Why dried blood spots are an ideal tool for CYP1A2 phenotyping [PDF]
, 2014 Background and Objective: Dried blood spot (DBS) sampling has gained wide interest in bioanalysis during the last decade and has already been successfully applied in pharmacokinetic and phenotyping studies.
De Kesel, Pieter +2 more
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From ARB to ARNI in Cardiovascular Control [PDF]
, 2016 Coexistence of hypertension, diabetes mellitus and chronic kidney disease synergistically aggravates the risk of cardiovascular and renal morbidity and mortality.
Danser, A.H.J. (Jan) +3 more
core +1 more source
Sex differences in the aging pattern of renin–angiotensin system serum peptidases [PDF]
, 2017 Background: Serum peptidases, such as angiotensin-converting enzyme (ACE), angiotensin-converting enzyme-2 (ACE2), neutral endopeptidase (NEP), aminopeptidase N (APN), and aminopeptidase A (APA), are important elements of the renin-angiotensin system ...
Echevarría Orella, Enrique +7 more
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Neurodegeneration-Associated Protein Fragments as Short-Lived Substrates of the N-End Rule Pathway [PDF]
, 2013 Protein aggregates are a common feature of neurodegenerative syndromes. Specific protein fragments were found to be aggregated in disorders including Alzheimer’s disease, amyotrophic lateral sclerosis, and Parkinson’s disease.
Brower, Christopher S. +2 more
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Localization of the thiorphan‐sensitive endopeptidase, termed enkephalinase A, on glial cells [PDF]
FEBS Letters, 1983 Degradation of tritiated Leu‐enkephalin was studied in cultures of primary astrocytes from rat brain. The incubation experiments with a cell suspension revealed Tyr as the main tritiated metabolite; however, Tyr—Gly—Gly and Tyr—Gly were detectable as well.
Hans, Lentzen, Palenker, Jochen
openaire +2 more sources
Opioid Facilitation of β-Adrenergic Blockade: A New Pharmacological Condition?
Pharmaceuticals, 2015 Recently, propranolol was suggested to prevent hyperlactatemia in a child with hypovolemic shock through β-adrenergic blockade. Though it is a known inhibitor of glycolysis, propranolol, outside this observation, has never been reported to fully protect ...
Joseph Vamecq +3 more
doaj +1 more source
Exposure of luminal membranes of LLC-PK1 cells to ANG II induces dimerization of AT(1)/AT(2) receptors to activate SERCA and to promote Ca2+ mobilization [PDF]
, 2012 Ferrao FM, Lara LS, Axelband F, Dias J, Carmona AK, Reis RI, Costa-Neto CM, Vieyra A, Lowe J. Exposure of luminal membranes of LLC-PK1 cells to ANG II induces dimerization of AT(1)/AT(2) receptors to activate SERCA and to promote Ca2+ mobilization.
Axelband, Flavia +8 more
core +1 more source
Thiorphan, a neutral endopeptidase inhibitor used for diarrhoea, is neuroprotective in newborn mice [PDF]
Brain, 2006 Excitotoxic damage appears to be a critical factor in the formation of perinatal brain lesions associated with cerebral palsy (CP). When injected into newborn mice, the glutamatergic analogue, ibotenate, produces cortical lesions and white matter cysts that mimic human perinatal brain lesions.
Medja, Fadia +9 more
openaire +3 more sources
Beneficial effects of combined AT1 receptor/neprilysin inhibition (ARNI) versus AT1 receptor blockade alone in the diabetic eye [PDF]
, 2016 PURPOSE. Dysfunction of the renin-angiotensin system (RAS) contributes to pathogenesis of diabetic retinopathy (DR). Yet RAS blockers have only limited beneficial effects on progression of DR in clinical trials. The natriuretic peptide system offsets RAS,
Batenburg, W.W. (Wendy) +8 more
core +5 more sources
Amyloid beta and Alzheimer’s Disease: The role of neprilysin-2 in amyloid-beta clearance
Frontiers in Aging Neuroscience, 2014 Accumulation of the amyloid-beta (Ab) peptide is a central factor in Alzheimer’s disease (AD) pathogenesis as supported by continuing evidence. This review concisely summarizes this evidence supporting a critical role for Ab in AD before discussing the ...
Robert eMarr, Daniel eHafez
doaj +1 more source