Results 21 to 30 of about 1,836 (178)
Properties and modulation of excitatory inputs to the locus coeruleus
The Journal of Physiology, Volume 600, Issue 22, Page 4897-4916, 15 November 2022., 2022 Abstract figure legend Noradrenaline (NA) neurons in the locus coerueleus (LC) receive glutamatergic inputs from various regions of the brain that drive their activity. In order to characterize how these afferents differ from one another with respect to synaptic properties, an optogenetic approach was used to isolate inputs from three specific regions:
Kelsey Barcomb +3 more
wiley +1 more source
Cancer Medicine, Volume 11, Issue 11, Page 2329-2341, June 2022., 2022 A five‐gene prognostic signature associated with hypoxia and ferroptosis was identified and verified based on bioinformatics methods. Furthermore, this risk score system could stratify the immune status of patients and provide new guidance for exploring the potential mechanism of hepatocellular carcinoma development and precise treatment.
Chun‐Bo Yang +2 more
wiley +1 more source
CD10-Equipped Melanoma Cells Acquire Highly Potent Tumorigenic Activity: A Plausible Explanation of Their Significance for a Poor Prognosis. [PDF]
PLoS ONE, 2016 CD10 has been widely used in cancer diagnosis. We previously demonstrated that its expression in melanoma increased with tumor progression and predicted poor patient survival.
Junna Oba +7 more
doaj +1 more source
Contribution of proteases to the hallmarks of aging and to age‐related neurodegeneration
Aging Cell, Volume 21, Issue 5, May 2022., 2022 Proteases are a large family of proteolytic enzymes located in all cell compartments and in the extracellular space. Proteases impact all hallmarks of cellular and tissue aging, and the onset and progression of age‐related diseases including neurodegeneration.
Mamta Rai +3 more
wiley +1 more source
Structures of soluble rabbit neprilysin complexed with phosphoramidon or thiorphan [PDF]
Acta Crystallographica Section F Structural Biology Communications, 2019 Neutral endopeptidase (neprilysin; NEP) is a proteinase that cleaves a wide variety of peptides and has been implicated in Alzheimer's disease, cardiovascular conditions, arthritis and other inflammatory diseases. The structure of the soluble extracellular domain (residues 55–750) of rabbit neprilysin was solved both in its native form at 2.1 Å ...
Shaunivan L, Labiuk +2 more
openaire +2 more sources
ChemMedChem, Volume 16, Issue 22, Page 3410-3417, November 19, 2021., 2021 Thiols are potent inhibitors of metallo‐β‐lactamases, major resistance factors in Gram‐negative bacteria. Rh(II)‐based coupling procedure of dithiols to diazo building blocks was adopted for diversity‐oriented synthesis of a library of metallo‐β‐lactamase inhibitors.
Mikhail Krasavin +13 more
wiley +1 more source
Advanced Science, Volume 8, Issue 19, October 6, 2021., 2021 CD10, a transmembrane hydrolase expressed by a subset of carcinoma‐associated fibroblasts, drives tumor progression by degrading an anti‐tumoral peptide, osteogenic growth peptide (OGP). OGP impairs tumor lipid desaturation and consequently suppresses cancer stem cells (CSCs). This study sheds new light on a nexus between the niche and lipid metabolism
Shubin Yu +18 more
wiley +1 more source
Physiological Reports, Volume 9, Issue 6, March 2021., 2021 RAS blockade by a renin inhibitor (aliskiren) or neprilysin inhibition by sacubitril separately led to significant attenuation in the renal IRI‐induced renal dysfunction. The combination of aliskiren and sacubitril was more effective than either one alone. Abstract The natriuretic peptide (NP) system counter‐regulates the renin‐angiotensin system (RAS),
Fayez T. Hammad +6 more
wiley +1 more source
Disease Markers, Volume 2021, Issue 1, 2021., 2021 Objective. Dysregulation of cell cycle progression (CCP) is one of the hallmarks of cancer. Here, our study is aimed at developing a CCP‐derived gene signature for predicting high‐risk population of hepatocellular carcinoma (HCC). Methods. Our study retrospectively analyzed the transcriptome profiling and clinical information of HCC patients from The ...
Yongfeng Hui +7 more
wiley +1 more source
Impact of clinically tested NEP/ACE inhibitors on tumor uptake of [111In-DOTA]MG11 [PDF]
, 2016 Background: We have recently shown that treatment of mice with the neutral endopeptidase (NEP) inhibitor phosphoramidon (PA) improves the bioavailability and tumor uptake of biodegradable radiopeptides.
Jong, M. (Marion) de +6 more
core +5 more sources