Results 31 to 40 of about 1,034 (134)

Opioid Facilitation of β-Adrenergic Blockade: A New Pharmacological Condition?

Pharmaceuticals, 2015
Recently, propranolol was suggested to prevent hyperlactatemia in a child with hypovolemic shock through β-adrenergic blockade. Though it is a known inhibitor of glycolysis, propranolol, outside this observation, has never been reported to fully protect ...
Joseph Vamecq, Karine Mention-Mulliez, Francis Leclerc, Dries Dobbelaere   +3 more
doaj   +1 more source

Amyloid beta and Alzheimer’s Disease: The role of neprilysin-2 in amyloid-beta clearance

Frontiers in Aging Neuroscience, 2014
Accumulation of the amyloid-beta (Ab) peptide is a central factor in Alzheimer’s disease (AD) pathogenesis as supported by continuing evidence. This review concisely summarizes this evidence supporting a critical role for Ab in AD before discussing the ...
Robert eMarr, Daniel eHafez
doaj   +1 more source

Regulatory feedback cycle of the insulin‐degrading enzyme and the amyloid precursor protein intracellular domain: Implications for Alzheimer’s disease

Aging Cell, Volume 19, Issue 11, November 2020., 2020
AICD‐mediated regulatory feedback cycle of IDE and APP processing. Abstract One of the major pathological hallmarks of Alzheimer´s disease (AD) is an accumulation of amyloid‐β (Aβ) in brain tissue leading to formation of toxic oligomers and senile plaques.
Anna A. Lauer, Janine Mett, Daniel Janitschke, Andrea Thiel, Christoph P. Stahlmann, Cornel M. Bachmann, Felix Ritzmann, Bianca Schrul, Ulrike C. Müller, Reuven Stein, Matthias Riemenschneider, Heike S. Grimm, Tobias Hartmann, Marcus O. W. Grimm   +13 more
wiley   +1 more source

Extracellular vesicles: where the amyloid precursor protein carboxyl‐terminal fragments accumulate and amyloid‐β oligomerizes

The FASEB Journal, Volume 34, Issue 9, Page 12922-12931, September 2020., 2020
Abstract Pleiotropic roles are proposed for brain extracellular vesicles (EVs) in the development of Alzheimer's disease (AD). Our previous studies have suggested a beneficial role for EVs in AD, where the endosomal system in vulnerable neurons is compromised, contributing to the removal of accumulated material from neurons. However, the involvement of
Rocío Pérez‐González, Yohan Kim, Chelsea Miller, Javier Pacheco‐Quinto, Elizabeth A. Eckman, Efrat Levy   +5 more
wiley   +1 more source

Effect of hyperglycemia and rosiglitazone on renal and urinary neprilysin in db/db diabetic mice

Physiological Reports, Volume 8, Issue 3, February 2020., 2020
Decreased intrarenal NEP, which could have a pivotal role in the pathogenesis of diabetic kidney disease. Urinary NEP could be an index of intra‐renal NEP status. The renoprotective effects of rosiglitazone could be mediated by the up‐regulation of renal NEP expression and activity in db/db diabetic mice. Abstract Alteration in renin‐angiotensin system
Laale F. Alawi, Sana E. Emberesh, Brenda A. Owuor, Harshita Chodavarapu, Rucha Fadnavis, Salim S. El‐Amouri, Khalid M. Elased   +6 more
wiley   +1 more source

Targets and Candidate Agents for Type 2 Diabetes Treatment with Computational Bioinformatics Approach

Journal of Diabetes Research, 2014
We sought to explore the molecular mechanism of type 2 diabetes (T2D) and identify potential drug targets and candidate agents for T2D treatment. The differentially expressed genes (DEGs) were assessed between human pancreatic islets with T2D and normal ...
Qiong Wang, Zhigang Zhao, Jing Shang, Wei Xia   +3 more
doaj   +1 more source

Thiorphan, tiopronin, and related analogs as substrates and inhibitors of peptidylglycine α‐amidating monooxygenase (PAM) [PDF]

FEBS Letters, 2005
Peptidyglycine α‐amidating monooxygenase is a copper‐ and zinc‐dependent, bifunctional enzyme that catalyzes the cleavage of glycine‐extended peptides or N‐acylglycines to the corresponding amides and glyoxylate. This reaction is a key step in the biosynthesis of bioactive α‐amidated peptides and, perhaps, the primary fatty acids amides also.
McIntyre, Neil R., Lowe, Edward W., Chew, Geoffrey H., Owen, Terrence C., Merkler, David J.   +4 more
openaire   +2 more sources

Acyl-CoA Binding Domain Containing 4 Polymorphism rs4986172 and Expression Can Serve as Overall Survival Biomarkers for Hepatitis B Virus-Related Hepatocellular Carcinoma Patients After Hepatectomy

Pharmacogenomics and Personalized Medicine, 2022
Huasheng Huang,* Xiwen Liao,* Guangzhi Zhu, Chuangye Han, Xiangkun Wang, Chengkun Yang, Xin Zhou, Tianyi Liang, Ketuan Huang, Tao Peng Department of Hepatobiliary Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning ...
Huang H, Liao X, Zhu G, Han C, Wang X, Yang C, Zhou X, Liang T, Huang K, Peng T   +9 more
doaj  

Effects of the neutral endopeptidase inhibitor thiorphan on cardiovascular and renal function in cirrhotic rats [PDF]

British Journal of Pharmacology, 2003
Cirrhosis is associated with cardiovascular and renal dysfunction including sodium retention. Many vasoactive peptides such as atrial natriuretic peptide (ANP) and endothelin‐1 (ET‐1) are degraded by neutral endopeptidase 24.11 (NEP). We investigated the hemodynamic and renal effects of thiorphan, a NEP inhibitor, in a rat cirrhosis model.
K S, Park, Y, Li, Y, Zhang, A L, Gerbes, H, Liu, M G, Swain, S S, Lee   +6 more
openaire   +2 more sources

Orally administered prednisolone decreases plasma arginine vasopressin and serum copeptin concentrations in healthy dogs

Journal of Veterinary Internal Medicine, Volume 39, Issue 1, January/February 2025.
Abstract Background The pathophysiology of polyuria and polydipsia secondary to exogenous glucocorticoid excess is incompletely understood. Objective Investigate plasma AVP (pAVP) and serum CoP (sCoP) concentrations in healthy dogs before, during, and after abrupt discontinuation of a long‐term course of orally administered prednisolone.
Mathieu Victor Paulin, Dorsa Mehrabanpour, Suraj Unniappan, Elisabeth C. R. Snead   +3 more
wiley   +1 more source