Results 61 to 70 of about 15,483,185 (313)

Long‐Term Outcomes of Patients With Relapsed/Refractory Neuroblastoma Treated on ANBL1221: A Report From the Children's Oncology Group

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Results of COG ANBL1221 changed treatment paradigms for patients with relapsed/refractory neuroblastoma. Chemoimmunotherapy with irinotecan/temozolomide/dinutuximab is now used as both bridge therapy following suboptimal response to induction and as treatment in first relapse.
Elizabeth Sokol, Arlene Naranjo, Lulu Chen, Rajen Mody, Steven G. DuBois, Rochelle Bagatell, Navin Pinto   +6 more
wiley   +1 more source

Survival by Race and Ethnicity in Children and Adolescents/Young Adults With Relapsed/Refractory Hodgkin Lymphoma: A Pooled Analysis of Children's Oncology Group Trials

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Purpose Despite 5‐year survival rates of over 90% among children and adolescents/young adults (CAYAs) with classic Hodgkin lymphoma (cHL), 15%–20% relapse after frontline therapy. Prior analysis of frontline Children's Oncology Group (COG) clinical trials demonstrated that, despite similar rates of relapse, non‐Hispanic Black (NHB) and ...
Mallorie B. Heneghan, Lindsay A. Renfro, Yue Wu, Katia M. Crisler, Erin Marcotte, Tanya Trippett, Terzah Horton, Bradford S. Hoppe, Frank G. Keller, Chris Forlenza, Cindy Schwartz, Kara M. Kelly, Peter D. Cole, Sharon M. Castellino, Justine M. Kahn   +14 more
wiley   +1 more source

Effects of Radiation on the Tumor Microenvironment

Seminars in Radiation Oncology, 2020
A malignant tumor consists of malignant cells as well as a wide array of normal host tissues including stroma, vasculature, and immune infiltrate. The interaction between cancer and these host tissues is critical as these host tissues play a variety of ...
A. Monjazeb, K. Schalper, F. Villarroel-Espíndola, A. Nguyen, S. Shiao, K. Young   +5 more
semanticscholar   +1 more source

The Relationship Between Physical Activity and Left Ventricular Remodeling in Childhood Cancer Survivors Treated With Anthracyclines: A Cross‐Sectional Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Introduction Anthracycline‐related cardiac remodeling precedes heart failure in childhood cancer survivors. The objectives of this study were to determine the relationships between patient‐specific factors, moderate‐to‐vigorous physical activity (MVPA), and cardiac remodeling.
Hari K. Narayan, Sitong Chen, F. Lennie Wong, Nathan Young, Anna Qi, Christopher Davis, Sanjeet Hegde, Nicholas Gloude, Kasey J. Leger, Kelly D. Getz, Francisco Contijoch, Kirsten Ness, Bonnie Ky, Dennis Kuo, Sheri J. Hartman, Saro H. Armenian   +15 more
wiley   +1 more source

Mutational Signatures in Radiation-Induced Cancer: A Review of Experimental Animal and Human Studies

Biology
Ionizing radiation can damage DNA, leading to mutations, and is a risk factor for cancer. Based on the assumption that all radiation exposure poses a risk in linear proportion to its dose, ionizing radiation is considered a non-threshold carcinogen ...
Kazuhiro Daino, Chizuru Tsuruoka, Atsuko Ishikawa, Shizuko Kakinuma, Tatsuhiko Imaoka   +4 more
doaj   +1 more source

Microbiota- and Radiotherapy-Induced Gastrointestinal Side-Effects (MARS) Study: A Large Pilot Study of the Microbiome in Acute and Late-Radiation Enteropathy

Clinical Cancer Research, 2019
Purpose: Radiotherapy is important in managing pelvic cancers. However, radiation enteropathy may occur and can be dose limiting. The gut microbiota may contribute to the pathogenesis of radiation enteropathy.
M. Reis Ferreira, J. Andreyev, K. Mohammed, L. Truelove, S. Gowan, Jia V. Li, S. Gulliford, J. Marchesi, D. Dearnaley   +8 more
semanticscholar   +1 more source

Childhood Acute Lymphoblastic Leukemia Survival in Western Kenya: Reduction in Early Deaths and Treatment Abandonment

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background An earlier study on children diagnosed with acute lymphoblastic leukemia (ALL) at Moi Teaching and Referral Hospital (MTRH) in Kenya reported a low event‐free survival (EFS), excess treatment abandonment, and high induction mortality.
Gilbert Olbara, George Bogonko, Festus Njuguna, Sandra Langat, Martha Kipngetich, Dennis Njenga, Gertjan Johannes Kaspers, Terry Allen Vik   +7 more
wiley   +1 more source

Mutational profiles of spontaneous and radiation-related mammary carcinomas in a rat model of Brca1 haploinsufficiency

Scientific Reports
Female carriers of a heterozygous germline mutation in BRCA1/2 have a high risk of breast cancer. Although recent research has suggested that genomic instability via BRCA1/2 haploinsufficiency contributes to the early phase of BRCA-associated ...
Yuzuki Nakamura, Kazuhiro Daino, Atsuko Ishikawa, Shizuko Kakinuma, Yukiko Nishimura-Yano, Kento Nagata, Masaru Takabatake, Mayumi Nishimura, Tomoji Mashimo, Kazumasa Inoue, Tatsuhiko Imaoka   +10 more
doaj   +1 more source

Germline DNA Retention in Murine and Human Rearranged T Cell Receptor Gene Coding Joints: Alternative Recombination Signal Sequences and V(D)J Recombinase Errors

Frontiers in Immunology, 2019
The genes coding for the antigenic T cell receptor (TR) subunits are assembled in thymocytes from discrete V, D, and J genes by a site-specific recombination process.
Justyna Mika, Sylwia Kabacik, Christophe Badie, Joanna Polanska, Serge M. Candéias   +4 more
doaj   +1 more source

Ozone—climate interactions and effects on solar ultraviolet radiation

Photochemical and Photobiological Sciences, 2019
This report assesses the effects of stratospheric ozone depletion and anticipated ozone recovery on the intensity of ultraviolet (UV) radiation at the Earth’s surface. Interactions between changes in ozone and changes in climate, as well as their effects
A. Bais, G. Bernhard, R. McKenzie, P. Aucamp, Paul Young, M. Ilyas, P. Jöckel, M. Deushi   +7 more
semanticscholar   +1 more source