Results 101 to 110 of about 14,661,451 (396)

Historical Development of the Linear Nonthreshold Dose-Response Model as Applied to Radiation [PDF]

open access: yes, 2002
[Excerpt] Despite the nearly universal adoption of the linear nonthreshold dose response model (LNT) as the primary basis for radiation protection standards for the past half century, the LNT remains highly controversial and a contentious topic of ...
Kathren, Ronald L.
core   +1 more source

Structural and functional analysis of Bacillus sarcosine oxidase and its activity toward cyclic imino acids

open access: yesFEBS Open Bio, EarlyView.
Sarcosine oxidase from Bacillus sp. (SoxB) recognizes l‐proline (l‐Pro), d‐proline (d‐Pro), and l‐thioproline (l‐Tpr) as minor substrates. In this study, we measured their absorption spectra, determined the crystal structures of their enzyme complexes, and performed site‐directed mutagenesis of key residues.
Yuqi Zhang   +5 more
wiley   +1 more source

Implications of Cosmological Gamma-Ray Absorption II. Modification of gamma-ray spectra

open access: yes, 2003
Bearing on the model for the time-dependent metagalactic radiation field developed in the first paper of this series, we compute the gamma-ray attenuation due to pair production in photon-photon scattering.
Aharonian   +51 more
core   +1 more source

Interplay between RNA‐protein interactions and RNA structures in gene regulation

open access: yesFEBS Open Bio, EarlyView.
Methodological advances in mapping transcriptome‐wide RNA‐protein interactions and RNA structures have started to uncover the potential of RNP conformations in gene regulation. Competing RNA–RNA, RNA‐protein and protein–protein interactions shape the compaction and function of RNPs throughout their lifetime and may provide novel therapeutic targets in ...
Jenni Rapakko   +2 more
wiley   +1 more source

Indoleamine 2,3‐dioxygenase 1 inhibition reverses cancer‐associated fibroblast‐mediated immunosuppression in high‐grade serous ovarian cancer

open access: yesFEBS Open Bio, EarlyView.
CAF‐mediated immunosuppression in ovarian cancer is driven by IDO1, reducing T‐cell function. Inhibiting IDO1 restores T‐cell proliferation and cytotoxicity, increases cancer cell apoptosis, and may help overcome CAF‐induced immune suppression in high‐grade serous ovarian cancer. Targeting IDO1 may improve antitumor immunity.
Hyewon Lee   +3 more
wiley   +1 more source

Radiation protection at CERN

open access: yes, 2013
This paper gives a brief overview of the general principles of radiation protection legislation; explains radiological quantities and units, including some basic facts about radioactivity and the biological effects of radiation; and gives an overview of ...
Forkel-Wirth, Doris   +6 more
core   +1 more source

ATG4B is required for mTORC1‐mediated anabolic activity and is associated with clinical outcomes in non‐small cell lung cancer

open access: yesFEBS Open Bio, EarlyView.
The relationship between anabolic and catabolic processes governing lung cancer cell growth is nuanced. We show that ATG4B, an autophagy regulator, is elevated in lung cancer and that high ATG4B is associated with worse patient outcomes. Targeting ATG4B in cells reduces growth, protein synthesis, and mTORC1 activity, demonstrating a new relationship ...
Patrick J. Ryan   +6 more
wiley   +1 more source

Space radiation studies at the White Sands Missile Range Fast Burst Reactor [PDF]

open access: yes, 1972
The operation of the White Sands Missile Range Fast Burst Reactor is discussed. Space radiation studies in radiobiology, dosimetry, and transient radiation effects on electronic systems and components are described. Proposed modifications to increase the
Delapaz, A.
core   +1 more source

Probing optomechanical correlations between two optical beams down to the quantum level

open access: yes, 2008
Quantum effects of radiation pressure are expected to limit the sensitivity of second-generation gravitational-wave interferometers. Though ubiquitous, such effects are so weak that they haven't been experimentally demonstrated yet.
A. Heidmann   +6 more
core   +1 more source

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