Results 61 to 70 of about 2,082,361 (307)

Generation of Seed Magnetic Field around First Stars: the Biermann Battery Effect

, 2011
We investigate generation processes of magnetic fields around first stars. Since the first stars are expected to form anisotropic ionization fronts in the surrounding clumpy media, magnetic fields are generated by effects of radiation force as well as ...
Ando, Biermann, Blasi, Bromm, Clark, Fukugita, Gnedin, Greif, Hajime Susa, Kentaro Doi, Kulsrud, Machida, Machida, Maki, Maki, Nakamura, Nakano, Nakano, Navarro, Omukai, Omukai, Prada, Schleicher, Schleicher, Sethi, Sur, Tan, Vallée, Xu, Yoshida   +29 more
core   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Radiation effects on bacterial cells [PDF]

, 1968
Study reveals the physicochemical and biochemical mechanisms which alter or modify the effects of high-energy radiation on living cells. An in-depth discussion is presented emphasizing the importance of optimizing bacterial treatment with ...
Powers, E. L.
core   +1 more source

How Protostellar Outflows Help Massive Stars Form

, 2004
We consider the effects of an outflow on radiation escaping from the infalling envelope around a massive protostar. Using numerical radiative transfer calculations, we show that outflows with properties comparable to those observed around massive stars ...
Christopher F. McKee, Hoyle F., Kahn F. D., Mark R. Krumholz, Richard I. Klein, Tout C. A.   +5 more
core   +1 more source

Design considerations for combined radiation effects facilities for twelve year outer planet spacecraft voyages [PDF]

, 1972
The design considerations influencing the choice and utility of environmental simulation methods and facilities are described, insofar as they relate to the requirements imposed on outer planet spacecraft because of radiation environments to be expected.
Miller, C. G.
core   +2 more sources

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Motion and gravitational radiation of a binary system consisting of an oscillating and rotating coplanar dusty disk and a point-like object

, 2005
A binary system composed of an oscillating and rotating coplanar dusty disk and a point mass is considered. The conservative dynamics is treated on the Newtonian level.
C. Hunter, Dörte Hansen, G. Schäfer, H.M. Lee, J.M. Bardeen, K.S. Thorne, M.E. Alexander, N. Wex, S.L. Shapiro, W. Junker, W. Kley, W.H. Press   +11 more
core   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Mutational Signatures in Radiation-Induced Cancer: A Review of Experimental Animal and Human Studies

Biology
Ionizing radiation can damage DNA, leading to mutations, and is a risk factor for cancer. Based on the assumption that all radiation exposure poses a risk in linear proportion to its dose, ionizing radiation is considered a non-threshold carcinogen ...
Kazuhiro Daino, Chizuru Tsuruoka, Atsuko Ishikawa, Shizuko Kakinuma, Tatsuhiko Imaoka   +4 more
doaj   +1 more source

Germline DNA Retention in Murine and Human Rearranged T Cell Receptor Gene Coding Joints: Alternative Recombination Signal Sequences and V(D)J Recombinase Errors

Frontiers in Immunology, 2019
The genes coding for the antigenic T cell receptor (TR) subunits are assembled in thymocytes from discrete V, D, and J genes by a site-specific recombination process.
Justyna Mika, Sylwia Kabacik, Christophe Badie, Joanna Polanska, Serge M. Candéias   +4 more
doaj   +1 more source