Results 31 to 40 of about 1,394 (176)
Substance P and thiorphan synergically enhance angiogenesis in wound healing [PDF]
Tissue Engineering and Regenerative Medicine, 2016 Impaired angiogenesis is a common pathological characteristic of chronic wounds. Therefore, the regulation of angiogenesis is important for proper tissue repair. It was reported that substance P (SP) accelerates wound healing in a skin injury model. SP is degraded by neutral endopeptidase (NEP).
Jihyun, Um +3 more
openaire +2 more sources
Frontiers in Pharmacology, 2012 Racecadotril, via its active metabolite thiorphan, is an inhibitor of the enzyme neutral endopeptidase (NEP, EC 3.4.24.11), thereby increasing exposure to NEP including enkephalins and atrial natriuretic peptide.
Marion eEberlin +2 more
doaj +1 more source
Localization of the thiorphan‐sensitive endopeptidase, termed enkephalinase A, on glial cells [PDF]
FEBS Letters, 1983 Degradation of tritiated Leu‐enkephalin was studied in cultures of primary astrocytes from rat brain. The incubation experiments with a cell suspension revealed Tyr as the main tritiated metabolite; however, Tyr—Gly—Gly and Tyr—Gly were detectable as well.
Hans, Lentzen, Palenker, Jochen
openaire +2 more sources
Exogenous Angiotensin I Metabolism in Aorta Isolated from Streptozotocin Treated Diabetic Rats
Journal of Diabetes Research, 2016 Purpose. Products of angiotensin (ANG) I metabolism may predispose to vascular complications of diabetes mellitus. Methods. Diabetes was induced with streptozotocin (75 mg/kg i.p.).
P. P. Wołkow +6 more
doaj +1 more source
Opioid Facilitation of β-Adrenergic Blockade: A New Pharmacological Condition?
Pharmaceuticals, 2015 Recently, propranolol was suggested to prevent hyperlactatemia in a child with hypovolemic shock through β-adrenergic blockade. Though it is a known inhibitor of glycolysis, propranolol, outside this observation, has never been reported to fully protect ...
Joseph Vamecq +3 more
doaj +1 more source
Amyloid beta and Alzheimer’s Disease: The role of neprilysin-2 in amyloid-beta clearance
Frontiers in Aging Neuroscience, 2014 Accumulation of the amyloid-beta (Ab) peptide is a central factor in Alzheimer’s disease (AD) pathogenesis as supported by continuing evidence. This review concisely summarizes this evidence supporting a critical role for Ab in AD before discussing the ...
Robert eMarr, Daniel eHafez
doaj +1 more source
Aging Cell, Volume 19, Issue 11, November 2020., 2020 AICD‐mediated regulatory feedback cycle of IDE and APP processing. Abstract One of the major pathological hallmarks of Alzheimer´s disease (AD) is an accumulation of amyloid‐β (Aβ) in brain tissue leading to formation of toxic oligomers and senile plaques.
Anna A. Lauer +13 more
wiley +1 more source
The FASEB Journal, Volume 34, Issue 9, Page 12922-12931, September 2020., 2020 Abstract Pleiotropic roles are proposed for brain extracellular vesicles (EVs) in the development of Alzheimer's disease (AD). Our previous studies have suggested a beneficial role for EVs in AD, where the endosomal system in vulnerable neurons is compromised, contributing to the removal of accumulated material from neurons. However, the involvement of
Rocío Pérez‐González +5 more
wiley +1 more source
Effect of hyperglycemia and rosiglitazone on renal and urinary neprilysin in db/db diabetic mice
Physiological Reports, Volume 8, Issue 3, February 2020., 2020 Decreased intrarenal NEP, which could have a pivotal role in the pathogenesis of diabetic kidney disease. Urinary NEP could be an index of intra‐renal NEP status. The renoprotective effects of rosiglitazone could be mediated by the up‐regulation of renal NEP expression and activity in db/db diabetic mice. Abstract Alteration in renin‐angiotensin system
Laale F. Alawi +6 more
wiley +1 more source
The effect of thiorphan on release of sensory neuropeptides from guinea-pig cerebral venous sinuses
, 1991 The effect of peptidase inhibitors on neuropeptide release from peripheral endings of capsaicin-sensitive sensory neurons was studied in cerebral superior sagittal and transverse sinuses of guinea-pig.
Geppetti, Pierangelo +5 more
core +1 more source