Results 51 to 60 of about 547,234 (309)

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Focal Spot, Spring 2001 [PDF]

, 2001
https://digitalcommons.wustl.edu/focal_spot_archives/1087/thumbnail ...

core   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Focal Spot, Fall/Winter 1988 [PDF]

, 1988
https://digitalcommons.wustl.edu/focal_spot_archives/1050/thumbnail ...

core   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Carbon Ion Radiotherapy in the Management of Hepatocellular Carcinoma

Journal of Hepatocellular Carcinoma, 2021
Belal Abousaida,1,* Danushka Seneviratne,1,* Bradford S Hoppe,1 Stephen J Ko,1 Aroumougame Asaithamby,2 Francis A Cucinotta,3 Jessica M Kirwan,4 Kabir Mody,5 Beau Toskich,6 Jonathan B Ashman,7 Christopher L Hallemeier,8 Sunil Krishnan1 ...
Abousaida B, Seneviratne D, Hoppe BS, Ko SJ, Asaithamby A, Cucinotta FA, Kirwan JM, Mody K, Toskich B, Ashman JB, Hallemeier CL, Krishnan S   +11 more
doaj  

Image guidance in radiation therapy for better cure of cancer

Molecular Oncology, 2020
The key goal and main challenge of radiation therapy is the elimination of tumors without any concurring damages of the surrounding healthy tissues and organs.
Vincent Grégoire, Matthias Guckenberger, Karin Haustermans, Jan J. W. Lagendijk, Cynthia Ménard, Richard Pötter, Ben J. Slotman, Kari Tanderup, Daniela Thorwarth, Marcel vanHerk, Daniel Zips   +10 more
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Dose delivery reproducibility for PBS proton treatment of breast cancer patients with and without mask immobilization

Radiation Oncology, 2023
Background Setup reproducibility of the tissue in the proton beam path is critical in maintaining the planned clinical target volume (CTV) dose coverage and sparing the organs at risk (OAR).
Yixiu Kang, Martin Bues, Michele Y. Halyard, Lisa A. McGee, Tamara Z. Vern-Gross, William W. Wong, Sameer R. Keole, Carlos Vargas, Sarah E. James, Safia K. Ahmed, James P. Archuleta, Ana K. Ridgway, Pedro R. Lara, Mirek Fatyga   +13 more
doaj   +1 more source

Focal Spot, Fall/Winter 1994 [PDF]

, 1994
https://digitalcommons.wustl.edu/focal_spot_archives/1068/thumbnail ...

core   +1 more source