A Newly Discovered Racemic Compound of Pioglitazone Hydrochloride Is More Stable than the Commercial Conglomerate. [PDF]
Cryst Growth Des, 2017 A novel racemic compound of pioglitazone hydrochloride is discovered 17 years after the FDA approval of the conglomerate. The racemic compound shows a lower dissolution rate than the conglomerate in simulated gastric fluid at room temperature and is more
Zhang C, Matzger AJ.
europepmc +4 more sources
Resolution of a Metastable Racemic Compound of Anhydrous Phencyphos by Hydrate Formation [PDF]
Crystals, 2021 The resolution of 2-hydroxy-5,5-dimethyl-4-phenyl-1,3,2-dioxaphosphorinan 2-oxide (phencyphos) was achieved by dissolution of anhydrous racemic phencyphos, a racemic compound, accompanied by simultaneous secondary nucleation of the dissolved racemate on ...
Michel Leeman, Richard M. Kellogg
doaj +4 more sources
Enabling Direct Preferential Crystallization in a Stable Racemic Compound System. [PDF]
Molecular Pharmaceutics, 2019 The preparative resolution by preferential crystallization (PC) of proxyphylline has been achieved despite the existence of a stable racemic compound. This is enabled through the careful selection of a solvent in which both the racemic compound and the ...
Lina Harfouche +5 more
semanticscholar +8 more sources
A New Method of Resolving a Racemic Compound
Nature, 1938 SINCE the introduction of Tswett's technique of chromatographic adsorption, this process has been applied successfully to the separation of many isomeric or closely related substances, including the chlorophylls and the components of natural carotene. A few attempts have also been made to employ it for the resolution of racemic compounds by use of an ...
G. Karagunis, G. Coumoulos
exaly +6 more sources
Asymmetric amplification in amino acidsublimation involving racemic compound to conglomerate conversion [PDF]
Chemical Communications, 2011 A straightforward unprecedented sublimation protocol that reveals both conversion of a racemic compound into a racemic conglomerate and subsequent enantioenrichment has been developed for the proteinogenic amino acid valine.
Pedro Cintas +2 more
exaly +4 more sources
Use of Conglomerates Mixed Crystals to Deracemize a Stable Racemic-Compound-Forming System. [PDF]
Chemistry, 2023 Deracemization extended to racemic-compound-forming systems is demonstrated. We present here the first results of an alternative for the resolution of systems that exhibit a stable racemic compound but also a closely related conglomerate-forming system ...
Clément Pinètre +6 more
semanticscholar +2 more sources
Deracemization of a Racemic Compound by Using Tailor-Made Additives. [PDF]
Chemistry – A European Journal, 2018 AbstractViedma ripening is a process that combines abrasive grinding of a slurry of crystals with solution‐phase racemization, resulting in solid‐phase deracemization. One of the major disadvantages of Viedma ripening is that the desired compound needs to crystallize as a racemic conglomerate, accounting for only 5–10 % of all chiral molecules. Herein,
A. Engwerda +5 more
semanticscholar +4 more sources
Searching for Conglomerate Cocrystals of the Racemic Compound Praziquantel [PDF]
Crystal Growth & Design, 2023 Contains fulltext : 302916.pdf (Publisher’s version ) (Open Access)
Peerapon Rapeenun +7 more
openaire +5 more sources
Application of Crystallization Inhibitors to Chiral Separations. 1. Design of Additives to Discriminate between the Racemic Compound and the Pure Enantiomer of Mandelic Acid [PDF]
, 2007 In the context of the potential use of crystallization for spontaneous separation of racemates, it is well-known that the frequent appearance of racemic solid forms (racemic compounds) is a serious obstacle.
R. Mughal, R. Davey, N. Blagden
semanticscholar +2 more sources
A new twist in eutectic composition: deracemization of a racemic compound amino acid by Viedma ripening and temperature fluctuation. [PDF]
, 2021 Viedma ripening and temperature fluctuation are processes based on solution phase racemization and dissolution-growth of racemic or scalemic conglomerates resulting in solid-phase deracemization.
José Eugenio, Ortíz, CRISTOBAL, VIEDMA
core +3 more sources