐Quinto, Elizabeth A. Eckman, Efrat Levy   +5 more
wiley   +1 more source

Effect of hyperglycemia and rosiglitazone on renal and urinary neprilysin in db/db diabetic mice

Physiological Reports, Volume 8, Issue 3, February 2020., 2020
Decreased intrarenal NEP, which could have a pivotal role in the pathogenesis of diabetic kidney disease. Urinary NEP could be an index of intra‐renal NEP status. The renoprotective effects of rosiglitazone could be mediated by the up‐regulation of renal NEP expression and activity in db/db diabetic mice. Abstract Alteration in renin‐angiotensin system
Laale F. Alawi, Sana E. Emberesh, Brenda A. Owuor, Harshita Chodavarapu, Rucha Fadnavis, Salim S. El‐Amouri, Khalid M. Elased   +6 more
wiley   +1 more source

Endothelin@25 - new agonists, antagonists, inhibitors and emerging research frontiers: IUPHAR Review 12. [PDF]

, 2014
This is the final version of the article. It first appeared from Wiley via http://dx.doi.org/10.1111/bph.12874Since the discovery of endothelin (ET)-1 in 1988, the main components of the signalling pathway have become established, comprising three ...
Davenport, AP, Maguire, JJ
core   +4 more sources

Phosphorylation-deficient G-protein-biased μ-opioid receptors improve analgesia and diminish tolerance but worsen opioid side effects [PDF]

, 2019
Opioid analgesics are powerful pain relievers; however, over time, pain control diminishes as analgesic tolerance develops. The molecular mechanisms initiating tolerance have remained unresolved to date.
Bailey, A, Bateman, JT, Christie, MJ, Kliewer, A, Levitt, ES, Schmiedel, F, Schulz, S, Sianati, S, Williams, JT   +8 more
core   +2 more sources

Targets and Candidate Agents for Type 2 Diabetes Treatment with Computational Bioinformatics Approach

Journal of Diabetes Research, 2014
We sought to explore the molecular mechanism of type 2 diabetes (T2D) and identify potential drug targets and candidate agents for T2D treatment. The differentially expressed genes (DEGs) were assessed between human pancreatic islets with T2D and normal ...
Qiong Wang, Zhigang Zhao, Jing Shang, Wei Xia   +3 more
doaj   +1 more source

The use of Fluorescence Resonance Energy Transfer (FRET) peptidesfor measurement of clinically important proteolytic enzymes [PDF]

, 2009
Proteolytic enzymes have a fundamental role in many biological processes and are associated with multiple pathological conditions. Therefore, targeting these enzymes may be important for a better understanding of their function and development of ...
Carmona, Adriana Karaoglanovic, Juliano, Luiz, Juliano, Maria Aparecida   +2 more
core   +3 more sources

Thiorphan, tiopronin, and related analogs as substrates and inhibitors of peptidylglycine α‐amidating monooxygenase (PAM) [PDF]

FEBS Letters, 2005
Peptidyglycine α‐amidating monooxygenase is a copper‐ and zinc‐dependent, bifunctional enzyme that catalyzes the cleavage of glycine‐extended peptides or N‐acylglycines to the corresponding amides and glyoxylate. This reaction is a key step in the biosynthesis of bioactive α‐amidated peptides and, perhaps, the primary fatty acids amides also.
McIntyre, Neil R., Lowe, Edward W., Chew, Geoffrey H., Owen, Terrence C., Merkler, David J.   +4 more
openaire   +2 more sources

Bradykinin Release Avoids High Molecular Weight Kininogen Endocytosis [PDF]

, 2015
Human H-kininogen (120 kDa) plays a role in many pathophysiological processes and interacts with the cell surface through protein receptors and proteoglycans, which mediate H-kininogen endocytosis.
Araujo, Mariana S., Damasceno, Igor Z., Melo, Kátia Regina Brasil, Motta, Guacyara, Nader, Helena Bonciani, Nascimento, Fabio D., Sampaio, Misako Uemura, Souza, Daianne S. P., Souza, Sinval Estevam Gregorio, Tersariol, Ivarne Luis dos Santos   +9 more
core   +3 more sources