Results 61 to 70 of about 2,059,339 (331)
Assisted Inspirals of Stellar Mass Black Holes Embedded in AGN Disks: Solving the "Final AU Problem"
, 2016 We explore the evolution of stellar mass black hole binaries (BHBs) which are formed in the self-gravitating disks of active galactic nuclei (AGN). Hardening due to three-body scattering and gaseous drag are effective mechanisms that reduce the semi ...
Haiman, Zoltan +2 more
core +1 more source
The Assembly and Merging History of Supermassive Black Holes in Hierarchical Models of Galaxy Formation [PDF]
, 2002 We assess models for the assembly of supermassive black holes (SMBHs) at the center of galaxies that trace their hierarchical build-up far up in the dark halo `merger tree'.
Bower R. G. +12 more
core +2 more sources
Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source
Particle Acceleration And Emission Processes In Mrk 421
, 2013 We investigate the X-ray and $\gamma$-ray flares of Mrk 421 on 2008 June 6-15 using the synchrotron self- Compton(SSC) model with electron acceleration, in which an evident correlation between the X-ray and $\gamma$-ray bands appears, while no ...
Cao, Gang, Wang, Jiancheng
core +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
X--Ray Spectra from Neutron Stars Accreting at Low Rates [PDF]
, 1994 The spectral properties of X--ray radiation produced in a static atmosphere around a neutron star accreting at very low rates are investigated. Previous results by Alme \& Wilson (1973) are extended to the range $10^{-7}\leq L/L_{Edd}\leq 10^{-3}$ to ...
Treves, Aldo +3 more
core +3 more sources
Targeting p38α in cancer: challenges, opportunities, and emerging strategies
Molecular Oncology, EarlyView.p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley +1 more source
Integrated Circuit Design for Radiation-Hardened Charge-Sensitive Amplifier Survived up to 2 Mrad
Sensors, 2020 According to the continuous development of metal-oxide semiconductor (MOS) fabrication technology, transistors have naturally become more radiation-tolerant through steadily decreasing gate-oxide thickness, increasing the tunneling probability between ...
Changyeop Lee +4 more
doaj +1 more source
Radiation hardening of components and systems for nuclear rocket vehicle applications [PDF]
, 1972 The results of the analysis of the S-2 and S-4B components, although incomplete, indicate that many Saturn 5 components and subsystems, e.g., pumps, valves, etc., can be radiation hardened to meet NRV requirements by material substitution and minor ...
Cheever, P. R., Greenhow, W. A.
core +1 more source