Results 51 to 60 of about 15,979 (310)

Direct Observation of Cu Clusters and Dislocation Loops by Cs-Corrected STEM in Fe-0.6wt%Cu Alloy Irradiated in BR2

Metals, 2022
The neutron irradiation of Fe-based fusion and fission reactor materials leads to an increase in ductile-to-brittle transition temperature with a decrease in upper shelf energy. It is well known that Cu content has a strong influence on the embrittlement
Hideo Watanabe, Tomonari Tanaka, Takuya Turu, Yasuhiro Kamada   +3 more
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Hardening electronic devices against very high total dose radiation environments [PDF]

, 1972
The possibilities and limitations of hardening silicon semiconductor devices to the high neutron and gamma radiation levels and greater than 10 to the eighth power rads required for the NERVA nuclear engine development are discussed. A comparison is made
Shedd, W., Roosild, S., Dolan, R., Buchanan, B.   +3 more
core   +2 more sources

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

The effect of Laves phase on heavy-ion radiation response of Nb-containing FeCrAl alloy for accident-tolerant fuel cladding

Fundamental Research, 2022
As a promising candidate material for the accident tolerant fuel cladding in light water reactors, the Nb-containing FeCrAl alloy has shown outstanding out-of-pile service performance due to the Laves phase precipitation.
Hang Xu, Shuyao Si, Yipeng Li, Xiangbing Liu, Wenqing Li, Changzhong Jiang, Shijun Zhao, Hui Wang, Xiangheng Xiao   +8 more
doaj   +1 more source

Radiation Hardening

AbstractTo cope with the threats of a harsh environment containing energetic particles, scientists and engineers have been developing mitigation strategies and hardening techniques to improve the resilience of electronic systems. Considering that the radiation environment and the operation conditions are known, as it will be shown in this chapter ...
Ygor Quadros de Aguiar, Frédéric Wrobel, Jean-Luc Autran, Rubén García Alía   +3 more
openaire   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Radiation Hardening by Design of Asynchronous Logic for Hostile Environments [PDF]

, 2020
A wide range of emerging applications is driving the development of wireless sensor node technology towards a monolithic system-on-a-chip implementation.
Barnhart, DJ, Sweeting, MN, Stevens, KS, Vladimirova, T   +3 more
core   +3 more sources

Radiation hardening of optical fibers and fiber sensors for space applications: recent advances [PDF]

, 2017
In these ICSO proceedings, we review recent advances from our group concerning the radiation hardening of optical fiber and fiber-based sensors for space applications and compare their benefits to state-of-the-art results.
Ladaci, A., Girard, S., Ouerdane, Y., L. Mescia, Mescia, L., Cadier, B., Pinsard, E., Y. Ouerdane, T. Robin, A. Ladaci, B. Cadier, A. Boukenter, Robin, T., Boukenter, A., S. Girard, A. Laurent, Laurent, A., E. Pinsard   +17 more
core   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source