Results 51 to 60 of about 288,333 (267)

Synchronous vertical fracture propagation of multi-layer radial wells for enhancing stimulated height in shale oil reservoir

Journal of Rock Mechanics and Geotechnical Engineering
The diversity of interlayers in shale oil reservoir leads to a low degree of vertical reconstruction. This paper aims to propose a method to guide the synchronous initiation of hydraulic fractures in different layers by drilling multi-layer radial wells ...
Mingzhe Gu, Mao Sheng, Lejia Ren, Bo Zhang, Liuke Huang, Gensheng Li   +5 more
doaj   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Successful transradial intervention via a radial recurrent artery branch from the radioulnar alpha loop using a sheathless guiding catheter [PDF]

Yeungnam University Journal of Medicine, 2018
The radial artery is generally the preferred access route in coronary angiography and coronary intervention. However, small size, spasm, and anatomical variations concerning the radial artery are major limitations of transradial coronary intervention ...
Shin-Eui Yoon, Sangwook Park, Sung Gyun Ahn   +2 more
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Experimental Study of Different Radial Jet Drilling Parameters and Operation Regimes for Effective Well Stimulation

Applied Sciences
Radial waterjet drilling technology presents a modern solution to enhance oil recovery. This technology has already established itself at a number of oilfields, but selecting the best operational and technical parameters for radial waterjet drilling ...
Sergey Krivoshchekov, Alexander Kochnev, Evgeny Ozhgibesov, Alexey Yuzhakov   +3 more
doaj   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Modelling of multi-lateral well geometries for geothermal applications [PDF]

Advances in Geosciences, 2018
Well inflow modelling in different numerical simulation approaches are compared for a multi-lateral well. Specifically radial wells will be investigated, which can be created using Radial Jet Drilling (RJD).
E. Peters, G. Blöcher, S. Salimzadeh, P. J. P. Egberts, M. Cacace   +4 more
doaj   +1 more source

Purely magnetic tunneling between radial magnetic wells

Revista Matemática Iberoamericana
This article is devoted to the semiclassical spectral analysis of the magnetic Laplacian in two dimensions. Assuming that the magnetic field is positive and has two symmetric radial wells, we establish an accurate tunneling formula, that is a one-term estimate of the spectral gap between the lowest two eigenvalues.
Fournais, Søren, Morin, Léo, Raymond, Nicolas   +2 more
openaire   +4 more sources