Results 41 to 50 of about 1,394 (176)

Effects of neutral endopeptidase (neprilysin) inhibition on the response to other vasoactive peptides in small human resistance arteries: studies with thiorphan and omapatrilat

, 2014
Purpose New compounds with neprilysin or neutral endopeptidase (NEP) inhibiting activity are under clinical investigation in heart failure and hypertension. We investigated the effect of NEP inhibition on the functional vasomotor responses to a range of
Dalzell, Jonathan R., Clarke, Amanda, Petrie, Mark C., Seed, Alison, Padmanabhan, Neal, Whelan, Carol J., Hillier, Christopher, McMurray, John J.V., Biggerstaff, Fiona, Berry, Colin   +9 more
core   +1 more source

Targets and Candidate Agents for Type 2 Diabetes Treatment with Computational Bioinformatics Approach

Journal of Diabetes Research, 2014
We sought to explore the molecular mechanism of type 2 diabetes (T2D) and identify potential drug targets and candidate agents for T2D treatment. The differentially expressed genes (DEGs) were assessed between human pancreatic islets with T2D and normal ...
Qiong Wang, Zhigang Zhao, Jing Shang, Wei Xia   +3 more
doaj   +1 more source

Growth promotion by oral administration of enkephalinase inhibitors (thiorphan and acetorphan) in rats and mice

, 1988
The effects of long-term oral administration of enkephalinase inhibitors (acetorphan and thiorphan) on food and water intake, live-weight gain and food conversion efficiency were investigated in growing rats and mice.
L. Buéno, P. J. M. Rivière
core   +1 more source

Effects of the neutral endopeptidase inhibitor thiorphan on cardiovascular and renal function in cirrhotic rats [PDF]

British Journal of Pharmacology, 2003
Cirrhosis is associated with cardiovascular and renal dysfunction including sodium retention. Many vasoactive peptides such as atrial natriuretic peptide (ANP) and endothelin‐1 (ET‐1) are degraded by neutral endopeptidase 24.11 (NEP). We investigated the hemodynamic and renal effects of thiorphan, a NEP inhibitor, in a rat cirrhosis model.
K S, Park, Y, Li, Y, Zhang, A L, Gerbes, H, Liu, M G, Swain, S S, Lee   +6 more
openaire   +2 more sources

Enkephalinase inhibitor potentiates substance P- and electrically induced contraction in ferret trachea

, 1987
To determine the role of endogenous enkephalinase (EC 3.4.24.11) in regulating peptide-induced contraction of airway smooth muscle, we studied the effect of the enkephalinase inhibitor, leucine-thiorphan (Leu-thiorphan), on responses of isolated ferret ...
K. Sekizawa, D. B. Borson, J. Tamaoki, J. A. Nadel   +3 more
core   +1 more source

Identifying New Drug Disease Connections for Spinal Cord Injury [PDF]

, 2020
Spinal cord injury (SCI) is a widespread and drastic condition that causes permanent paralysis below the level of the lesion, as well as a myriad of associated problems.
Riley, Theresa Marie
core   +1 more source

Acyl-CoA Binding Domain Containing 4 Polymorphism rs4986172 and Expression Can Serve as Overall Survival Biomarkers for Hepatitis B Virus-Related Hepatocellular Carcinoma Patients After Hepatectomy

Pharmacogenomics and Personalized Medicine, 2022
Huasheng Huang,* Xiwen Liao,* Guangzhi Zhu, Chuangye Han, Xiangkun Wang, Chengkun Yang, Xin Zhou, Tianyi Liang, Ketuan Huang, Tao Peng Department of Hepatobiliary Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning ...
Huang H, Liao X, Zhu G, Han C, Wang X, Yang C, Zhou X, Liang T, Huang K, Peng T   +9 more
doaj  

Orally administered prednisolone decreases plasma arginine vasopressin and serum copeptin concentrations in healthy dogs

Journal of Veterinary Internal Medicine, Volume 39, Issue 1, January/February 2025.
Abstract Background The pathophysiology of polyuria and polydipsia secondary to exogenous glucocorticoid excess is incompletely understood. Objective Investigate plasma AVP (pAVP) and serum CoP (sCoP) concentrations in healthy dogs before, during, and after abrupt discontinuation of a long‐term course of orally administered prednisolone.
Mathieu Victor Paulin, Dorsa Mehrabanpour, Suraj Unniappan, Elisabeth C. R. Snead   +3 more
wiley   +1 more source

Influence of thiorphan and phosphoramidon on the relaxant effect of vasoactive intestinal polypeptide and non-adrenergic non-cholinergic neurone stimulation in the rat gastric fundus

, 1991
Relaxations were induced in longitudinal muscle strips of the rat gastric fundus by exogenous administration of vasoactive intestinal polypeptide (VIP) and by transmural stimulation in the presence of atropine.
Smits, Geert JM, Lefebvre, Romain
core   +1 more source

Neuronal glutathione depletion elevates the Aβ42/Aβ40 ratio and tau aggregation in Alzheimer's disease mice

FEBS Letters, Volume 598, Issue 13, Page 1576-1590, July 2024.
This study aimed to elucidate the impact of glutathione depletion on aging and neurodegeneration in Alzheimer's pathology (amyloid and tau pathologies). We demonstrated that glutathione reduction, mediated by glutamate‐cysteine ligase catalytic subunit (GCLC) deficiency, elevated Aβ42/40 levels and facilitated tau polymerization through disulfide‐bond ...
Khairun Nisa Binti Hashim, Yukio Matsuba, Mika Takahashi, Naoko Kamano, Ikuo Tooyama, Takaomi C. Saido, Shoko Hashimoto   +6 more
wiley   +1 more source