Results 51 to 60 of about 1,295,073 (340)

TOMM20 as a driver of cancer aggressiveness via oxidative phosphorylation, maintenance of a reduced state, and resistance to apoptosis

open access: yesMolecular Oncology, EarlyView.
TOMM20 increases cancer aggressiveness by maintaining a reduced state with increased NADH and NADPH levels, oxidative phosphorylation (OXPHOS), and apoptosis resistance while reducing reactive oxygen species (ROS) levels. Conversely, CRISPR‐Cas9 knockdown of TOMM20 alters these cancer‐aggressive traits.
Ranakul Islam   +9 more
wiley   +1 more source

Radiative Regulation of Population III Star Formation [PDF]

open access: yes, 2009
We explore the impact of ultraviolet (UV) radiation from massive Population III (Pop III) stars of 25, 40, 80, and 120 M_sun on the subsequent Pop III star formation. In this paper, particular attention is paid to the dependence of radiative feedback on the mass of source Pop III star.
arxiv   +1 more source

Transcriptome‐wide analysis of circRNA and RBP profiles and their molecular relevance for GBM

open access: yesMolecular Oncology, EarlyView.
CircRNAs are differentially expressed in glioblastoma primary tumors and might serve as therapeutic targets and diagnostic markers. The investigation of circRNA and RNA‐binding proteins (RBPs) interactions shows that distinct RBPs play a role in circRNA biogenesis and function.
Julia Latowska‐Łysiak   +14 more
wiley   +1 more source

Gas stripping by radiation drag from an interstellar cloud [PDF]

open access: yes, 2004
We perform two-dimensional hydrodynamic simulation on the gas stripping by radiation drag from an interstellar cloud moving in uniform radiation fields. To properly include relativistic radiation drag, the radiation hydrodynamic equation is solved with taking into account the dilution of radiation fields by optical depth of the cloud.
arxiv   +1 more source

Radiation effects in insulators

open access: yesNuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms, 1994
AbstractMy survey of radiation effects in insulators concentrates on the three main thrusts of mechanisms, materials, and applications. By mechanisms I include the processes occurring during irradiation, including defect production, amorphisation and mixing.
openaire   +3 more sources

Elucidating prognostic significance of purine metabolism in colorectal cancer through integrating data from transcriptomic, immunohistochemical, and single‐cell RNA sequencing analysis

open access: yesMolecular Oncology, EarlyView.
Low expression of five purine metabolism‐related genes (ADSL, APRT, ADCY3, NME3, NME6) was correlated with poor survival in colorectal cancer. Immunohistochemistry analysis showed that low NME3 (early stage) and low ADSL/NME6 (late stage) levels were associated with high risk.
Sungyeon Kim   +8 more
wiley   +1 more source

Germline DNA Retention in Murine and Human Rearranged T Cell Receptor Gene Coding Joints: Alternative Recombination Signal Sequences and V(D)J Recombinase Errors

open access: yesFrontiers in Immunology, 2019
The genes coding for the antigenic T cell receptor (TR) subunits are assembled in thymocytes from discrete V, D, and J genes by a site-specific recombination process.
Justyna Mika   +4 more
doaj   +1 more source

An Enriched Environment Alters DNA Repair and Inflammatory Responses After Radiation Exposure

open access: yesFrontiers in Immunology, 2021
After the Fukushima Daiichi Nuclear Power Plant accident, there is growing concern about radiation-induced carcinogenesis. In addition, living in a long-term shelter or temporary housing due to disasters might cause unpleasant stress, which adversely ...
Sae Sakama   +11 more
doaj   +1 more source

Using ACIS on the Chandra X-ray Observatory as a particle radiation monitor [PDF]

open access: yes, 2010
The Advanced CCD Imaging Spectrometer (ACIS) is one of two focal-plane instruments on the Chandra X-ray Observatory. During initial radiation-belt passes, the exposed ACIS suffered significant radiation damage from trapped soft protons scattering off the x-ray telescope's mirrors.
arxiv   +1 more source

Exploration of heterogeneity and recurrence signatures in hepatocellular carcinoma

open access: yesMolecular Oncology, EarlyView.
This study leveraged public datasets and integrative bioinformatic analysis to dissect malignant cell heterogeneity between relapsed and primary HCC, focusing on intercellular communication, differentiation status, metabolic activity, and transcriptomic profiles.
Wen‐Jing Wu   +15 more
wiley   +1 more source

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