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Efficacy and tolerability of racecadotril in acute diarrhea in children
Gastroenterology, 2001Oral rehydration therapy is the only treatment recommended by the World Health Organization in acute diarrhea in children. Antisecretory drugs available could not be used because of their side effects, except for racecadotril, which is efficient in acute diarrhea in adults.The efficacy and tolerability of racecadotril (1.5 mg/kg administered orally 3 ...
Jean Pierre Cezard +16 more
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Drug and Therapeutics Bulletin, 2013
Worldwide, there are about two billion cases of diarrhoeal disease every year and it is the second leading cause of death in children under 5 years of age, killing 1.5 million children annually.1 The most severe threat posed by diarrhoea is dehydration.
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Worldwide, there are about two billion cases of diarrhoeal disease every year and it is the second leading cause of death in children under 5 years of age, killing 1.5 million children annually.1 The most severe threat posed by diarrhoea is dehydration.
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Comparison of racecadotril and loperamide in adults with acute diarrhoea
Alimentary Pharmacology & Therapeutics, 1999MethodsA multicentre, randomized, double‐blind, double‐placebo, parallel‐group study was carried out to compare the efficacy, tolerability, and safety of racecadotril (100 mg three times daily) and loperamide (2 mg after each diarrhoeic stool) in 157 adults with acute diarrhoea.
J M, Vetel +3 more
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Racecadotril: a new approach to the treatment of diarrhoea
International Journal of Antimicrobial Agents, 2000Since enkephalins were discovered in 1975, it has become clear that they play an antisecretory role in the gastrointestinal tract. Hence a rational research programme was directed at the development of a drug that would preserve these neurotransmitter peptides in the gut by preventing their inactivation.
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An overview of clinical studies with racecadotril in adults
International Journal of Antimicrobial Agents, 2000Since preclinical studies had indicated the potential efficacy and tolerability of racecadotril for the treatment of diarrhoea in man, a series of studies was carried out to assess the clinical effects of racecadotril. These studies were also designed to evaluate whether racecadotril possessed the clinical properties that had been previously identified
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Racecadotril in the Treatment of Acute Watery Diarrhea in Children
New England Journal of Medicine, 2000Racecadotril (acetorphan), an enkephalinase inhibitor with antisecretory and antidiarrheal actions, is an effective and safe treatment for acute diarrhea in adults and children. Whether treatment with racecadotril and oral rehydration therapy is more effective than treatment with oral rehydration alone in hospitalized children with acute watery ...
Elsa Chea-Woo +3 more
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Can diarrhea affect the pharmacokinetics of racecadotril in neonatal calves?
Journal of Veterinary Pharmacology and Therapeutics, 2022AbstractThis study was aimed to determine the pharmacokinetics of antisecretory‐acting racecadotril, used in the treatment of diarrhea in humans and dogs, following oral administration in both neonatal calves with healthy and neonatal calves with infectious diarrhea.
Bunyamin Tras +7 more
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Systematic review: racecadotril in the treatment of acute diarrhoea in children
Alimentary Pharmacology & Therapeutics, 2007SummaryBackgroundRacecadotril (acetorphan) is an antisecretory drug that exerts its antidiarrhoeal effects by inhibiting intestinal enkephalinase.AimTo summarize studies testing the efficacy and safety of racecadotril for treating children with acute gastroenteritis.MethodsReports were gathered by searching electronic databases MEDLINE, EMBASE, the ...
Wieczorek J +3 more
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Inhibition of Insulin Degrading Enzyme by Racecadotril in the Brain of Wistar Rats [PDF]
Hormone and Metabolic Research, 2011 Racecadotril is an enkephalinase inhibitor used to treat abdominal discomfort in the clinic. The blood-glucose lowering action of racecadotril has been observed in rats; however, the mechanisms remain obscure. 8-week-old Wistar rats were intravenously injected with racecadotril and the levels of insulin in the brain were measured.
Juei-Tang Cheng +6 more
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RP-LC Analysis and Hydrolytic Degradation Profile of Racecadotril
Chromatographia, 2008A sensitive, stability-indicating liquid-chromatographic method for analysis of racecadotril in the presence of its degradation products has been developed and validated. Efficient chromatographic separation was achieved on a C18 column with a simple isocratic mobile phase—60:40 methanol–water. Quantification was by photo-diode array (PDA) detection at
Pawan K Basniwal +3 more
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