Results 161 to 170 of about 1,478 (205)

Concurrent Analysis of Racecadotril, Ofloxacin, and Ornidazole in a Fixed‐Dose Combination by RP‐HPLC–DAD Method

Separation Science Plus
The pharmaceutical combination of Racecadotril (RAC), Ofloxacin (OFL), and Ornidazole (ORN) is a commonly prescribed treatment for diarrhea and dysentery in pediatric patients.
Shaileshkumar K. Koradia, Gopi A. Dharsandia, A. Sen, D. Sen, Ashish D Patel   +4 more
semanticscholar   +1 more source

Hypersensitivity to racecadotril: a case report

European Journal of Pediatrics, 2006
Hypersensitivity to racecadotril: a case ...
Nucera, Eleonora, Schiavino, Domenico, Altomonte, Giorgia, Buonomo, Alessandro, Sabato, Vito, Patriarca, Giampiero   +5 more
openaire   +3 more sources

Pharmacological and electrophysiological characterization of the novel Kv7 channel inhibitor racecadotril in Parkinson's disease.

Neuropharmacology
Inhibition of KCNQ-encoded voltage-gated potassium Kv7/M channel function represents an attractive therapeutic strategy for Parkinson's disease (PD). Racecadotril (acetorphan), an inhibitor of the enzyme neutral endopeptidase, has been clinically used to
Bo Yang, Hui Liu, Shifan Zhang, Biao Liu, Qi-An Sun, Wen Li, Rong Zheng, Qingzhuo Cui, Yulin Gu, Xiaoke Li, Jie Zhang, Yidong Liu, Fan Zhang   +12 more
semanticscholar   +1 more source

Can diarrhea affect the pharmacokinetics of racecadotril in neonatal calves?

Journal of Veterinary Pharmacology and Therapeutics, 2022
This study was aimed to determine the pharmacokinetics of antisecretory-acting racecadotril, used in the treatment of diarrhea in humans and dogs, following oral administration in both neonatal calves with healthy and neonatal calves with infectious ...
B. Tras, M. Ok, T. M. Parlak, M. Ider, R. Yildiz, H. Eser Faki, Z. Ozdemir Kutahya, K. Uney   +7 more
semanticscholar   +1 more source

Cimetidine and racecadotril: Unusual culprit drugs of a severe cutaneous adverse reaction

Contact Dermatitis, 2022
Allergy to cimetidine or racecadotril is rarely encountered in clinical practice. Patch tests (PT) and oral provocation tests (OPT) are both useful to detect the culprit drug(s) in cutaneous adverse drug reactions (CADR).
E. Kechichian, A. Weill, S. Ingen-Housz-Oro, H. Assier   +3 more
semanticscholar   +1 more source

Racecadotril demonstrates intestinal antisecretory activity in vivo

Alimentary Pharmacology & Therapeutics, 1999
Background Racecadotril (acetorphan), a potent enkephalinase inhibitor, protects endogenous enkephalins from degradation. Racecadotril exhibits experimental and clinical antidiarrhoeal activity without any effect on intestinal motility, suggesting selective antisecretory activity.
Primi, M.P., Bueno, Lionel, Baumer, P., Berard, H., Lecomte, J.M.   +4 more
openaire   +3 more sources

VALIDATED RP-HPLC METHOD AND STABILITY STUDIES FOR SIMULTANEOUS ESTIMATION OF OFLOXACIN AND RACECADOTRIL IN BULK AND PHARMACEUTICAL FORMULATION

Indian drugs, 2022
A simple, accurate and precise stability indicating method for simultaneous estimation of ofloxacin and racecadotril in bulk and marketed formulation was developed and validated by RP-HPLC. The chromatographic separation of this method was carried out by
Yunes M. M. Ali Alsayadi, Pooja A. Chawla   +1 more
semanticscholar   +1 more source

COMPARISON OF EFFICACY OF RACECADOTRIL VERSUS PROBIOTICS IN THE TREATMENT OF CHILDREN WITH ACUTE WATERY DIARRHOEA

Insights-Journal of Health and Rehabilitation
Background: Acute watery diarrhea remains one of the leading causes of mortality and morbidity in children under five years of age, particularly in low- and middle-income countries.
Zeeshan Ahmad, Sana Pervez, Maimoona Yunas, Nayab e Alam, Jan Mohammad, Abdur Rahman, Sajid Hussain, Madiha Gul   +7 more
semanticscholar   +1 more source

Racecadotril versus loperamide: antidiarrheal research revisited.

Digestive diseases and sciences, 2003
Racecadotril is an enkephalinase inhibitor, presented as a purely antisecretory agent with advantages over the opiate-receptor agonist loperamide in the treatment of diarrhea. A critical review of the literature and the models used was performed. Although pretreatment with high doses of racecadotril reduced cholera toxin-induced secretion and although ...
S, Huighebaert, F, Awouters, G N J, Tytgat   +2 more
openaire   +3 more sources

Efficacy of Racecadotril in Acute Watery Diarrhea in Children

RADS Journal of Pharmacy and Allied Health Sciences
Background: Acute watery diarrhea remains a leading cause of morbidity and mortality among children, especially in low-resource settings. This study aimed to evaluate the efficacy of Racecadotril, a new class of antidiarrheal medication, in treating ...
Aqsa Noreen, Fiaz Ahmed Malik, Athar Razzaq   +2 more
semanticscholar   +1 more source