Results 41 to 50 of about 149 (122)

Structural Optimisation of a Suspension Control Arm Using a Bi-Evolutionary Bone Remodelling Inspired Algorithm and the Radial Point Interpolation Method

Applied Sciences
Today, topological structural optimisation is a valuable computational technique for designing mechanical components with optimal mass-to-stiffness ratios.
Carlos Oliveira, Ana Pais, Jorge Belinha
doaj   +1 more source

Structural Insights Into the Function of Leishmania major Adenylosuccinate Lyase

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT One of several intriguing aspects of kinetoplastid biochemistry is the complete dependence on host purines and purine recycling due to the lack of a de novo purine biosynthesis pathway. Adenylosuccinate lyase (ASL, EC 4.3.2.2) is a key enzyme in the purine synthesis pathway responsible for the conversion of adenylosuccinate into adenosine ...
Ivan R. e Silva, Monique Mantovani, Maria E. S. D. Lino, Aline O. Albuquerque, João H. M. da Silva, Ronaldo A. P. Nagem, Adriana L. Rojas, Geraldo R. Sartori, Eduardo Horjales, David Campbell, Otavio H. Thiemann   +10 more
wiley   +1 more source

Modelling Steady Convection-Dominated Phenomena by Node-Adaptive Radial Point Interpolation Meshfree Method (RPIM) with Various RBFs

Journal of Physics: Conference Series, 2020
AbstractFor numerically solving PDEs, node or grid adaptation schemes have been invented, applied, and improved mainly to improve solution accuracy while reducing the burden caused by CPU-limitation and/or users’ interference. This becomes crucial particularly for problems involving strong changes in physical phenomena.
K Chanthawara, S Kaennakham
openaire   +1 more source

Analysis of the heterogenous structural states of the hexameric ATPase PilU of the type IV pili from Vibrio cholerae

Protein Science, Volume 35, Issue 6, June 2026.
Abstract Type IV pili (T4P) mediate surface motility, host interactions, and DNA uptake through cycles of extension and retraction. While the primary retraction ATPase PilT has been extensively characterized, its homolog PilU remains less well understood despite being demonstrated as a PilT‐dependent retraction ATPase.
Yirui Guo, Shantanu Shukla, George Minasov, Nicole L. Inniss, Thomas Klose, Valerie L. Tokars, Alfonso Mondragón, Zbyszek Otwinowski, Dominika Borek, Karla J. F. Satchell   +9 more
wiley   +1 more source

Circular thin plates buckling analysis with HRPIM method [PDF]

E3S Web of Conferences
This paper aims to introduce a new approach to simulate geometrically nonlinear problems that require shape functions with higher order continuity such as the buckling analysis of circular thin and thick plates based on two theories; Classical plate ...
Baid Sokayna, Hilali Youssef, Mesmoudi Saïd, Bourihane Oussama   +3 more
doaj   +1 more source

Structural and functional specialization of Bordetella pertussis DsbA for pertussis toxin folding

Protein Science, Volume 35, Issue 1, January 2026.
Abstract Disulphide bonds (Dsbs) are essential for the folding, stability, and function of many secreted and membrane‐associated proteins in bacteria. In Gram‐negative species, these bonds are introduced by the Dsb enzyme family, with DsbA acting as the primary thiol oxidase.
Stephanie Penning, Lachlan Mitchell, Yaoqin Hong, Taylor Cunliffe, Pramod Subedi, Geqing Wang, Lilian Hor, Makrina Totsika, Jason J. Paxman, Begoña Heras   +9 more
wiley   +1 more source

The structural and biochemical impacts of monomerizing human acetylcholinesterase

Protein Science, Volume 28, Issue 6, Page 1106-1114, June 2019., 2019
Abstract Serving a critical role in neurotransmission, human acetylcholinesterase (hAChE) is the target of organophosphate nerve agents. Hence, there is an active interest in studying the mechanism of inhibition and recovery of enzymatic activity, which could lead to better countermeasures against nerve agents. As hAChE is found in different oligomeric
Stephanie M. Bester, Kaylin A. Adipietro, Vanessa L. Funk, James M. Myslinski, Nicholas D. Keul, Jonah Cheung, Paul T. Wilder, Zachary A. Wood, David J. Weber, Jude J. Height, Scott D. Pegan   +10 more
wiley   +1 more source

Transient Dynamic Analysis of Piezoelectric Solids by the Spectral Integrated Neural Networks With Large Time Steps

International Journal of Mechanical System Dynamics, Volume 5, Issue 4, Page 721-735, December 2025.
ABSTRACT This study presents a novel neural network architecture called spectral integrated neural networks (SINNs), which combines physics‐informed neural networks (PINNs) with time‐spectral integration techniques to efficiently solve two‐ and three‐dimensional dynamic piezoelectric problems.
Zijie Song, Haodong Ma, Wenzhen Qu, Yan Gu   +3 more
wiley   +1 more source

FE‐Meshfree QUAD4 Element with Modified Radial Point Interpolation Function for Structural Dynamic Analysis

Shock and Vibration, Volume 2019, Issue 1, 2019., 2019
The partition‐of‐unity method based on FE‐Meshfree QUAD4 element synthesizes the respective advantages of meshfree and finite element methods by exploiting composite shape functions to obtain high‐order global approximations. This method yields high accuracy and convergence rate without necessitating extra nodes or DOFs.
Hongjun Zhang, Guangsong Chen, Linfang Qian, Jia Ma, Marco Gherlone   +4 more
wiley   +1 more source

A global survey of intramolecular isopeptide bonds

Protein Science, Volume 34, Issue 12, December 2025.
Abstract Many proteins harbor covalent intramolecular bonds that enhance their stability and resistance to thermal, mechanical, and proteolytic insults. Intramolecular isopeptide bonds represent one such covalent interaction, yet their distribution across protein domains and organisms has been largely unexplored.
Francesco Costa, Ioannis Riziotis, Antonina Andreeva, Delhi Kalwan, Jennifer de Jong, Philip Hinchliffe, Fabio Parmeggiani, Paul R. Race, Steven G. Burston, Alex Bateman, Rob Barringer   +10 more
wiley   +1 more source