Results 51 to 60 of about 1,463,362 (312)
Molecular Oncology, EarlyView.In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico +5 more
wiley +1 more source
Radiation hardening of optical fibers and fiber sensors for space applications: recent advances [PDF]
, 2017 In these ICSO proceedings, we review recent advances from our group concerning the radiation hardening of optical fiber and fiber-based sensors for space applications and compare their benefits to state-of-the-art results.
Ladaci, A. +17 more
core +1 more source
Research progress on irradiation effect of InP-based high electron mobility transistors
He jishuIndium phosphide (InP)-based high electron mobility transistors (HEMTs) have been widely adopted in space communication systems such as satellites, manned spaceflight, and deep space exploration due to their high frequency and gain, and low noise ...
FANG Renfeng +7 more
doaj +1 more source
Enhanced Radiation Tolerance of a Remote Interface Unit Using Commercial-off-the-Shelf Components for Space Applications [PDF]
فصلنامه علوم و فناوری فضاییThe radiation hardness of satellite subsystems, particularly their susceptibility to total ionizing dose (TID), presents a significant challenge in space mission design. This study introduces an innovative approach to enhancing the radiation tolerance of
Reza Omidi, Azam Eidi
doaj +1 more source
Molecular Oncology, EarlyView.The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim +17 more
wiley +1 more source
Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy
Molecular Oncology, EarlyView.We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley +1 more source
Type I interferons modulate autophagy to shape gemcitabine response in pancreatic cancer cells
FEBS Open Bio, EarlyView.Type I interferons differentially modulate autophagy and the response of pancreatic cancer cells to gemcitabine. IFNα2b stimulates autophagic flux and protects cells from gemcitabine‐induced cell death, contributing to chemoresistance. In contrast, IFNβ1a inhibits autophagosome formation and enhances gemcitabine‐induced cell death, resulting in ...
Lucy E. Bonilla +10 more
wiley +1 more source
A Radiation Hardened Field Oxide [PDF]
IEEE Transactions on Nuclear Science, 1977 This paper describes the results of a radiation-tolerant field oxide development compatible with both MOS and bipolar technologies. Data is presented which illustrates that nonguardbanded devices utilizing conventional field oxide structures cannot be expected to survive an ionizing radiation dose above approximately 5 × 104 rads (Si) due to inversion ...
J. R. Adams, W. R. Dawes, T. J. Sanders
openaire +1 more source
FEBS Open Bio, EarlyView.Functional screening identified PcSyn14890, a cyanobacteria‐specific protein that enhances growth and stress resistance in E. coli and Synechocystis PCC6803. Although we expected it to function as a molecular chaperone, it was unable to protect against thermal aggregation of GAPDH.
Akiyo Yamada +7 more
wiley +1 more source
Ion irradiation effects on FeCrAl-ODS ferritic steel
Nuclear Materials and Energy, 2018 The correlation between microstructure and mechanical property of ion irradiated 12Cr-6Al ODS ferritic steel was studied. Ion irradiation experiments were performed using 10.5 MeV Fe ions up to the nominal displacement damage of 20 dpa with the damage ...
K. Kondo +6 more
doaj +1 more source