Neprilysin inhibitors and risk of Alzheimer's disease: A future perspective
Journal of Cellular and Molecular Medicine, Volume 28, Issue 2, January 2024.Abstract Alzheimer's disease (AD) is a heterogeneous neurodegenerative disease with multifaceted neuropathological disorders. AD is characterized by intracellular accumulation of phosphorylated tau proteins and extracellular deposition of amyloid beta (Aβ).
Naif H. Ali +8 more
wiley +1 more source
Role of endogenous endothelin-1 in the pathogenesis of gastric mucosal injury induced by local ischemia and reperfusion in rats [PDF]
, 1998 Thesis (Ph. D. in Medical Sciences)--University of Tsukuba, (A), no.
Hassan Mahmudul
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Journal of Pharmacy and Pharmacology, 2003 Abstract Relaxation induced by bradykinin is diminished by hypoxia in epicardial coronary arteries. The bradykinin-degrading enzyme, neutral endopeptidase (NEP, EC.3.4.24.11), is a potential target for coronary artery vasodilators. In this study, we examined the effect of thiorphan, an inhibitor of NEP, on the tone of porcine isolated ...
Irén, Krassói +2 more
openaire +2 more sources
Endothelin-Receptor Antagonists beyond Pulmonary Arterial Hypertension: Cancer and Fibrosis. [PDF]
, 2016 The endothelin axis and in particular the two endothelin receptors, ETA and ETB, are targets for therapeutic intervention in human diseases. Endothelin-receptor antagonists are in clinical use to treat pulmonary arterial hypertension and have been under ...
Battistini B. +13 more
core +1 more source
Neuronal pathways in tendon healing and tendinopathy : update [PDF]
, 2016 The regulatory mechanisms involved in tendon homeostasis and repair are not fully understood. Accumulating data, however, demonstrate that the nervous system, in addition to afferent (sensory) functions, through efferent neuronal pathways plays an active
Ackermann, Paul +5 more
core +1 more source
Natural Products in Organic Synthesis [PDF]
, 1996 A resume of four lectures presented by the author during a one month visit to BIOTROP in 1995. The seminars were held at the University of Indonesia at Depok, the Technical Institute in Bandung, the Bogor Agricultural Institute and at ...
BURNELL, R. H. (ROBERT)
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Effects of the neutral endopeptidase inhibitor thiorphan on cardiovascular and renal function in cirrhotic rats [PDF]
British Journal of Pharmacology, 2003 Cirrhosis is associated with cardiovascular and renal dysfunction including sodium retention. Many vasoactive peptides such as atrial natriuretic peptide (ANP) and endothelin‐1 (ET‐1) are degraded by neutral endopeptidase 24.11 (NEP). We investigated the hemodynamic and renal effects of thiorphan, a NEP inhibitor, in a rat cirrhosis model.
K S, Park +6 more
openaire +2 more sources
Brain Neprilysin Activity and Susceptibility to Transgene-Induced Alzheimer Amyloids [PDF]
, 2005 Neprilysin (NEP) is a zinc metalloproteinase that degrades enkephalins, endothelins, and the Alzheimer’s disease amyloid ß (Aß) peptides. NEP-deficient mice possess increased levels of brain Aß1-40 and Aß1-42. The objective of this study was to determine
Carter, Troy L. +4 more
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Relationship between enkephalinase inhibition of thiorphan in vivo and its analgesic activity.
Journal of Pharmacobio-Dynamics, 1985 The relationship between enkephalinase inhibition by thiorphan in vivo and analgesic activity in nociceptive tests was studied. The analgesic activity of thiorphan in various nociceptive tests was compared with that of a narcotic analgesic, morphine and antipyretic analgesic, antipyrine.
M, Hachisu +4 more
openaire +3 more sources
Neprilysin Deficiency-Dependent Impairment of Cognitive Functions in a Mouse Model of Amyloidosis [PDF]
, 2018 Alzheimer's disease, responsible for the vast majority of dementia cases in the elderly population, is caused by accumulation of toxic levels of amyloid β peptide (Aβ) in the brain.
Mohajeri, M., Wolfer, David
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