Results 61 to 70 of about 436,480 (310)

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Photocarrier transport dynamics in lifetime and relaxation regimes of semiconductors containing traps

Materials Research Express, 2019
High resistivity semiconductors used in various optoelectronic devices, such as radiation detectors and photoconductive switches, usually require electrical compensation involving deep level defects, which are also closely related to the photocarrier ...
Jingyi Yu, Lingyan Xu, Binbin Zhang, Wanqi Jie   +3 more
doaj   +1 more source

Growth of Single-Crystal Cd_0.9Zn_0.1Te Ingots Using Pressure Controlled Bridgman Method

Crystals, 2020
We report growth of single-crystal Cd0.9Zn0.1Te ingots while using the pressure-controlled Bridgman method. The Cd pressure was controlled during growth to suppress its evaporation from the melt and reduce the size of Te inclusions in the as-grown ...
Fan Yang, Wanqi Jie, Miao Wang, Xiaolong Sun, Ningbo Jia, Liying Yin, Boru Zhou, Tao Wang   +7 more
doaj   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

Circulating tumor cell viability during and after radiotherapy mirrors treatment response in cancer patients

Molecular Oncology, EarlyView.
Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy, Jana Löptien, Cornelia Coith, Afroditi Nanou, Katharina Hintelmann, Pinnschmidt Hans, Cordula Petersen, Klaus Pantel, Sabine Riethdorf, Kerstin Borgmann, Harriet Wikman   +10 more
wiley   +1 more source

Design considerations for the use of laser-plasma accelerators for advanced space radiation studies

, 2012
We present design considerations for the use of laser-plasma accelerators for mimicking space radiation and testing space-grade electronics. This novel application takes advantage of the inherent ability of laser-plasma accelerators to produce particle ...
Pretzler G, Rosenzweig JB, Koenigstein, T., Hidding, B., Karger, O., Pretzler, G., Konigstein T, Rosenzweig, J. B., Hidding B, Karger O   +9 more
core   +1 more source

FSO Detection using differential signaling in outdoor correlated-channels condition [PDF]

, 2016
In this letter, we introduce a detection technique based on differential signaling scheme for outdoor free space optical communications. This method requires no channel state information (CSI) and does not suffer from the computational load compared with
Ghassemlooy, Zabih, Bhatnagar, Manav R., Zvanovec, Stanislav, Bhatnagar, Manav, Khalighi, Mohammad-Ali, Khalighi, Mohammad Ali, Mansour Abadi, Mojtaba   +6 more
core   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Detection of Gravitational Radiation [PDF]

Symposium - International Astronomical Union, 1974
The claims by J. Weber must be examined in the context of system time-response and signal-to-noise ratio. After briefly discussing the sources and spectral distribution of system noise, we discuss optimal time-domain filtering. Although five independent groups have searched for two-antenna coincidences, only Weber has claimed any excess at zero time ...
openaire   +1 more source