Results 61 to 70 of about 4,227,716 (306)

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Charge collection narrowing mechanism in electronic-grade-diamond photodetectors

Opto-Electronic Advances
Recently, an extreme narrowband spectral response of only 8 nm in electronic-grade diamond-based photodetectors has been observed by Zheng Wei and his colleagues from Sun Yat-sen University for the first time.
Xiaoping Ouyang
doaj   +1 more source

Detection of partial-body exposure to ionizing radiation by the automatic detection of dicentrics

, 2012
International audienceIn accidental exposure to ionizing radiation, it is essential to estimate the dose received by the victims. Currently dicentric scoring is the best biological indicator of exposure.
Gregoire, Eric, Gruel, Gaëtan, Martin, Cécile, Vaurijoux, A., Gregoire, E., Roch-Lefevre, S., Vaurijoux, Aurelie, Voisin, Philippe, Roy, L., Voisin, P., Gruel, G., Voisin, Pascale, Martin, C., Roch-Lefevre, Sandrine, Roy, Laurence   +14 more
core   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

University of California Radiation Laboratory Reports UCRL-1729

, 1952
Quarterly summary report of studies conducted through the Radiation Laboratory, University of California.
Lawrence Radiation Laboratory
core  

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

Advanced porous thermoelectric materials: Design, construction, and application

Nano Research
Thermoelectric (TE) technology, capable of converting heat directly into electricity, holds great promise for applications requiring efficient energy output, such as wearable devices and aerospace vehicles.
Ruoyan Li, Bangzhi Ge, Chongjian Zhou
doaj   +1 more source

University of California Radiation Laboratory Report UCRL-769

, 1950
A quarterly summary of reports that have been published on research being conducted at the University of California Radiation ...
University of California. Radiation Laboratory.
core  

The problem of dating quartz 1 : Spectroscopic ionoluminescence of dose dependence [PDF]

, 2010
This work is partially supported by NERC studentship F008589/1.A suite of quartz samples of different provenances, irradiation, thermal and depositional histories were analysed using spectroscopic ionoluminescence (IL) to investigate variations in ...
Robinson, Ruth Alison Joyce, Hole, D E, G.E. King, R.A.J. Robinson, King, Georgina, Finch, Adrian Anthony, D.E. Hole, A.A. Finch   +7 more
core   +1 more source