Results 51 to 60 of about 972,051 (351)

Hospital Quality Factors Influencing the Mobility of Patients for Radical Prostate Cancer Radiation Therapy: A National Population-Based Study. [PDF]

, 2017
PURPOSE: To investigate whether patients requiring radiation treatment are prepared to travel to alternative more distant centers in response to hospital choice policies, and the factors that influence this mobility. METHODS AND MATERIALS: We present the
Aggarwal, Ajay, Charman, Susan C, Lewis, Daniel, Mason, Malcolm, Payne, Heather, Sujenthiran, Arunan, Sullivan, Richard, van der Meulen, Jan   +7 more
core   +4 more sources

Exploration of heterogeneity and recurrence signatures in hepatocellular carcinoma

Molecular Oncology, EarlyView.
This study leveraged public datasets and integrative bioinformatic analysis to dissect malignant cell heterogeneity between relapsed and primary HCC, focusing on intercellular communication, differentiation status, metabolic activity, and transcriptomic profiles.
Wen‐Jing Wu, Jianchao Wang, Fuqing Chen, Xuefeng Wang, Bin Lan, Ruyi Fu, Hong Wen, Fangfang Chen, Wei Hong, Tian‐Yu Tang, Ying He, Gang Chen, Jianyin Zhou, Hai‐Long Piao, Di Chen, Shu‐Yong Lin   +15 more
wiley   +1 more source

RRx-001, A novel dinitroazetidine radiosensitizer. [PDF]

, 2016
The 'holy grail' in radiation oncology is to improve the outcome of radiation therapy (RT) with a radiosensitizer-a systemic chemical/biochemical agent that additively or synergistically sensitizes tumor cells to radiation in the absence of significant ...
Bednarski, Mark, Cabrales, Pedro, Knox, Susan, Ning, Shoucheng, Oronsky, Arnold, Oronsky, Bryan, Peehl, Donna, Scicinski, Jan   +7 more
core   +1 more source

Multidimensional OMICs reveal ARID1A orchestrated control of DNA damage, splicing, and cell cycle in normal‐like and malignant urothelial cells

Molecular Oncology, EarlyView.
Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser, Florian Krumbach, Eyleen Corrales, Geoffroy Andrieux, Christian Preisinger, Franziska Liss, Alexandra Golzmann, Melanie Boerries, Kerstin Becker, Ruth Knüchel, Stefan Garczyk, Bernhard Lüscher   +11 more
wiley   +1 more source

Intravenous contrast media in radiation therapy planning computed tomography scans – Current practice in Ireland

Technical Innovations & Patient Support in Radiation Oncology, 2019
Introduction: While Computerised Tomography (CT) remains the gold standard in radiation therapy (RT) planning, inferior soft tissue definition remains a challenge.
Shane Minogue, Charles Gillham, Maeve Kearney, Laura Mullaney   +3 more
doaj  

Clinical results of proton beam therapy for twenty older patients with esophageal cancer

Radiology and Oncology, 2015
Background. In an aging society, increasing number of older patients are diagnosed with esophageal cancer. The purpose of this study was to assess the clinical efficacy and safety of proton beam therapy for older patients with esophageal cancer.
Ono Takashi, Nakamura Tatsuya, Azami Yusuke, Yamaguchi Hisashi, Hayashi Yuichiro, Suzuki Motohisa, Hatayama Yoshiomi, Tsukiyama Iwao, Hareyama Masato, Kikuchi Yasuhiro, Nemoto Kenji   +10 more
doaj   +1 more source

Fractionation in radiation therapy

International Journal of Radiation Oncology*Biology*Physics, 1987
Variations in schedule from the usual 200 cGy daily, 5 days a week, for six or seven weeks, will be reviewed with both the radiobiological basis and clinical results so far. Hyperfractionated schedules (e.g., 1.15 Gy b.i.d. for 7 weeks) have given lo-15% better local control than the conventional 7-week schedule, with no extra late effects, both in ...
openaire   +2 more sources

Aberrant expression of nuclear prothymosin α contributes to epithelial‐mesenchymal transition in lung cancer

Molecular Oncology, EarlyView.
Nuclear prothymosin α inhibits epithelial‐mesenchymal transition (EMT) in lung cancer by increasing Smad7 acetylation and competing with Smad2 for binding to SNAI1, TWIST1, and ZEB1 promoters. In early‐stage cancer, ProT suppresses TGF‐β‐induced EMT, while its loss in the nucleus in late‐stage cancer leads to enhanced EMT and poor prognosis.
Liyun Chen, Chung‐Teng Wang, Jia‐Ming Chang, Ai‐Li Shiau, Gia‐Shing Shieh, Yau‐Lin Tseng, Yi‐Ting Yen, Tang‐Hsiu Huang, Li‐Hsin Cheng, Yu‐Chih Wu, Chao‐Liang Wu, Bing‐Hua Su, Pensee Wu   +12 more
wiley   +1 more source

Overview on topical 5-ALA photodynamic therapy use for non melanoma skin cancers [PDF]

, 2014
Ultraviolet radiation (UV) contributes to a variety of skin diseases including inflammation, degenerative aging, and cancer. Historically, humans have been exposed to UV radiation mainly through occupational exposure; recreational UV exposure, however ...
Bianchini, Daniela, Calvieri, Stefano, Cantisani, Carmen, Cantoresi, Franca, Faina, Valentina, Fazia, Gilda, Frascani, Federica, Paolino, Giovanni   +7 more
core   +3 more sources

Determination of ADP/ATP translocase isoform ratios in malignancy and cellular senescence

Molecular Oncology, EarlyView.
The individual functions of three isoforms exchanging ADP and ATP (ADP/ATP translocases; ANTs) on the mitochondrial membrane remain unclear. We developed a method for quantitatively differentiating highly similar human ANT1, ANT2, and ANT3 using parallel reaction monitoring. This method allowed us to assess changes in translocase levels during cellular
Zuzana Liblova, Dominika Maurencova, Barbora Salovska, Marek Kratky, Tomas Mracek, Zuzana Korandova, Alena Pecinova, Pavla Vasicova, David Rysanek, Ladislav Andera, Ivo Fabrik, Rudolf Kupcik, Pavel Kashmel, Pinky Sultana, Vojtech Tambor, Jiri Bartek, Josef Novak, Marie Vajrychova, Zdenek Hodny   +18 more
wiley   +1 more source