Results 61 to 70 of about 1,394 (176)
Telmisartan and thiorphan combination treatment attenuates fibrosis and apoptosis in preventing diabetic cardiomyopathy [PDF]
Cardiovascular Research, 2018 LCZ696, a first-generation dual angiotensin receptor-neprilysin inhibitor (ARNi), is effective in treating heart failure patients. However, the role of ARNis in treating diabetic cardiomyopathy is poorly understood. This study evaluates the efficacy of a novel combination of telmisartan [angiotensin receptor blocker (ARB)] and thiorphan [neprilysin ...
Vajir, Malek, Anil Bhanudas, Gaikwad
openaire +2 more sources
Degradative enzymes modulate airway responses to intravenous neurokinins A and B
, 1989 We studied the effects of the neutral endopeptidase (NEP) inhibitor thiorphan (1.7 mg/kg iv) and the angiotensin-converting enzyme (ACE) inhibitor captopril (5.7 mg/kg iv) on airway responses to rapid intravenous infusions of neurokinin A (NKA) and ...
S. A. Shore, J. M. Drazen
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Endogenous enkephalin modulation of dopamine neurons in ventral tegmental area
, 1986 Many lines of evidence support the possibility that the opioid pentapeptides Met- and Leu-enkephalin can modulate dopamine neurons in the ventral tegmental area (VTA).
R. Richardson-Carlson, P. W. Kalivas
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, 1997 The effects of the transglutaminase-synthesized polyamine derivatives of Substance P (SP) have been further characterized by their ability to contract in vitro the rat portal vein strip (RPV), a pharmacological preparation particularly rich in NK-3 ...
FILIPPELLI, Amelia +8 more
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Role of endogenous ANP in sodium excretion in rats with experimental pulmonary hypertension
, 1992 To explore the roles of endogenous atrial natriuretic peptide (ANP) in the volume regulation, we examined effects of antiserum for ANP or a neutral endopeptidase inhibitor, thiorphan, in rats with monocrotaline (MCT)-induced pulmonary hypertension.
K. Kangawa +7 more
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Neutral endopeptidase inhibitors potentiate substance P-induced contraction in gut smooth muscle
, 1989 To determine the role of endogenous neutral endopeptidase (NEP), also called enkephalinase (EC 3.4.24.11), in regulating tachykinin-induced contraction of gut smooth muscle, we studied the effects of NEP inhibitors on the contractile responses to ...
K. Sekizawa +3 more
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, 2008 Contains fulltext : 69861.pdf (Publisher’s version ) (Open Access)Neprilysin, a zinc-metalloendopeptidase, has important roles in the physiology and pathology of many diseases such as hypertension, cancer and Alzheimer's disease.
Miners, J.S. +9 more
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Relationship between enkephalinase inhibition of thiorphan in vivo and its analgesic activity.
Journal of Pharmacobio-Dynamics, 1985 The relationship between enkephalinase inhibition by thiorphan in vivo and analgesic activity in nociceptive tests was studied. The analgesic activity of thiorphan in various nociceptive tests was compared with that of a narcotic analgesic, morphine and antipyretic analgesic, antipyrine.
HACHISU, MITSUGU +4 more
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Downregulation of endothelin receptors by autocrine production of endothelin-1
, 1993 The potent vasoconstrictor endothelin-1 (ET-1) is a paracrine, but also autocrine, factor for some types of cells. The goal of our study was to evaluate whether the receptor population in cells expressing endothelin receptor subtype A (rat mesangial ...
V. Breu +5 more
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, 2000 Background: The use of cyclosporin A (CyA) is limited by its significant nephrotoxicity. Atrial natriuretic peptide (ANP) has been shown to ameliorate the reduction in glomerular filtration rate (GFR) induced by CyA, but its effect is transient.
UNWIN R. +4 more
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