Results 91 to 100 of about 286,073 (277)

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Dynamics of femtosecond lasers and induced plasma in non-Kerr nonlinear transparent materials: Competing effects of electron–hole radiative recombinations and single-electron diffusions

AIP Advances
Modern laser micromachining utilizes ultrashort optical fields, such as femtosecond lasers, to perform high-precision processings on solid materials, including cutting, drilling, ablation, polishing, and scripturing.
I. Ngek Ndifon, Alain M. Dikandé
doaj   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Radiative Processes in Microquasars

, 2002
6 pages; figures in color; Proceedings of the 4th Microquasar Workshop, eds. Ph. Durouchoux, Y. Fuchs and J.
Poutanen, Juri, Zdziarski, Andrzej A.
openaire   +2 more sources

Ionized Envelopes Around Protoplanets and the Role of Radiative Feedback in Gas Accretion

The Astrophysical Journal
Planetary growth within protoplanetary disks involves the accreting of material from their surroundings, yet the underlying mechanisms and physical conditions of the accreting gas remain debated.
Matías Montesinos, Juan Garrido-Deutelmoser, Jorge Cuadra, Mario Sucerquia, Nicolás Cuello, Matthias R. Schreiber, María Paula Ronco, Octavio M. Guilera   +7 more
doaj   +1 more source

Anticancer sensitivities and biological characteristics of HCT116 cells resistant to the selective poly(ADP‐ribose) glycohydrolase inhibitor

FEBS Open Bio, EarlyView.
We analyzed alterations of PAR metabolism‐related proteins in PARG inhibitor‐resistant HCT116RPDD cells. Although PARG levels remained unchanged, HCT116RPDD cells exhibited reduced PARP1 and ARH3 expression and elevated PAR levels. Interestingly, HCT116RPDD cells exhibited slightly elevated intracellular NAD+/NADH and ATP levels. Our findings suggest a
Kaede Tsuda, Yoko Ogino, Akira Sato
wiley   +1 more source

Blue Luminescence from N-doped Graphene

The Astrophysical Journal
Blue luminescence (BL) has been observed in various astrophysical environments, such as the inner region of the Red Rectangle Nebula. It has been previously linked to small polycyclic aromatic hydrocarbons.
Shu-Yu Lin, Sheng-Lung Chou, Tzu-Ping Huang, Meng-Yeh Lin, Hui-Fen Chen, Peter J. Sarre, Chien-Ming Tseng, Yu-Jong Wu   +7 more
doaj   +1 more source

First measurement of proton's charge form factor at very low Q2 with initial state radiation

Physics Letters B, 2017
We report on a new experimental method based on initial-state radiation (ISR) in e–p scattering, which exploits the radiative tail of the elastic peak to study the properties of electromagnetic processes and to extract the proton charge form factor (GEp)
M. Mihovilovič, A.B. Weber, P. Achenbach, T. Beranek, J. Beričič, J.C. Bernauer, R. Böhm, D. Bosnar, M. Cardinali, L. Correa, L. Debenjak, A. Denig, M.O. Distler, A. Esser, M.I. Ferretti Bondy, H. Fonvieille, J.M. Friedrich, I. Friščić, K. Griffioen, M. Hoek, S. Kegel, Y. Kohl, H. Merkel, D.G. Middleton, U. Müller, L. Nungesser, J. Pochodzalla, M. Rohrbeck, S. Sánchez Majos, B.S. Schlimme, M. Schoth, F. Schulz, C. Sfienti, S. Širca, S. Štajner, M. Thiel, A. Tyukin, M. Vanderhaeghen, M. Weinriefer   +38 more
doaj   +1 more source

Tuning the collective decay of two entangled emitters by means of a nearby surface

, 2017
We consider the radiative properties of a system of two identical correlated atoms interacting with the electromagnetic field in its vacuum state in the presence of a generic dielectric environment.
Barcellona, P., Buhmann, S. Y., Palacino, R., Passante, R., Rizzuto, L.   +4 more
core   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source