Results 61 to 70 of about 72,269 (350)

Radiation Hardening of CMOS Microelectronics [PDF]

, 2000
A unique methodology, silicon transfer to arbitrary substrates, has been developed under this program and is being investigated as a technique for significantly increasing the radiation insensitivity of limited quantities of conventional silicon microelectronic circuits.
McCarthy, A., Sigmon, T. W.
openaire   +2 more sources

Lattice strain measurements using synchrotron diffraction to calibrate a micromechanical modeling in a ferrite–cementite steel [PDF]

, 2013
In situ tensile tests were performed at room temperature on a ferrite–cementite steel specifically designed for this study. The evolution of the average stress in ferrite during loading was analyzed by X-ray diffraction.Lattice strain measurements were ...
BERBENNI, Stéphane, BERVEILLER, Sophie, BOUAZIZ, Olivier, OUAHAB, Razane, PESCI, Raphaël, TAUPIN, Vincent   +5 more
core   +6 more sources

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Numerical Models for the Diffuse Ionized Gas in Galaxies. II. Three-dimensional radiative transfer in inhomogeneous interstellar structures as a tool for analyzing the diffuse ionized gas

, 2018
Aims: We systematically explore a plausible subset of the parameter space involving effective temperatures and metallicities of the ionizing stellar sources, the effects of the hardening of their radiation by surrounding leaky HII regions with different ...
Hoffmann, T. L., Pauldrach, A. W. A., Weber, J. A.   +2 more
core   +1 more source

Rates and Characteristics of Intermediate Mass Ratio Inspirals Detectable by Advanced LIGO [PDF]

, 2008
Gravitational waves (GWs) from the inspiral of a neutron star (NS) or stellar-mass black hole (BH) into an intermediate-mass black hole (IMBH) with mass between ~50 and ~350 solar masses may be detectable by the planned advanced generation of ground ...
Duncan A. Brown, Finn L. S., Fitchett M. J., Fitchett M. J., Freitag M., Freitag M., Heggie D. C., Hopman C., Ilya Mandel, Jonathan R. Gair, M. Coleman Miller, Redmount I. H., Taniguchi Y., Trenti M.   +13 more
core   +2 more sources

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Ion irradiation effects on FeCrAl-ODS ferritic steel

Nuclear Materials and Energy, 2018
The correlation between microstructure and mechanical property of ion irradiated 12Cr-6Al ODS ferritic steel was studied. Ion irradiation experiments were performed using 10.5 MeV Fe ions up to the nominal displacement damage of 20 dpa with the damage ...
K. Kondo, S. Aoki, S. Yamashita, S. Ukai, K. Sakamoto, M. Hirai, A. Kimura   +6 more
doaj   +1 more source

Integrated Circuit Design for Radiation-Hardened Charge-Sensitive Amplifier Survived up to 2 Mrad

Sensors, 2020
According to the continuous development of metal-oxide semiconductor (MOS) fabrication technology, transistors have naturally become more radiation-tolerant through steadily decreasing gate-oxide thickness, increasing the tunneling probability between ...
Changyeop Lee, Gyuseong Cho, Troy Unruh, Seop Hur, Inyong Kwon   +4 more
doaj   +1 more source

Radiation Hardening

AbstractTo cope with the threats of a harsh environment containing energetic particles, scientists and engineers have been developing mitigation strategies and hardening techniques to improve the resilience of electronic systems. Considering that the radiation environment and the operation conditions are known, as it will be shown in this chapter ...
Ygor Quadros de Aguiar, Frédéric Wrobel, Jean-Luc Autran, Rubén García Alía   +3 more
openaire   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source