Results 61 to 70 of about 588 (163)

Structural and functional specialization of Bordetella pertussis DsbA for pertussis toxin folding

Protein Science, Volume 35, Issue 1, January 2026.
Abstract Disulphide bonds (Dsbs) are essential for the folding, stability, and function of many secreted and membrane‐associated proteins in bacteria. In Gram‐negative species, these bonds are introduced by the Dsb enzyme family, with DsbA acting as the primary thiol oxidase.
Stephanie Penning, Lachlan Mitchell, Yaoqin Hong, Taylor Cunliffe, Pramod Subedi, Geqing Wang, Lilian Hor, Makrina Totsika, Jason J. Paxman, Begoña Heras   +9 more
wiley   +1 more source

The structural and biochemical impacts of monomerizing human acetylcholinesterase

Protein Science, Volume 28, Issue 6, Page 1106-1114, June 2019., 2019
Abstract Serving a critical role in neurotransmission, human acetylcholinesterase (hAChE) is the target of organophosphate nerve agents. Hence, there is an active interest in studying the mechanism of inhibition and recovery of enzymatic activity, which could lead to better countermeasures against nerve agents. As hAChE is found in different oligomeric
Stephanie M. Bester, Kaylin A. Adipietro, Vanessa L. Funk, James M. Myslinski, Nicholas D. Keul, Jonah Cheung, Paul T. Wilder, Zachary A. Wood, David J. Weber, Jude J. Height, Scott D. Pegan   +10 more
wiley   +1 more source

Circular thin plates buckling analysis with HRPIM method [PDF]

E3S Web of Conferences
This paper aims to introduce a new approach to simulate geometrically nonlinear problems that require shape functions with higher order continuity such as the buckling analysis of circular thin and thick plates based on two theories; Classical plate ...
Baid Sokayna, Hilali Youssef, Mesmoudi Saïd, Bourihane Oussama   +3 more
doaj   +1 more source

Modelling Steady Convection-Dominated Phenomena by Node-Adaptive Radial Point Interpolation Meshfree Method (RPIM) with Various RBFs

Journal of Physics: Conference Series, 2020
AbstractFor numerically solving PDEs, node or grid adaptation schemes have been invented, applied, and improved mainly to improve solution accuracy while reducing the burden caused by CPU-limitation and/or users’ interference. This becomes crucial particularly for problems involving strong changes in physical phenomena.
K Chanthawara, S Kaennakham
openaire   +1 more source

Transient Dynamic Analysis of Piezoelectric Solids by the Spectral Integrated Neural Networks With Large Time Steps

International Journal of Mechanical System Dynamics, Volume 5, Issue 4, Page 721-735, December 2025.
ABSTRACT This study presents a novel neural network architecture called spectral integrated neural networks (SINNs), which combines physics‐informed neural networks (PINNs) with time‐spectral integration techniques to efficiently solve two‐ and three‐dimensional dynamic piezoelectric problems.
Zijie Song, Haodong Ma, Wenzhen Qu, Yan Gu   +3 more
wiley   +1 more source

FE‐Meshfree QUAD4 Element with Modified Radial Point Interpolation Function for Structural Dynamic Analysis

Shock and Vibration, Volume 2019, Issue 1, 2019., 2019
The partition‐of‐unity method based on FE‐Meshfree QUAD4 element synthesizes the respective advantages of meshfree and finite element methods by exploiting composite shape functions to obtain high‐order global approximations. This method yields high accuracy and convergence rate without necessitating extra nodes or DOFs.
Hongjun Zhang, Guangsong Chen, Linfang Qian, Jia Ma, Marco Gherlone   +4 more
wiley   +1 more source

An extended finite element method with smooth nodal stress [PDF]

, 2013
The enrichment formulation of double-interpolation finite element method (DFEM) is developed in this paper. DFEM is first proposed by Zheng \emph{et al} (2011) and it requires two stages of interpolation to construct the trial function.
Bordas, S. P. A., Kulasegaram, S., Peng, X., Wu, S. C.   +3 more
core  

Implementation of mesh free methods for linear elasticity problems [PDF]

, 2021
LAUREA MAGISTRALEPer decenni, la modellazione e simulazione di sistemi ingegneristici ha fatto affidamento sull'utilizzo del Metodo ad Elementi Finiti (FEM), uno strumento robusto e largamente diffuso usato per risolvere problemi numerici.
Saitta, Serena
core  

A global survey of intramolecular isopeptide bonds

Protein Science, Volume 34, Issue 12, December 2025.
Abstract Many proteins harbor covalent intramolecular bonds that enhance their stability and resistance to thermal, mechanical, and proteolytic insults. Intramolecular isopeptide bonds represent one such covalent interaction, yet their distribution across protein domains and organisms has been largely unexplored.
Francesco Costa, Ioannis Riziotis, Antonina Andreeva, Delhi Kalwan, Jennifer de Jong, Philip Hinchliffe, Fabio Parmeggiani, Paul R. Race, Steven G. Burston, Alex Bateman, Rob Barringer   +10 more
wiley   +1 more source

A Gradient Stable Node‐Based Smoothed Finite Element Method for Solid Mechanics Problems

Shock and Vibration, Volume 2019, Issue 1, 2019., 2019
This paper presents a gradient stable node‐based smoothed finite element method (GS‐FEM) which resolves the temporal instability of the node‐based smoothed finite element method (NS‐FEM) while significantly improving its accuracy. In the GS‐FEM, the strain is expanded at the first order by Taylor expansion in a node‐supported domain, and the strain ...
Guangsong Chen, Linfang Qian, Jia Ma, Giuseppe Ruta   +3 more
wiley   +1 more source