Results 81 to 90 of about 1,034 (134)

Impact of the diverse cardiotonic steroids on beta-amyloid precursor protein level. [PDF]

Front Pharmacol
Petrushanko IY, Lisitskii DR, Strelkova MA, Tolstova AP, Fedulov AP, Filonov FA, Mitkevich VA, Makarov AA.   +7 more
europepmc   +1 more source

Harder than Metal: Challenging Antimicrobial Resistance with Metallo-β-lactamase Inhibitors. [PDF]

J Med Chem
De Falco A, Alfano AI, Cutarella L, Mori M, Brindisi M.   +4 more
europepmc   +1 more source

Insulin restores renal neprilysin (NEP) and attenuates the shedding of urinary NEP and KIM-1 in diabetic Akita mice. [PDF]

Front Pharmacol
Gill RK, Salem ESB, Grobe N, Elased KM.
europepmc   +1 more source

A comprehensive review of the literature on CD10: its function, clinical application, and prospects. [PDF]

Front Pharmacol
Wang S, Xiao Y, An X, Luo L, Gong K, Yu D.   +5 more
europepmc   +1 more source

Bradykinin's carbamylation as a mechanistic link to impaired wound healing in patients with kidney dysfunction. [PDF]

BMC Biol
Kaminska M, Kałucka U, Babickova J, Benedyk-Machaczka M, Skandalou E, Grant MM, Marti HP, Mydel P.   +7 more
europepmc   +1 more source

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Potentiation of [D-Ala2]enkephalinamide analgesia in rats by thiorphan

European Journal of Pharmacology, 1982
The effect of thiorphan, an inhibitor of enkephalin dipeptidyl carboxypeptidase, was tested in the rat tail-flick test. When given alone up to 100 mg/kg s.c., thiorphan had no effect. However, thiorphan (30 mg/kg, s.c.) potentiated intraventricularly administered [D-Ala2,Met5]enkephalinamide (DEAEM) and its [Leu5]-derivative, whereas it had no effect ...
R E Chipkin, Allen Barnett
exaly   +3 more sources

Study of thiorphan degradation

International Journal of Pharmaceutics, 1988
Abstract The degradation of the enkephalinase inhibitor thiorphan was studied. Liquid chromatography UV and electrochemical detections and several techniques of spectrometry showed that the degradation was oxidative and generates diastereoisomers of the corresponding disulfide.
E Postaire, P Prognon, D Pradeau
exaly   +2 more sources

Potentiation of the hypoglycemic effect of insulin by thiorphan, an enkephalinase inhibitor

European Journal of Pharmacology, 1984
Insulin administration to rats produced a dose-related hypoglycemia. When insulin and the enkephalinase (Enk'ase) inhibitor thiorphan (30 or 100 mg/kg s.c.) were co-administered, there was a potentiation of the hypoglycemic response to insulin; these doses of thiorphan alone had no significant effect on plasma glucose.
William Kreutner, R E Chipkin
exaly   +3 more sources

Potentiation of phencyclidine-induced stereotyped behaviors in rats by thiorphan and bestatin

European Journal of Pharmacology, 1986
We investigated the effects of thiorphan, a specific inhibitor of enkephalinase A and bestatin, a specific inhibitor of aminopeptidase, on the stereotyped behaviors induced by phencyclidine (PCP) in cannulated rats. The PCP-induced turning was significantly potentiated when thiorphan (50 micrograms) and bestatin (50 micrograms) were injected ...
Hiramatsu Masayuki
exaly   +3 more sources

Effects of thiorphan on the antinociceptive actions of intrathecal [D-Ala2,Met5]enkephalin

European Journal of Pharmacology, 1982
The intrathecal administration of thiorphan (dl-3-mercapto-2-benzylpropranoyl-glycine) had no effect in doses up to 70 microgram on the rat hot plate and tail flick. Administrations of these doses of thiorphan concurrently or up to 1 h prior to the intrathecal administration of [D-Ala2, Met5] enkephalin resulted in a dose dependent, leftward shift in ...
Tony Yaksh, T L Yaksh
exaly   +3 more sources