Results 51 to 60 of about 1,394 (176)

Exploring and comparing the anti‐obesity mechanisms of defatted rice bran total dietary fiber, insoluble dietary fiber, and soluble dietary fiber based on multi‐omics technologies

Food Frontiers, Volume 5, Issue 2, Page 708-721, March 2024.
Defatted rice bran total dietary fiber, insoluble dietary fiber, and soluble dietary fiber have notable improvement effects on obese mice. However, their potential anti‐obesity mechanisms share similarities and differences, which contributes to the advancement of personalized dietary development in the future.
Bing Zheng, Xiaole Zhao, Tianxiang Ao, Jianhua Xie, Yi Chen, Yueyao Gui, Xingcai Gao, Xiaobo Hu, Qiang Yu   +8 more
wiley   +1 more source

Role of neutral endopeptidase in exercise-induced bronchoconstriction in asthmatic subjects

, 1996
The membrane-bound metalloproteinase, neutral endopeptidase (NEP), is a degrading enzyme of both bronchoconstrictor and bronchodilator peptides within the airways.
P. J. Sterk, H. W. de Gouw, Z. Diamant, J. K. Sont, E. A. Kuijpers   +4 more
core   +1 more source

Neprilysin inhibitors and risk of Alzheimer's disease: A future perspective

Journal of Cellular and Molecular Medicine, Volume 28, Issue 2, January 2024.
Abstract Alzheimer's disease (AD) is a heterogeneous neurodegenerative disease with multifaceted neuropathological disorders. AD is characterized by intracellular accumulation of phosphorylated tau proteins and extracellular deposition of amyloid beta (Aβ).
Naif H. Ali, Hayder M. Al‐Kuraishy, Ali I. Al‐Gareeb, Saud A. Alnaaim, Athanasios Alexiou, Marios Papadakis, Asmaa A. Khalifa, Hebatallah M. Saad, Gaber El‐Saber Batiha   +8 more
wiley   +1 more source

Inhalation of substance P and thiorphan : acute toxicity and effects on respiration in conscious guinea pigs

, 1999
Substance P is a tachykinin and a biologically active neuropeptide. The peptide produces salivation, neuronal excitation, vasodilatation, increased vascular permeability and contraction of smooth muscles in the respiratory tract.
Edvinsson, Åsa A., Koch, Bo L., Koskinen, Lars-Owe D.,   +2 more
core   +1 more source

Optimum AT(1) receptor-neprilysin inhibition has superior cardioprotective effects compared with AT(1) receptor blockade alone in hypertensive rats [PDF]

, 2015
Neprilysin inhibitors prevent the breakdown of bradykinin and natriuretic peptides, promoting vasodilation and natriuresis. However, they also increase angiotensin II and endothelin-1.
Van den Berg - Garrelds, Ingrid; id_orcid, Batenburg, Wendy, Roksnoer, Lodi, Leijten, Frank, Friesema, Edith; id_orcid, Hoorn, Ewout; id_orcid, Clahsen - van Groningen, Marian; id_orcid, Danser, Jan, Bhaggoe, Usha, Poglitsch, M, Domenig, O, van Veghel, Richard, Vries, R.   +12 more
core   +1 more source

Analgesic potency of S-acetylthiorphan after intravenous administration to mice.

, 1993
As hydrolysis in serum of acetorphan to acetylthiorphan (N-[(R,S)-3-acetylmercapto-2-benzylpropanoyl]glycine) has been evidenced, both the neutral endopeptidase inhibition in vitro by acetylthiorphan and analgesic potency of acetylthiorphan after ...
Mergen, F., Poupaert, Jacques, Dumont, Pierre, Lambert, Didier   +3 more
core   +1 more source

Effect of neutral endopeptidase inhibition on the actions of adrenomedullin and endothelin-1 in resistance arteries from patients with chronic heart failure

, 2001
Adrenomedullin and endothelin are novel peptides that are produced in the blood vessel wall and have contrasting biologic actions. Both may play a pathophysiological role in atherosclerosis and chronic heart failure.
Johnston, F., Petrie, M.C., Hillier, C., McMurray, J.J.V.   +3 more
core   +1 more source

Relevância da formação de endotelina -1(1-31) na mediação do efeito nociceptivo da big endotelina-1 em camundongos: [dissertação] [PDF]

, 2008
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas. Programa de Pós-graduação em Farmacologia.The nociceptive effects of Endothelin-1 (ET) are well-known. This peptide is synthesized by cleavage of Big ET-1 by
Somensi, Amélia Regina
core  

Inhaled FMLP increases microvascular permeability in the rabbit trachea

, 1993
This study was designed to determine the effect of inhaled N-formyl- methionyl-leucyl-phenylalanine (FMLP) on microvascular permeability in the rabbit trachea and to determine if the effect could be modified by cholinergic antagonism, neutral ...
Bell, S.C., A. C. Rynell, M. J. Matheson, A. J. Finnimore, Berend, N., S. C. Bell, N. Berend, Finnimore, A.J., Rynell, A.-C., Matheson, M.J.   +9 more
core   +1 more source

Control of APN/CD13 and NEP/CD10 on sperm motility [PDF]

, 2010
Aminopeptidase N (APN/CD13) and neutral endopeptidase (NEP/CD10) are enzymes present in human sperm cells and involved in regulation of sperm motility of noncapacitated spermatozoa. We investigated the involvement of APN/CD13 and NEP/CD10 in motility and
Ekaitz Agirregoitia, Agirregoitia, Ekaitz, Nerea Subirán, Jon Irazusta, Candenas, M. Luz, Pinto Pérez, Francisco M., Francisco M. Pinto, Subiran, Nerea, Irazusta, Jon, Luz Candenas   +9 more
core   +1 more source