Results 51 to 60 of about 33,535 (269)

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Constraints on power law and exponential models in f(Q) gravity

Physics Letters B
In this paper, we observationally test the f(Q) gravity model at both background and perturbation levels using Pantheon+, Hubble measurements, and Redshift Space Distortion Data.
Dalale Mhamdi, Farida Bargach, Safae Dahmani, Amine Bouali, Taoufik Ouali   +4 more
doaj   +1 more source

ComFC mediates transport and handling of single-stranded DNA during natural transformation

Nature Communications, 2022
The ComFC protein is essential for natural transformation, a process that plays a major role in the spread of antibiotic resistance genes. Here the authors show that ComFC is a membrane-associated protein that participates in the transport of DNA through
Prashant P. Damke, Louisa Celma, Sumedha M. Kondekar, Anne Marie Di Guilmi, Stéphanie Marsin, Jordane Dépagne, Xavier Veaute, Pierre Legrand, Hélène Walbott, Julien Vercruyssen, Raphaël Guérois, Sophie Quevillon-Cheruel, J. Pablo Radicella   +12 more
doaj   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

Mitotic dynamics of the nuclear lamina behind the scenes of chromosome separation

Communications Biology
The regulation of mitosis is essential for genome inheritance and stability. In mammals, many cellular ultrastructures, including the nuclear envelope, undergo significant morphological changes to facilitate chromosome separation.
Julien Picotto, Pascale Bertrand, Gaëlle Pennarun   +2 more
doaj   +1 more source

The discrete ordinate method for angular flux calculations in slab geometry

Heliyon, 2019
In many deterministic methods, concerning the resolution of the neutron transport equation, a more global and practical representation of the angular flux is needed to provide us with useful and complete information on the neutron population in a reactor
M. Lahdour, T. El Bardouni, M. Mohammed, S. El Ouahdani   +3 more
doaj   +1 more source

Interferon beta drives therapy resistance in a patient‐derived model of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant, Tise Suzuki, Kiera McGivney, V. S. S. Abhinav Ayyadevara, Sharon Asariah, Jay Deng, Ethan Nyein, Jacqueline Coats, Gary Yu, Yevgeniya J. Ioffe, Christian Hurtz, Juli J. Unternaehrer   +11 more
wiley   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

A comparative analysis of the NaI detector response function using GAMOS and FLUKA Monte Carlo simulations

Nuclear Analysis
This work aims to study the response function of a 2″×2″ NaI(Tl) scintillation detector using Monte Carlo simulations. A precise mathematical model of the NaI(Tl) scintillator was developed using both FLUKA and GAMOS Monte Carlo simulation software.
A. Arectout, H. Boukhal, E. Chakir, M. Jarmouni, M. Assalmi, T. El Ghalbzouri, O.E. Belhaj, Mohamed Drissi El-Bouzaidi, A. Nouayti, I. Zidouh, H. El Yaakoubi   +10 more
doaj   +1 more source

Positron-based attenuation correction for Positron Emission Tomography data using MCNP6 code

Journal of Radiation Research and Applied Sciences, 2016
This paper presents the Monte Carlo simulation of the attenuation correction for Positron Emission Tomography (PET) data using MCNP6 code. Two attenuation correction maps have been generated, one for correcting the attenuation effect in a homogeneous ...
M. Saeed, T. El Khoukhi, Y. Boulaich, E. Chakir, M. Maged, H. Boukhal, T. El Bardouni   +6 more
doaj   +1 more source